桑田岳夫 (Takeo Kuwata) - マイポータル

基本情報

所属: 熊本大学ヒトレトロウイルス学共同研究センター特任講師

学位: 博士（医学）(京都大学)

J-GLOBAL ID: 201601013196849953
researchmap会員ID: 7000016971

研究キーワード

研究分野

経歴

2017年7月 - 現在

熊本大学, エイズ学研究センター, 特任講師
2011年7月 - 2017年6月

熊本大学, エイズ学研究センター, 助教
2008年2月 - 2011年6月

熊本大学, 大学院先導機構, 特任助教
2011年

Assistant Professor,Center for AIDS Research,Kumamoto University
2003年4月 - 2008年1月

米国NIH, NIAID, LMM, Visiting fellow
2002年4月 - 2003年3月

京都大学, ウイルス研究所, 助手

学歴

1994年4月 - 1998年3月

京都大学大学院, 医学研究科, 博士課程
1992年4月 - 1994年3月

京都大学大学院, 人間・環境研究科, 修士課程
1987年4月 - 1991年3月

早稲田大学, 教育学部, 理学科生物専修

論文

Synergistic inhibition of cell-to-cell HIV-1 infection by combinations of single chain variable fragments and fusion inhibitors.

Alam MM, Kuwata T, Tanaka K, Alam M, Takahama S, Shimura K, Matsuoka M, Fukuda N, Morioka H, Tamamura H …

Biochemistry and biophysics reports 20 100687-100687 2019年12月査読有り
The role of conventional antibodies targeting the CD4 binding site and CD4-induced epitopes in the control of HIV-1 CRF01_AE viruses

Win Thida, Takeo Kuwata, Yosuke Maeda, Tetsu Yamashiro, Giang Van Tran, Kinh Van Nguyen, Masafumi Takiguchi, Hiroyuki Gatanaga, Kazuki Tanaka, Shuzo Matsushita

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 508(1) 46-51 2019年1月査読有り
Total HIV-1 DNA dynamics and influencing factors in long-term ART-treated Japanese adults: a retrospective longitudinal analysis

Stanoeva KR, Konig A, Fukuda A, Kawanami Y, Kuwata T, Satou Y, Matsushita S

Journal of acquired immune deficiency syndromes 1(78) 239-247 2018年6月1日査読有り
Unique binding modes for the broad neutralizing activity of single-chain variable fragments (scFv) targeting CD4-induced epitopes

Kazuki Tanaka, Takeo Kuwata, Muntasir Alam, Gilad Kaplan, Shokichi Takahama, Kristel Paola Ramirez Valdez, Anna Roitburd-Berman, Jonathan M. Gershoni, Shuzo Matsushita

RETROVIROLOGY 14(1) 44 2017年9月査読有り
Cross-Neutralization Activity of Single-Chain Variable Fragment (scFv) Derived from Anti-V3 Monoclonal Antibodies Mediated by Post-Attachment Binding

Yasuhiro Maruta, Takeo Kuwata, Kazuki Tanaka, Muntasir Alam, Kristel Paola Ramirez Valdez, Yoshika Egami, Yoshiaki Suwa, Hiroshi Morioka, Shuzo Matsushita

JAPANESE JOURNAL OF INFECTIOUS DISEASES 69(5) 395-404 2016年9月査読有り
Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors

Muntasir Alam, Takeo Kuwata, Kazuya Shimura, Masaru Yokoyama, Kristel Paola Ramirez Valdez, Kazuki Tanaka, Yasuhiro Maruta, Shinya Oishi, Nobutaka Fujii, Hironori Sato …

RETROVIROLOGY 13(1) 70 2016年9月査読有り
Incompatible Natures of the HIV-1 Envelope in Resistance to the CCR5 Antagonist Cenicriviroc and to Neutralizing Antibodies

Takeo Kuwata, Ikumi Enomoto, Masanori Baba, Shuzo Matsushita

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 60(1) 437-450 2016年1月査読有り
Immunoglobulin V-H gene diversity and somatic hypermutation during SIV infection of rhesus macaques

Kejun Guo, Kalani Halemano, Kimberly Schmitt, Miki Katuwal, Yaqiong Wang, Michael S. Harper, Karl J. Heilman, Takeo Kuwata, Edward B. Stephens, Mario L. Santiago

IMMUNOGENETICS 67(7) 355-370 2015年7月査読有り
Complementary and synergistic activities of anti-V3, CD4bs and CD4i antibodies derived from a single individual can cover a wide range of HIV-1 strains

Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, Shuzo Matsushita

VIROLOGY 475 187-203 2015年1月査読有り
Conformational Epitope Consisting of the V3 and V4 Loops as a Target for Potent and Broad Neutralization of Simian Immunodeficiency Viruses

Takeo Kuwata, Kaori Takaki, Kazuhisa Yoshimura, Ikumi Enomoto, Fan Wu, Ilnour Ourmanov, Vanessa M. Hirsch, Masaru Yokoyama, Hironori Sato, Shuzo Matsushita

JOURNAL OF VIROLOGY 87(10) 5424-5436 2013年5月査読有り
Increased infectivity in human cells and resistance to antibody-mediated neutralization by truncation of the SIV gp41 cytoplasmic tail

Takeo Kuwata, Kaori Takaki, Ikumi Enomoto, Kazuhisa Yoshimura, Shuzo Matsushita

FRONTIERS IN MICROBIOLOGY 4 117 2013年5月査読有り
Sequential Evolution and Escape from Neutralization of Simian Immunodeficiency Virus SIVsmE660 Clones in Rhesus Macaques

Fan Wu, Ilnour Ourmanov, Takeo Kuwata, Robert Goeken, Charles R. Brown, Alicia Buckler-White, Ranjini Iyengar, Ronald Plishka, Scott T. Aoki, Vanessa M. Hirsch

JOURNAL OF VIROLOGY 86(16) 8835-8847 2012年8月査読有り
Isolation of Potent Neutralizing Monoclonal Antibodies from an SIV-Infected Rhesus Macaque by Phage Display

Takeo Kuwata, Yuko Katsumata, Kaori Takaki, Tomoyuki Miura, Tatsuhiko Igarashi

AIDS RESEARCH AND HUMAN RETROVIRUSES 27(5) 487-500 2011年5月査読有り
Improved Survival in Rhesus Macaques Immunized with Modified Vaccinia Virus Ankara Recombinants Expressing Simian Immunodeficiency Virus Envelope Correlates with Reduction in Memory CD4(+) T-Cell Loss and Higher Titers of Neutralizing Antibody

Ilnour Ourmanov, Takeo Kuwata, Robert Goeken, Simoy Goldstein, Ranjani Iyengar, Alicia Buckler-White, Bernard Lafont, Vanessa M. Hirsch

JOURNAL OF VIROLOGY 83(11) 5388-5400 2009年6月査読有り
Association of Progressive CD4(+) T Cell Decline in SIV Infection with the Induction of Autoreactive Antibodies

Takeo Kuwata, Yoshiaki Nishimura, Sonya Whitted, Ilnour Ourmanov, Charles R. Brown, Que Dang, Alicia Buckler-White, Ranjini Iyengar, Jason M. Brenchley, Vanessa M. Hirsch

PLOS PATHOGENS 5(4) 2009年4月査読有り
Rapid progressor-specific variant clone of simian immunodeficiency virus replicates efficiently in vivo only in the absence of immune reponses

Takeo Kuwata, Russell Byrum, Sonya Whitted, Robert Goeken, Alicia Buckler-White, Ronald Plishka, Ranjini Iyengar, Vanessa M. Hirsch

JOURNAL OF VIROLOGY 81(17) 8891-8904 2007年9月査読有り
Contribution of monocytes to viral replication in macaques during acute infection with simian immunodeficiency virus

Takeo Kuwata, Makoto Kodama, Akihiko Sato, Hajime Suzuki, Yasuyuki Miyazaki, Tomoyuki Miura, Masanori Hayami

AIDS RESEARCH AND HUMAN RETROVIRUSES 23(3) 372-380 2007年3月査読有り
DNA vaccination of macaques by a full-genome SHIV plasmid that has an IL-2 gene and produces non-infectious virus particles

R Horiuchi, W Akahata, T Kuwata, Y Enose, E Ido, H Suzuki, A Miyake, N Saito, K Buki, T Goto …

VACCINE 24(17) 3677-3685 2006年4月査読有り
Infectious molecular clones from a simian immunodeficiency virus-infected rapid-progressor (RP) macaque: Evidence of differential selection of RP-specific envelope mutations in vitro an in vivo

T Kuwata, H Dehghani, CR Brown, R Plishka, A Buckler-White, T Igarashi, J Mattapallil, M Roederer, VM Hirsch

JOURNAL OF VIROLOGY 80(3) 1463-1475 2006年2月査読有り
DNA vaccination of macaques by a full-genome simian/human immunodeficiency virus type 1 plasmid chimera that produces non-infectious virus particles

W Akahata, E Ido, H Akiyama, H Uesaka, Y Enose, R Horiuchi, T Kuwata, T Goto, H Takahashi, M Hayami

JOURNAL OF GENERAL VIROLOGY 84(Pt 8) 2237-2244 2003年8月査読有り

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