MISC

2015年

Cell shape and cell lineage conversion

Journal of Poultry Science
  • Yukiko Nakaya
  • ,
  • Guojun Sheng

52
1
開始ページ
1
終了ページ
6
記述言語
英語
掲載種別
書評論文,書評,文献紹介等
DOI
10.2141/jpsa.0140088
出版者・発行元
Japan Poultry Science Association

The organization of animal cells in vivo can be categorized as being either epithelial or mesenchymal. Interconversions between these two states, epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET), often represent key events in animal development and pathogenesis. The molecular and cellular mechanisms by which cell-cell and cell-substrate interactions are governed during EMT/MET have been examined extensively. Recent studies have also shown that EMT/MET is implicated in the acquisition of stemness in cancer cells and is accompanied by changes in epigenetic modifications. Ongoing progresses in regenerative medicine suggest that morphological and physical changes can facilitate somatic cell reprogramming and help achieve stemness. In this review, we will describe the principles of EMT/MET, their roles in cancer and normal animal development, and their relationship to stemness. We will conclude by emphasizing that studying cell shape changes in development is important for mechanistic understanding of how EMT/MET contributes to cell lineage conversion in cancer research and therapeutic medicine.

リンク情報
DOI
https://doi.org/10.2141/jpsa.0140088
ID情報
  • DOI : 10.2141/jpsa.0140088
  • ISSN : 1349-0486
  • ISSN : 1346-7395
  • SCOPUS ID : 84921869963

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