Wataru Kobayashi

Profile Information

Affiliation: Max Planck Institute of Biochemistry (MPIB)

Degree: 博士(理学)(早稲田大学)

Researcher number: 20778063
J-GLOBAL ID: 201601016475186696
researchmap Member ID: 7000017473

Research Interests

Research Areas

Research History

Oct, 2021 - Present

Max Planck Institute of Biochemistry (MPIB)
Apr, 2021 - Mar, 2022

早石修記念海外留学助成
Apr, 2019 - Aug, 2021

Institute of Molecular Biotechnology
Apr, 2019 - Mar, 2021

日本学術振興会海外特別研究員
Apr, 2018 - Mar, 2019

Faculty of Science and Engineering, Waseda University
Apr, 2017 - Mar, 2018

Faculty of Science and Engineering, Waseda University
Apr, 2016 - Mar, 2017

Faculty of Science and Engineering, Waseda University
Apr, 2013 - Mar, 2016

Waseda University

Education

Apr, 2013 - Mar, 2016

Waseda University
Apr, 2011 - Mar, 2013

Waseda University
Apr, 2007 - Mar, 2011

School of Advanced Science and Engineering, Waseda University

Awards

Jul, 2023

MPIB Junior Scientists’ Publication Award (JSPA)
Dec, 2016

第39回日本分子生物学会年会優秀ポスター賞, 日本分子生物学会

小林航
Dec, 2015

若手優秀発表賞, 第38回日本分子生物学会年会・第88回日本生化学会大会合同大会

小林航

Papers

Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism by DNA minor groove anchor competition.

Wataru Kobayashi, Anna H Sappler, Daniel Bollschweiler, Maximilian Kümmecke, Jérôme Basquin, Eda Nur Arslantas, Siwat Ruangroengkulrith, Renate Hornberger, Karl Duderstadt, Kikuë Tachibana

Nature structural & molecular biology, Feb 26, 2024 Peer-reviewedLead author
Zygotic genome activation by the totipotency pioneer factor Nr5a2

Johanna Gassler*, Wataru Kobayashi*, Imre Gáspár*, Siwat Ruangroengkulrith*, Adarsh Mohanan, Laura Gómez Hernández, Pavel Kravchenko, Maximilian Kümmecke, Aleksandar Lalic, Nikita Rifel …

Science, Nov 24, 2022 Peer-reviewedLead author
Zygotic genome activation by the totipotency pioneer factor Nr5a2

Johanna Gassler*, Wataru Kobayashi*, Imre Gáspár*, Siwat Ruangroengkulrith*, Maximilian Kümmecke, Pavel Kravchenko, Maciej Zaczek, Antoine Vallot, Laura Gomez Hernandez, Laura Cuenca Rico …

bioRxiv, May, 2022 Lead author
Distinctive nuclear zone for RAD51-mediated homologous recombinational DNA repair

Yasunori Horikoshi, Hiroki Shima, Jiying Sun, Wataru Kobayashi, Volker J. Schmid, Hiroshi Ochiai, Lin Shi, Atsuhiko Fukuto, Yasuha Kinugasa, Hitoshi Kurumizaka …

Nov 30, 2021
Awakening of the zygotic genome by pioneer transcription factors.

Wataru Kobayashi, Kikuë Tachibana

Current opinion in structural biology, 71 94-100, Jul 10, 2021
Structural basis of nucleosomal histone H4 lysine 20 methylation by SET8 methyltransferase.

Cheng-Han Ho, Yoshimasa Takizawa, Wataru Kobayashi, Yasuhiro Arimura, Hiroshi Kimura, Hitoshi Kurumizaka

Life science alliance, 4(4), Apr, 2021 Peer-reviewed
Cryo-EM Structures of Centromeric Tri-nucleosomes Containing a Central CENP-A Nucleosome.

Yoshimasa Takizawa, Cheng-Han Ho, Hiroaki Tachiwana, Hideyuki Matsunami, Wataru Kobayashi, Midori Suzuki, Yasuhiro Arimura, Tetsuya Hori, Tatsuo Fukagawa, Melanie D Ohi …

Structure (London, England : 1993), 28(1) 44-53, Jan 7, 2020 Peer-reviewed
Structural transition of the nucleosome during chromatin remodeling and transcription.

Kobayashi W, Kurumizaka H

Current opinion in structural biology, 59 107-114, Aug, 2019 Peer-reviewed
Structural and biochemical analyses of the nuclear pore complex component ELYS identify residues responsible for nucleosome binding.

Kobayashi W, Takizawa Y, Aihara M, Negishi L, Ishii H, Kurumizaka H

Communications biology, 2 163-163, 2019 Peer-reviewedLead author
Homologous pairing activities of Arabidopsis thaliana RAD51 and DMC1.

Kobayashi W, Liu E, Ishii H, Matsunaga S, Schlögelhofer P, Kurumizaka H

Journal of biochemistry, 165(3) 289-295, Dec, 2018 Peer-reviewedLead author
Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome

Arimura, Yasuhiro, Ikura, Masae, Fujita, Risa, Noda, Mamiko, Kobayashi, Wataru, Horikoshi, Naoki, Sun, Jiying, Shi, Lin, Kusakabe, Masayuki, Harata, Masahiko …

Nucleic acids research, 46(19) 10007-10018, Nov, 2018 Peer-reviewed
Histone H2A variants confer specific properties to nucleosomes and impact on chromatin accessibility

Akihisa Osakabe, Zdravko J Lorković, Wataru Kobayashi, Hiroaki Tachiwana, Ramesh Yelagandula, Hitoshi Kurumizaka, Frédéric Berger

Nucleic Acids Research, 46(15) 7675-7685, Sep 6, 2018 Peer-reviewed
Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2

Martin R. Higgs, Koichi Sato, John J. Reynolds, Shabana Begum, Rachel Bayley, Amalia Goula, Audrey Vernet, Karissa L. Paquin, David G. Skalnik, Wataru Kobayashi …

Molecular Cell, 71(1) 25-41.e6, Jul 5, 2018 Peer-reviewed
Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome.

Arimura Y, Ikura M, Fujita R, Noda M, Kobayashi W, Horikoshi N, Sun J, Shi L, Kusakabe M, Harata M …

Nucleic acids research, 46(19) 10007-10018, Jul, 2018 Peer-reviewed
Replication stress induces accumulation of FANCD2 at central region of large fragile genes

Yusuke Okamoto, Watal M. Iwasaki, Kazuto Kugou, Kazuki K. Takahashi, Arisa Oda, Koichi Sato, Wataru Kobayashi, Hidehiko Kawai, Ryo Sakasai, Akifumi Takaori-Kondo …

NUCLEIC ACIDS RESEARCH, 46(6) 2932-2944, Apr, 2018 Peer-reviewed
SYCP3 regulates strand invasion activities of RAD51 and DMC1

Wataru Kobayashi, Noriko Hosoya, Shinichi Machida, Kiyoshi Miyagawa, Hitoshi Kurumizaka

GENES TO CELLS, 22(9) 799-809, Sep, 2017 Peer-reviewedLead author
RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination

Shojiro Inano, Koichi Sato, Yoko Katsuki, Wataru Kobayashi, Hiroki Tanaka, Kazuhiro Nakajima, Shinichiro Nakada, Hiroyuki Miyoshi, Kerstin Knies, Akifumi Takaori-Kondo …

MOLECULAR CELL, 66(5) 622-+, Jun, 2017 Peer-reviewed
Xeroderma pigmentosum group C protein interacts with histones: regulation by acetylated states of histone H3

Erina Kakumu, Seiya Nakanishi, Hiromi M. Shiratori, Akari Kato, Wataru Kobayashi, Shinichi Machida, Takeshi Yasuda, Naoko Adachi, Naoaki Saito, Tsuyoshi Ikura …

GENES TO CELLS, 22(3) 310-327, Mar, 2017 Peer-reviewed
FANCI-FANCD2 stabilizes the RAD51-DNA complex by binding RAD51 and protects the 5 '-DNA end

Koichi Sato, Mayo Shimomuki, Yoko Katsuki, Daisuke Takahashi, Wataru Kobayashi, Masamichi Ishiai, Hiroyuki Miyoshi, Minoru Takata, Hitoshi Kurumizaka

NUCLEIC ACIDS RESEARCH, 44(22) 10758-10771, Dec, 2016 Peer-reviewed
Chromatin architecture may dictate the target site for DMC1, but not for RAD51, during homologous pairing

Wataru Kobayashi, Motoki Takaku, Shinichi Machida, Hiroaki Tachiwana, Kazumitsu Maehara, Yasuyuki Ohkawa, Hitoshi Kurumizaka

SCIENTIFIC REPORTS, 6 24228, Apr, 2016 Peer-reviewedLead author

Misc.

遺伝情報の維持継承におけるミクロとマクロの統合的理解:生化学の新たな挑戦 RAD51-単鎖DNA-ヌクレオソーム複合体の構造生物学的解析

小林航, 石井初芽, 滝沢由政, 胡桃坂仁志

日本生化学会大会プログラム・講演要旨集, 91回 [2S06m-04], Sep, 2018
リンカーヒストンを含む高次クロマチン構造における相同組換え機構

町田晋一, 高久誉大, 井倉正枝, 孫継英, 鈴木秀和, 小林航, 木野村愛子, 越阪部晃永, 立和名博昭, 浦聖恵 …

日本分子生物学会年会プログラム・要旨集(Web), 36th, 2013
相同組換えにおける高次クロマチンの動的な制御

町田晋一, 高久誉大, 井倉正枝, SUN Jiying, 鈴木秀和, 小林航, 越阪部晃永, 立和名博昭, 浦聖恵, 田代聡 …

日本生化学会大会(Web), 86th, 2013
再構成系によるクロマチンでの相同組換え機構の解析

高久誉大, 町田晋一, 小林航, 林田亮太, 鈴木秀和, 井倉正枝, 越阪部晃永, 立和名博昭, 浦聖恵, 田代聡 …

日本生化学会大会(Web), 85th, 2012

Professional Memberships

Research Projects

核膜孔複合体構成因子ELYSによるヌクレオソームの認識機構解析

若手研究, 科学研究費助成事業(早稲田大学), Apr, 2018 - Mar, 2019

小林航
シナプトネマ複合体構成因子SYCP3による減数分裂期組換えの制御機構解析

研究活動スタート支援, 科学研究費助成事業(早稲田大学), Aug, 2016 - Mar, 2018

小林航
クロマチン構造上における減数分裂期組換えの分子機構

特別研究員奨励費, 日本学術振興会, Apr, 2013 - Mar, 2016

小林航

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Research History

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Misc.

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