1997年9月
HIV-1 capsid mutants inhibit the replication of wild-type virus at both early and late infection phases
FEBS LETTERS
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- 巻
- 415
- 号
- 2
- 開始ページ
- 231
- 終了ページ
- 234
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/S0014-5793(97)01132-0
- 出版者・発行元
- ELSEVIER SCIENCE BV
In-frame mutations were introduced into various portions of the human immunodeficiency virus type 1 (HIV-1) gag gene, and potentials of the mutants to suppress the replication of wild-type HIV-1 were monitored. In contrast to results obtained with matrix and nucleocapsid mutants, almost all capsid mutants blocked HIV-1 replication completely in single-round replication assays. A capsid mutant designated C6b was demonstrated to be one of the most efficient inhibitors for HIV-1 reported to date, and to be effective at both early and late viral replication phases. T-cells, which are engineered to express the C6b Gag in response to HIV-1 infection, were perfectly resistant to HIV-1. (C) 1997 Federation of European Biochemical Societies.
- リンク情報
- ID情報
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- DOI : 10.1016/S0014-5793(97)01132-0
- ISSN : 0014-5793
- Web of Science ID : WOS:A1997YB59200023