論文

査読有り
2020年6月11日

Carbamate as an accelerating group in intermolecular Pauson-Khand reaction

Tetrahedron Letters
  • Shota Asano
  • ,
  • Kaori Itto-Nakama
  • ,
  • Hirokazu Arimoto

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記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.tetlet.2020.151974

© 2020 Elsevier Ltd The Pauson-Khand reaction (PKR) is a powerful means for the construction of cyclopentenones. However, its applications have been limited to the intramolecular version of this reaction because poor yield and regioselectivity are often the major problems in intermolecular PKR. Here we describe that a carbamate moiety in alkene substrate accelerates this intermolecular PKR. The reaction of N-4-dimethylaminophenyl O-allyl carbamate with alkyne-cobalt complex gave cyclopentenones in high yield (up to 90%) and regioselectivity (>9:1).

リンク情報
DOI
https://doi.org/10.1016/j.tetlet.2020.151974
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85084066798&origin=inward
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85084066798&origin=inward

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