2020年8月
Antioxidative effects of a novel dietary supplement Neumentix in a mouse stroke model.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
- 巻
- 29
- 号
- 8
- 開始ページ
- 104818
- 終了ページ
- 104818
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.jstrokecerebrovasdis.2020.104818
- 出版者・発行元
- ELSEVIER
BACKGROUND: During an acute stroke, reactive oxygen species are overproduced and the endogenous antioxidative defense systems are disrupted. Therefore, antioxidative therapy can be a promising scheme to reduce the severity of stroke. Neumentix is a novel antioxidative supplement produced from a patented mint line and contains a high content of rosmarinic acid (RA). Although Neumentix has proven diverse efficacy and safety in clinical trials, its effect on strokes is unclear. METHODS: Mice that were treated with Neumentix or vehicle for 14 days underwent transient middle cerebral artery occlusion (tMCAO) for 60 min. Mice were sacrificed 5 days after tMCAO. RESULTS: Neumentix preserved body weight after tMCAO, showed a high antioxidative effect in serum, and reduced infarction volume compared to the vehicle. The expression of 4-hydroxy-2-nonenal, Nε-(carboxymethyl) lysine, and 8-hydroxy-2'-deoxyguanosine was reduced in Neumentix-treated mice. CONCLUSION: The antioxidative effect of Neumentix was confirmed. This is the first report to demonstrate the antioxidative effect of Neumentix on strokes.
- リンク情報
-
- DOI
- https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.104818
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/32439352
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000549858500004&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85084741108&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85084741108&origin=inward
- ID情報
-
- DOI : 10.1016/j.jstrokecerebrovasdis.2020.104818
- ISSN : 1052-3057
- eISSN : 1532-8511
- PubMed ID : 32439352
- SCOPUS ID : 85084741108
- Web of Science ID : WOS:000549858500004