論文

国際誌
2021年7月10日

Awakening of the zygotic genome by pioneer transcription factors.

Current opinion in structural biology
  • Wataru Kobayashi
  • ,
  • Kikuë Tachibana

71
開始ページ
94
終了ページ
100
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.sbi.2021.05.013

After fertilization, the genome of the totipotent embryo is transcriptionally inactive and then initiates bursts of transcription termed zygotic genome activation (ZGA). Despite the fundamental importance of initiating an embryonic transcription program for the start of life, the essential regulators and molecular mechanisms triggering ZGA in most organisms are poorly understood. One mechanism centers on pioneer factors that function in cellular reprogramming and differentiation. Recent studies revealed that not only a single but multiple pioneer factors bind cooperatively to the genome to open chromatin, resulting in changes in epigenetic modifications and triggering ZGA. Here, we review recent insights into the functions of pioneer factors during ZGA and discuss the potential relevance to three-dimensional chromatin organization during embryonic development.

リンク情報
DOI
https://doi.org/10.1016/j.sbi.2021.05.013
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34256217
ID情報
  • DOI : 10.1016/j.sbi.2021.05.013
  • PubMed ID : 34256217

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