OSATO MOTOMI

J-GLOBAL         Last updated: May 20, 2019 at 22:35
 
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Name
OSATO MOTOMI
Affiliation
Kumamoto University
Section
International Research Center for Medical Sciences

Profile

Motomi Osato received his M.D. from Oita Medical University and Ph.D. from Kumamoto University (thesis supervisors, Kiyoshi Takatsuki and Norio Asou). After postdoctoral research training in Yoshiaki Ito’s laboratory at Kyoto University and Institute of Molecular and Cell Biology, Singapore, he established his own laboratory at Cancer Science Institute of Singapore, National University of Singapore (NUS). He is currently Associate Professor at NUS and Professor at Kumamoto University. He has been studying the molecular mechanism of leukemogenesis by RUNX and related genes, employing cell biological approaches, in vivo mouse and zebrafish systems and analysis of human leukemia samples. His best known research accomplishment is the detection of point mutations in the RUNX1/AML1 gene in leukemia patients.

Research Areas

 
 

Academic & Professional Experience

 
Apr 2015
 - 
Today
Professor, International Research Center for Medical Sciences, Kumamoto University
 
Oct 2008
 - 
Today
Associate Professor, Cancer Science Institute, National University of Singapore
 
Apr 2002
 - 
Sep 2008
Assistant Professor, Institute of Molecular and Cell Biology (Singapore)
 
Apr 1997
 - 
Mar 2002
Research Fellow, Institute for Virus Research, Kyoto University
 
Apr 1990
 - 
Mar 1993
Clinical Fellow, Kumamoto University Hospital
 

Education

 
Apr 1993
 - 
Mar 1997
Graduate School of Medicine, Kumamoto Univeristy
 
Apr 1984
 - 
Mar 1990
Oita Medical University
 

Committee Memberships

 
2012
 - 
Today
Gene  Associate Editor
 

Published Papers

 
Yokomizo T, Watanabe N, Umemoto T, Matsuo J, Harai R, Kihara Y, Nakamura E, Tada N, Sato T, Takaku T, Shimono A, Takizawa H, Nakagata N, Mori S, Kurokawa M, Tenen DG, Osato M, Suda T, Komatsu N
The Journal of experimental medicine      May 2019   [Refereed]
Tsukada M, Ota Y, Wilkinson AC, Becker HJ, Osato M, Nakauchi H, Yamazaki S
Stem cell reports   9(4) 1024-1033   Oct 2017   [Refereed]
Kubota S, Tokunaga K, Umezu T, Yokomizo-Nakano T, Sun Y, Oshima M, Tan KT, Yang H, Kanai A, Iwanaga E, Asou N, Maeda T, Nakagata N, Iwama A, Ohyashiki K, Osato M, Sashida G
Nature communications   10(1) 1653   Apr 2019   [Refereed]
Marsman J, Thomas A, Osato M, O'Sullivan JM, Horsfield JA
Scientific reports   7(1) 13347   Oct 2017   [Refereed]
Matsumura T, Nakamura-Ishizu A, Takaoka K, Maki H, Muddineni SSNA, Wang CQ, Suzushima H, Kawakita M, Asou N, Matsuoka M, Kurokawa M, Osato M, Suda T
British journal of haematology      Mar 2019   [Refereed]
Shen H, Shin EM, Lee S, Mathavan S, Koh H, Osato M, Choi H, Tergaonkar V, Korzh V
Scientific reports   7(1) 8094   Aug 2017   [Refereed]
Kuan JW, Su AT, Leong CF, Osato M, Sashida G
International journal of hematology   109(1) 130   Jan 2019   [Refereed]
Zhou J, Chan ZL, Bi C, Lu X, Chong PS, Chooi JY, Cheong LL, Liu SC, Ching YQ, Zhou Y, Osato M, Tan TZ, Ng CH, Ng SB, Wang S, Zeng Q, Chng WJ
Molecular cancer research : MCR   15(3) 294-303   Mar 2017   [Refereed]
Kuan JW, Su AT, Leong CF, Osato M, Sashida G
International journal of hematology   108(5) 465-484   Nov 2018   [Refereed]
Ng IK, Lee J, Ng C, Kosmo B, Chiu L, Seah E, Mok MMH, Tan K, Osato M, Chng WJ, Yan B, Tan LK
Biomarker research   6 16   2018   [Refereed]
Wang CQ, Mok MM, Yokomizo T, Tergaonkar V, Osato M
Advances in experimental medicine and biology   962 117-138   2017   [Refereed]
Manachai N, Saito Y, Nakahata S, Bahirvani AG, Osato M, Morishita K
Biochemical and biophysical research communications   482(4) 994-1000   Jan 2017   [Refereed]
Matsuo J, Kimura S, Yamamura A, Koh CP, Hossain MZ, Heng DL, Kohu K, Voon DC, Hiai H, Unno M, So JB, Zhu F, Srivastava S, Teh M, Yeoh KG, Osato M, Ito Y
Gastroenterology   152(1) 218-231.e14   Jan 2017   [Refereed]
Jayapal SR, Ang HY, Wang CQ, Bisteau X, Caldez MJ, Xuan GX, Yu W, Tergaonkar V, Osato M, Lim B, Kaldis P
Cell cycle (Georgetown, Tex.)   15(22) 3070-3081   Nov 2016   [Refereed]
D. W L Chin, M. Sakurai, G. S S Nah, L. Du, B. Jacob, T. Yokomizo, T. Yokomizo, T. Matsumura, T. Suda, T. Suda, G. Huang, X. Y. Fu, X. Y. Fu, Y. Ito, Y. Ito, H. Nakajima, M. Osato, M. Osato, M. Osato, M. Osato
Blood Cancer Journal   6    Jan 2016
© 2016, Nature Publishing Group. All rights reserved.RUNX1/AML1 is among the most commonly mutated genes in human leukemia. Haploinsufficiency of RUNX1 causes familial platelet disorder with predisposition to myeloid malignancies (FPD/MM). However...
Iizuka K, Yokomizo T, Watanabe N, Tanaka Y, Osato M, Takaku T, Komatsu N
PloS one   11(5) e0156427   2016   [Refereed]
Wong WF, Kohu K, Nagashima T, Funayama R, Matsumoto M, Movahed E, Tan GM, Yeow TC, Looi CY, Kurokawa M, Osato M, Igarashi K, Nakayama K, Satake M
Molecular immunology   68(2 Pt A) 223-233   Dec 2015   [Refereed]
D. W L Chin, N. Watanabe-Okochi, C. Q. Wang, C. Q. Wang, V. Tergaonkar, M. Osato, M. Osato, M. Osato, M. Osato
Leukemia   29 1970-1980   Oct 2015
© 2015 Macmillan Publishers Limited.RUNX1 and CBFB are among the most frequently mutated genes in human leukemias. Genetic alterations such as chromosomal translocations, copy number variations and point mutations have been widely reported to resu...
Lim RS, Osato M, Kai T
Current protocols in stem cell biology   34 2E.3.1-15   Aug 2015   [Refereed]
Lim JH, Ravikumar S, Wang YM, Thamboo TP, Ong L, Chen J, Goh JG, Tay SH, Chengchen L, Win MS, Leong W, Lau T, Foo R, Mirza H, Tan KS, Sethi S, Khoo AL, Chng WJ, Osato M, Netea MG, Wang Y, Chai LY
The Journal of infectious diseases   212(4) 635-644   Aug 2015   [Refereed]

Misc

 
造血器腫瘍における分子病態の理解と臨床応用への展望 T細胞性急性リンパ性白血病におけるコア転写調節回路とオンコジェニックエンハンサーの解明
三田 貴臣, Liau Wei-Siang, Mansour Marc R., Kwiatkowski Nicholas, Zhang Tinghu, Lawton Lee N., Tan Shi Hao, Wang Chelsia Q., 大里 元美, Gray Nathanael S., Young Richard A., Look A. Thomas
日本癌学会総会記事   74回 SST5-2   Oct 2015
胃体部幹細胞特異的エンハンサーを用いた胃がん研究(Stomach corpus epithelial stem cell specific enhance for the study of gastric carcinogenesis)
松尾 純一, 木村 俊一, 河府 和義, 大里 元美, 伊藤 嘉明
日本癌学会総会記事   72回 231-231   Oct 2013
南部由希子, 林達成, JANG Kyoung‐Jin, 青木耕史, 真野浩人, 中野圭子, 大里元美, 高橋克, 伊藤克彦, 手良向聡, 小守壽文, 藤田潤, 伊藤嘉明, 清水章, 菅井学
日本分子生物学会年会プログラム・要旨集(Web)   35th 4P-0456 (WEB ONLY)   2012
横溝智雅, 望月奈穂美, 黒羽高志, 依馬正次, 大里元美, 岡田斉, 小川峰太郎, 西川伸一, 伊藤嘉明
日本分子生物学会年会プログラム・講演要旨集   26th 626   Nov 2003
松野直史, 大里元美, 福島俊洋, 泉二登志子, 楠本修也, 唐渡雅行, 鈴木律朗, 直江知樹, 西井一浩
臨床血液   44(8) 652   Aug 2003

Conference Activities & Talks

 
造血幹細胞特異的遺伝子操作を可能とするRunx1 enhancer-CreERT2トランスジェニックマウス(Runx1 enhancer-CreERT2 transgenic mice for hematopoietic stem cells-specific gene targeting, imaging and transgenesis)
大里 元美
日本癌学会総会記事   Sep 2014   
世界で活躍するがん研究者の視点 Runxファミリー遺伝子と発がん機構(Challenging cancer research from international frontier Runx family genes and tumorigenesis)
大里 元美
日本癌学会総会記事   Aug 2012   
Runx1/AML1不全は造血幹細胞/前駆細胞において発癌性Rasの誘導する細胞老化、アポトーシスおよび分化を抑制する(Runx1/AML1 insufficiency attenuates oncogenic RAS-induced senescence, apoptosis and differentiation in hematopoietic stem/progenitor cells)
大里 元美, 元田 玲奈, 山下 南海子, 柳田 匡俊, 依田 広, 谷内 一郎, 伊藤 嘉明
日本癌学会総会記事   Sep 2006   
RUNX1/AML1の増量投与は骨髄性白血病の発生を促進する DS-AMKL(ダウン症関連急性巨核芽球性白血病)の意味(An increased dose of RUNX1/AML1 promotes the development of myeloid leukemia: implications for DS-AMKL)
大里 元美, 柳田 匡俊, 山下 南海子, 岩崎 正幸, 中村 卓郎, 横溝 智雅, 高橋 智, 山本 雅之, 重定 勝哉, 伊藤 嘉明
日本癌学会総会記事   Sep 2004   
大里 元美, Cottles Gregory, 呉 楓, 横溝 智雅, 柳田 匡俊, 重定 勝哉, 伊藤 嘉明
日本癌学会総会記事   26 Sep 2001