2019年2月15日
Design, Synthesis, and Cellular Uptake of Oligonucleotides Bearing Glutathione-Labile Protecting Groups.
Organic letters
- ,
- ,
- ,
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- 巻
- 21
- 号
- 4
- 開始ページ
- 862
- 終了ページ
- 866
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/acs.orglett.8b03501
Glutathione-labile protecting groups for phosphodiester moieties in oligonucleotides were designed, synthesized, and incorporated into oligonucleotides. The protecting groups on the phosphodiester moieties were cleaved in a buffer containing 10 mM glutathione, which was used as a model of intracellular fluid. Cellular uptake of oligonucleotides bearing glutathione-labile protecting groups was strongly affected by the location and number of the protecting groups.
- リンク情報
- ID情報
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- DOI : 10.1021/acs.orglett.8b03501
- ISSN : 1523-7060
- PubMed ID : 30714380