朴煕万 (Park Hyi-Man) - マイポータル

基本情報

所属: 株式会社 PRISM BioLab 取締役研究開発部部長

学位: 農学(名古屋大学)
農学博士(名古屋大学)

研究者番号: 90743625
J-GLOBAL ID: 201601008920333537
researchmap会員ID: 7000016519

研究キーワード

研究分野

経歴

2021年9月 - 現在

株式会社 PRISM BioLab 取締役研究開発部部長
2018年4月 - 2021年8月

名古屋大学, 環境医学研究所ラクオリア創薬産学協同研究センター薬効解析部門, 特任教授
2011年10月 - 2021年8月

ラクオリア創薬株式会社創薬研究部門生物研究部部長
2018年4月 - 2019年3月

名古屋大学, 環境医学研究所ラクオリア創薬産学協同研究センター, 副センター長
2014年4月 - 2018年3月

名古屋大学, 環境医学研究所薬効解析部門, 特任准教授
2008年9月 - 2011年9月

Novartis Institutes for BioMedical Research Inc. / Cardiovascular & Metabolism Disease / Research Investigator
2000年10月 - 2008年8月

ノバルティスファーマ株式会社筑波研究所研究本部創薬生物グループラボヘッド
2000年4月 - 2000年9月

University of Minnesota, Medical school, Biochemistry, Postdoctoral fellow
1998年4月 - 2000年4月

日本学術振興会海外特別研究員ミネソタ大学医学部生化学

学歴

1995年4月 - 1998年3月

名古屋大学, 農学系研究科, 動物栄養情報学
1993年4月 - 1995年3月

名古屋大学, 農学系研究科, 動物栄養情報学
1989年4月 - 1993年3月

名古屋大学, 農学部

論文

Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models

Ken Yamada, Julian Levell, Taeyong Yoon, Darcy Kohls, David Yowe, Dean F. Rigel, Hidetomo Imase, Jun Yuan, Kayo Yasoshima, Keith DiPetrillo …

JOURNAL OF MEDICINAL CHEMISTRY 60(16) 7099-7107 2017年8月査読有り
Discovery and Characterization of Allosteric WNK Kinase Inhibitors

Ken Yamada, Ji-Hu Zhang, Xiaoling Xie, Juergen Reinhardt, Amy Qiongshu Xie, Daniel LaSala, Darcy Kohls, David Yowe, Debra Burdick, Hajime Yoshisue …

ACS CHEMICAL BIOLOGY 11(12) 3338-3346 2016年12月
Small-molecule WNK inhibition regulates cardiovascular and renal function

Ken Yamada, Hyi-Man Park, Dean F. Rigel, Keith DiPetrillo, Erin J. Whalen, Anthony Anisowicz, Michael Beil, James Berstler, Cara Emily Brocklehurst, Debra A. Burdick …

NATURE CHEMICAL BIOLOGY 12(11) 896-+ 2016年11月
Interferon regulatory factors (IRFs) repress transcription of the chicken ovalbumin gene

Dawne C. Dougherty, Hyi-Man Park, Michel M. Sanders

GENE 439(1-2) 63-70 2009年6月
Regulation of expression of the mouse adiponectin gene by the C/EBP family via a novel enhancer region

Chie Koshfishi, Hyi-Man Park, Hidefumi Uchiyama, Yasuo Tanaka

GENE 424(1-2) 141-146 2008年11月
Tumor growth inhibition by synthetic and expressed siRNA targeting focal adhesion kinase

Kae Tsutsumi, Tatsuhiko Kasaoka, Hyi-Man Park, Hiroko Nishiyama, Motowo Nakajima, Toshiyuki Honda

INTERNATIONAL JOURNAL OF ONCOLOGY 33(1) 215-224 2008年7月
An oviduct-specific and enhancer-like element resides at about-3000 in the chicken ovalbumin gene

Hyi-Man Park, Michel M. Sanders, Takayuki Suzuki, Tatsuo Muramatsu

BIOCHIMIE 88(12) 1909-1914 2006年12月
Human alkaline phosphatase expression and secretion into chicken eggs after in vivo gene electroporation in the oviduct of laying hens

H Takami, H Watanabe, Y Ohmori, HM Park, T Muramatsu

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 292(1) 88-93 2002年3月
Elevated gastrin secretion by in vivo gene electroporation in skeletal muscle

A Yasui, K Oka, H Usunomiya, K Kakudo, T Suzuki, T Yoshida, HM Park, K Fukazawa, T Muramatsu

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 8(5) 489-494 2001年11月
An integrase facilitates long-lasting foreign gene expression in vivo in mouse spermatogenic cells

S Ryoki, HM Park, Y Ohmori, A Shoji-Tanaka, T Muramatsu

JOURNAL OF BIOSCIENCE AND BIOENGINEERING 91(4) 363-367 2001年4月
In vivo gene electroporation confers nutritionally-regulated foreign gene expression in the liver

T Muramatsu, N Ito, N Tamaoki, H Oda, HM Park

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 7(1) 61-66 2001年1月
In vivo gene electroporation in skeletal muscle with special reference to the duration of gene expression

T Muramatsu, S Arakawa, K Fukazawa, Y Fujiwara, T Yoshida, R Sasaki, S Masuda, HM Park

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 7(1) 37-42 2001年1月
In vivo gene electroporation confers strong transient expression of foreign genes in the chicken testis

K Sugihara, HM Park, T Muramatsu

POULTRY SCIENCE 79(8) 1116-1119 2000年8月
COUP-TF plays a dual role in the regulation of the ovalbumin gene

HM Park, SE Haecker, SG Hagen, MM Sanders

BIOCHEMISTRY 39(29) 8537-8545 2000年7月
Foreign gene expression by in vivo gene electroporation in the quail testis

K Sugihara, HM Park, T Muramatsu

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY 125(1) 47-52 2000年1月
Gene gun-mediated human erythropoietin gene expression in primary cultured oviduct cells from laying hens

H Ochiai, HM Park, R Sasaki, J Okumura, T Muramatsu

ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES 12(1) 9-14 1999年2月
In vivo manipulation of foreign gene expression by steroid administration in the oviduct of laying hens

H. M. Park, T. Muramatsu

Journal of Endocrinology 163(2) 173-179 1999年
Gene gun-mediated in vivo analysis of tissue-specific repression of gene transcription driven by the chicken ovalbumin promoter in the liver and oviduct of laying hens

T Muramatsu, T Imai, HM Park, H Watanabe, A Nakamura, J Okumura

MOLECULAR AND CELLULAR BIOCHEMISTRY 185(1-2) 27-32 1998年8月
Basics and applications of gene transfer in animal cells and tissues for production and therapeutics

Muramatsu T, Nakamura A, Park HM

Journal of Mammalian Ova Research 15(1) 1-16-16 1998年4月
Synthesis of human erythropoietin in vivo in the oviduct of laying hens by localized in vivo gene transfer using electroporation

H Ochiai, HM Park, A Nakamura, R Sasaki, J Okumura, T Muramatsu

POULTRY SCIENCE 77(2) 299-302 1998年2月

もっとみる

MISC

Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models

Ken Yamada, Julian Levell, Taeyong Yoon, Darcy Kohls, David Yowe, Dean F. Rigel, Hidetomo Imase, Jun Yuan, Kayo Yasoshima, Keith DiPetrillo …

JOURNAL OF MEDICINAL CHEMISTRY 60(16) 7099-7107 2017年8月査読有り
Discovery and Characterization of Allosteric WNK Kinase Inhibitors

Ken Yamada, Ji-Hu Zhang, Xiaoling Xie, Juergen Reinhardt, Amy Qiongshu Xie, Daniel LaSala, Darcy Kohls, David Yowe, Debra Burdick, Hajime Yoshisue …

ACS CHEMICAL BIOLOGY 11(12) 3338-3346 2016年12月
Small-molecule WNK inhibition regulates cardiovascular and renal function

Ken Yamada, Hyi-Man Park, Dean F. Rigel, Keith DiPetrillo, Erin J. Whalen, Anthony Anisowicz, Michael Beil, James Berstler, Cara Emily Brocklehurst, Debra A. Burdick …

NATURE CHEMICAL BIOLOGY 12(11) 896-+ 2016年11月
Interferon regulatory factors (IRFs) repress transcription of the chicken ovalbumin gene

Dawne C. Dougherty, Hyi-Man Park, Michel M. Sanders

GENE 439(1-2) 63-70 2009年6月
Regulation of expression of the mouse adiponectin gene by the C/EBP family via a novel enhancer region

Chie Koshfishi, Hyi-Man Park, Hidefumi Uchiyama, Yasuo Tanaka

GENE 424(1-2) 141-146 2008年11月
Tumor growth inhibition by synthetic and expressed siRNA targeting focal adhesion kinase

Kae Tsutsumi, Tatsuhiko Kasaoka, Hyi-Man Park, Hiroko Nishiyama, Motowo Nakajima, Toshiyuki Honda

INTERNATIONAL JOURNAL OF ONCOLOGY 33(1) 215-224 2008年7月
An oviduct-specific and enhancer-like element resides at about-3000 in the chicken ovalbumin gene

Hyi-Man Park, Michel M. Sanders, Takayuki Suzuki, Tatsuo Muramatsu

BIOCHIMIE 88(12) 1909-1914 2006年12月
Human alkaline phosphatase expression and secretion into chicken eggs after in vivo gene electroporation in the oviduct of laying hens

H Takami, H Watanabe, Y Ohmori, HM Park, T Muramatsu

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 292(1) 88-93 2002年3月
Elevated gastrin secretion by in vivo gene electroporation in skeletal muscle

A Yasui, K Oka, H Usunomiya, K Kakudo, T Suzuki, T Yoshida, HM Park, K Fukazawa, T Muramatsu

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 8(5) 489-494 2001年11月
An integrase facilitates long-lasting foreign gene expression in vivo in mouse spermatogenic cells

S Ryoki, HM Park, Y Ohmori, A Shoji-Tanaka, T Muramatsu

JOURNAL OF BIOSCIENCE AND BIOENGINEERING 91(4) 363-367 2001年4月
In vivo gene electroporation confers nutritionally-regulated foreign gene expression in the liver

T Muramatsu, N Ito, N Tamaoki, H Oda, HM Park

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 7(1) 61-66 2001年1月
In vivo gene electroporation in skeletal muscle with special reference to the duration of gene expression

T Muramatsu, S Arakawa, K Fukazawa, Y Fujiwara, T Yoshida, R Sasaki, S Masuda, HM Park

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 7(1) 37-42 2001年1月
In vivo gene electroporation confers strong transient expression of foreign genes in the chicken testis

K Sugihara, HM Park, T Muramatsu

POULTRY SCIENCE 79(8) 1116-1119 2000年8月
COUP-TF plays a dual role in the regulation of the ovalbumin gene

HM Park, SE Haecker, SG Hagen, MM Sanders

BIOCHEMISTRY 39(29) 8537-8545 2000年7月
Foreign gene expression by in vivo gene electroporation in the quail testis

K Sugihara, HM Park, T Muramatsu

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY 125(1) 47-52 2000年1月
Gene gun-mediated human erythropoietin gene expression in primary cultured oviduct cells from laying hens

H Ochiai, HM Park, R Sasaki, J Okumura, T Muramatsu

ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES 12(1) 9-14 1999年2月
In vivo manipulation of foreign gene expression by steroid administration in the oviduct of laying hens

H. M. Park, T. Muramatsu

Journal of Endocrinology 163(2) 173-179 1999年
Gene gun-mediated in vivo analysis of tissue-specific repression of gene transcription driven by the chicken ovalbumin promoter in the liver and oviduct of laying hens

T Muramatsu, T Imai, HM Park, H Watanabe, A Nakamura, J Okumura

MOLECULAR AND CELLULAR BIOCHEMISTRY 185(1-2) 27-32 1998年8月
Basics and applications of gene transfer in animal cells and tissues for production and therapeutics

Muramatsu T, Nakamura A, Park HM

Journal of Mammalian Ova Research 15(1) 1-16-16 1998年4月
Synthesis of human erythropoietin in vivo in the oviduct of laying hens by localized in vivo gene transfer using electroporation

H Ochiai, HM Park, A Nakamura, R Sasaki, J Okumura, T Muramatsu

POULTRY SCIENCE 77(2) 299-302 1998年2月

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