Isomonodromic deformation of linear differential equations on ℙ1 with regular and irregular singular points is considered from the view point of twistor theory. We give explicit form of isomonodromic deformation using the maximal abelian subgroup H of G = GLN+1(ℂ) which appeared in the theory of general hypergeometric functions on a Grassmannian manifold. This formulation enables us to obtain a group of symmetry for the nonlinear system which is an Weyl group analogue NG (H)/H. © 2013 The authors.