Tsukamoto, Tetsuo

J-GLOBAL         Last updated: Sep 7, 2019 at 10:04
Tsukamoto, Tetsuo
Kindai University
Department of Immunology, Faculty of Medicine
Job title
Assistant Professor
MBBS/M.D.(University of Tokyo), Ph.D.(University of Tokyo)
Research funding number
Twitter ID


Tetsuo Tsukamoto is a researcher looking for methods to better understand HIV's interaction with the host from the point of view of the immune system design. He has published studies on HIV vaccine development using rhesus macaques, HIV-specific CD8+ T-cell responses, anti-HIV gene therapy using humanized mice, and hematopoietic stem/progenitor cell dynamics in HIV infection.

Research Areas

  • Basic medicine / Immunology / Acquired immunodeficiency syndrome
  • Basic medicine / Virology / Human immunodeficiency virus

Academic & Professional Experience

Apr 2017
Assistant Professor, Department of Immunology, Faculty of Medicine, Kindai University
Jan 2016
Mar 2017
Researcher, Center for AIDS Research, Kumamoto University
Jul 2013
Dec 2015
Senior Research Officer, Kirby Institute for infection and immunity in society, University of New South Wales
Feb 2011
Jan 2013
Researcher, Division of Immuno-Virology, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)
Apr 2008
Mar 2010
Researcher, International Research Center for Infectious Diseases, The Institute of Medical Science, the University of Tokyo


Apr 2004
Mar 2008
Pathology, Immunology and Microbiology, Graduate School of Medicine, The University of Tokyo
Apr 1998
Mar 2004
School of Medicine, Faculty of Medicine, The University of Tokyo

Committee Memberships

Sep 2019
Frontiers in Microbiology  Peer reviewer
Jul 2019
Brain Sciences  Peer reviewer
Jul 2019
Virology Journal  Peer reviewer
Jul 2019
Frontiers in Immunology  Peer reviewer
Jun 2019
Diagnostics  Peer reviewer
May 2019
Frontiers in Cellular and Infection Microbiology  Guest associated editor
Mar 2019
Pharmaceutics  Peer reviewer
Jun 2018
AIDS  Peer reviewer

Awards & Honors

Jun 2019
Medical Society of Kindai University Award, Medical Society of Kindai University
Winner: Tsukamoto T
Oct 2009
AIDS Vaccine 2009 International Scholarship, Global HIV Vaccine Enterprise
Winner: Tsukamoto T
Jun 2003
The 6th Summer Retrovirus Conference (SRC 2003) Best Presentation Award, Japan Retrovirus Study Group
Winner: Tsukamoto T

Published Papers

Tsukamoto T, Tsuji-Kawahara S, Miyazawa M
Bio Clinica   34(6) 629-635   Jun 2019   [Refereed][Invited]
Tsukamoto T
Pharmaceutics   11(3) 114   Mar 2019   [Refereed][Invited]
Although current antiretroviral drug therapy can suppress human immunodeficiency
virus (HIV) replication, a lifelong prescription is necessary to avoid viral rebound. The problem of
persistent and ineradicable viral reservoirs in HIV-infected peop...
Tsukamoto T
Frontiers in Immunology   10 81   Jan 2019   [Refereed]
HIV-1 causes the loss of CD4+ T cells via depletion or impairment of their production. The latter involves infection of thymocytes, but the involvement of hematopoietic CD34+ cells remains unclear even though HIV-positive patients frequently manif...
Tsukamoto T (corresponding author), Yamamoto H, Matano T
mSphere   4(1) e00381-18   Jan 2019   [Refereed]
Cytotoxic-T-lymphocyte (CTL) responses are important to control the replication of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV). Accumulating evidence suggests that the ability of a few immunodominant T-cell populatio...
Tsukamoto T (corresponding author), Kariya R, Marks K, Hattori S, Ahlenstiel C, Symonds G, Okada S, Kelleher AD
AIDS   32(18) 2857-2858   Nov 2018   [Refereed]
Tsukamoto T
AIDS   32(13) 1737-1747   Aug 2018   [Refereed]
Objectives: Hematological abnormalities that include changes in bone marrow, such as in anemia and pancytopenia, are common among human immunodeficiency virus (HIV)-infected patients, particularly in the advanced stage of disease. Such abnormaliti...
Tsukamoto T (corresponding author), Okada S
Journal of Virological Methods   248 234-237   Oct 2017   [Refereed]
Human immunodeficiency virus (HIV) causes damage, directly or indirectly, to the whole hematopoietic system, including CD34+ hematopoietic stem/progenitor cells (HSPCs). CXCR4-tropic strains of HIV-1 may affect the function of CD34+CXCR4+ progenit...
Tsukamoto T (corresponding author), Yamamoto H, Okada S, Matano T
Medical Hypotheses   94 81-85   Sep 2016   [Refereed]
Although antiretroviral therapy has made human immunodeficiency virus (HIV) infection a controllable disease, it is still unclear how viral replication persists in untreated patients and causes CD4+ T-cell depletion leading to acquired immunodefic...
Tsukamoto T
Cahier multiculturel de la Maison du Japon   6 3-11   Oct 2013   [Refereed][Invited]
Most viral infections are controlled by host immune response, although there are some exceptions. For example, HIV infects a component of the immune system called T lymphocytes, and the immune system fails to control the HIV infection. This lead...
Nomura T, Yamamoto H, Shiino T, Takahashi N, Nakane T, Iwamoto N, Ishii H, Tsukamoto T, Kawada M, Matsuoka S, Takeda A, Terahara K, Tsunetsugu-Yokota Y, Iwata-Yoshikawa N, Hasegawa H, Sata T, Naruse T. K, Kimura A, Matano T.
J Virol   86(12) 6481-90   Jun 2012   [Refereed]


Antigen presentation by pulmonary macrophages drives the establishment of lung-resident CD8 T cell memory (conference abstract)
Takamura S, Dunbar P, Cartwright E, Wein A, Tsukamoto T, Li Z, Kumar N, Uddbaeck I, Hawyard S, Ueha S, Kohlmeier J
Annual Meeting Proceedings of The Japanese Society for Immunology   47 Page2-A-WS14-19-O/P   Dec 2018   [Refereed]
Takahashi N, Iwamoto N, Moriya C, Tsukamoto T, Matano T
Journal of Medical Primatology   39(4) 298-298   2010   [Refereed]

Books etc

Clinical Mucosal Immunology
Tsukamoto T (Part:Contributor, AIDS)
Synergy International Inc.   Dec 2010   ISBN:9784916166340

Conference Activities & Talks

Takamura S, Dunbar P, Cartwright E, Wein A, Tsukamoto T, Li Z, Kumar N, Uddbaeck I, Hawyard S, Ueha S, Kohlmeier J
The 47th Annual Meeting of the Japanese Society for Immunology   10 Dec 2018   The Japanese Society for Immunology
Tsukamoto T
The 32th Annual Meeting of the Japanese Society for AIDS Research   2 Dec 2018   The Japanese Society for AIDS Research
Tsukamoto T, Miyazawa M
The 66th Annual Meeting of the Japanese Society for Virology   28 Oct 2018   The Japanese Society for Virology
[Background] Understanding the biology of cancer stem cells having long-term self-renewal capacity is critical for finding better treatment strategies. There has been marked progress in characterizing human acute myeloid leukemia (AML) stem cells....
Tsukamoto T, Miyazawa M
The 30th International Workshop on Retroviral Pathogenesis   8 Oct 2018   
The pathogenesis of Friend virus (FV)-induced erythroleukemia has widely been interpreted as a multistage leukemogenesis in which (1) the spleen focus-forming virus (SFFV) envelope (gp55) activates the receptor tyrosine kinase Sf-Stk and cause the...
Tsukamoto T
The 16th Awaji International Forum on Infection and Immunity   5 Sep 2017   
Hematological abnormalities are common among HIV-infected patients. Of those, bone marrow changes such as anemia and pancytopenia can be observed in advanced HIV disease. However, experimental evidence for those manifestations in animal immunodefi...
Tsukamoto T, Okada S
2nd Kumamoto IRCMS International Symposium and 17th Kumamoto AIDS Seminar   31 Oct 2016   
A persistent viral replication model using the OP9-DL1 coculture system with in vitro HIV-infected CD34+ cells
Tsukamoto T, Okada S
The 63th Annual Meeting of the Japanese Society for Virology   22 Nov 2015   The Japanese Society for Virology
[Background] CD34+ hematopoietic stem/progenitor cells have recently been found to be a possible HIV-1 reservoir. It was demonstrated that a subset of CD34+ cells express CD4 and CXCR4 and can be infected with CXCR4-tropic HIV-1 strains. It was al...
A parallel information-processing hypothesis could explain the efficacy of broad cytotoxic T-cell response against HIV-infected cells with low antigen expression levels
Tsukamoto T
16th Kumamoto AIDS Seminar   7 Oct 2015   
In HIV infection, broad cytotoxic T-lymphocyte (CTL) response recognizing diverse T-cell epitopes is considered effective in controlling the viral replication because it exerts strong immune pressure even upon CTL escape variant viruses. However, ...
Imagining virus-specific CD4+ T-cell dynamics through a macaque AIDS model [Invited]
Tsukamoto T
International young investigator seminar in retroviruses and host responses   10 Jul 2014   

Teaching Experience



Tsukamoto T   Software   2003 - 2005
Based on the old version of the thumb-shift input method Omelet written for Emacs/Tamago version 3, I wrote a new version of Omelet that works with Tamago version 4.
Tsukamoto T   Software   Jul 2000
SKK-JISYO.zipcode … Postal codes except those included in the below file
SKK-JISYO.office.zipcode … Postal codes for offices

Research Grants & Projects

The Japan Society for the Promotion of Science: Grant-in-Aid for Scientific Research (C)
Project Year: Apr 2019 - Mar 2022    Investigator(s): Tsukamoto T
Analysis of the mechanistic relationships between erythropoiesis and the maintenance of Friend virus-induced erythroleukemia stem cells
Kindai University: Collaborative Research Grant
Project Year: Apr 2019 - Mar 2022    Investigator(s): Tsukamoto T
Study on the interactions between HIV-1 and bone marrow CD34+ hematopoietic stem/progenitor cells
The Imai Memorial Trust for AIDS Research: Research Grant
Project Year: Jul 2019 - Jun 2020    Investigator(s): Tsukamoto T
The Ichiro Kanehara Foundation: The 32th Scholarship Grant for Research in Basic Medical Sciences and Medical Care
Project Year: Oct 2017 - Sep 2018    Investigator(s): Tsukamoto T
Astellas Foundation for Research on Metabolic Disorders: Kumamoto Eathquake Emergency Research Grant
Project Year: Jun 2016 - Mar 2017    Investigator(s): Tsukamoto T
Primate Research Institute, Kyoto University: Joint Research Program
Project Year: Oct 2015 - Mar 2017    Investigator(s): Tsukamoto T, Okada S
In vitro and in vivo analysis of the impact of human CD34+ hematopoietic stem/progenitor cells on HIV pathogenesis and latency
Center for AIDS Research, Kumamoto University: AIDS International Collaborative Research Grant
Project Year: Jan 2015 - Dec 2016    Investigator(s): Okada S

Social Contribution

[Contribution, Others]  Wikimedia foundation  Oct 2010 - Today
Contribution to Wikipedia entries including Cytokine, Symphony No. 5 (Mahler), and so forth.
Meeting with students from Hyundai Chungun High School, South Korea
[Interviewee]  Hyundai Chungun High School, South Korea  Global Learning Scholarship program  (Kindai University Faculty of Medicine)  5 May 2019
Two students from Hyundai Chungun High School, South Korea visited the campus of Kindai University Faculty of Medicine with the support of the high school's Global Learning Scholarship (GLS) program. They discussed with Dr. Tetsuo Tsukamoto on pot...
[Organizing Member]  SKK Openlab  (Japan)  Oct 1999 - Sep 2010
SKK was designed by Dr. Masahiko Sato (Professor Emeritus, Kyoto University) and created in 1987. After participating in the volunteer group, I worked as a developer (1999-2005) and a maintainer (2006-2010).