論文

査読有り 国際誌
2020年8月17日

Sodium/potassium ratio change was associated with blood pressure change: possibility of population approach for sodium/potassium ratio reduction in health checkup.

Hypertension research : official journal of the Japanese Society of Hypertension
  • Mana Kogure
  • ,
  • Naoki Nakaya
  • ,
  • Takumi Hirata
  • ,
  • Naho Tsuchiya
  • ,
  • Tomohiro Nakamura
  • ,
  • Akira Narita
  • ,
  • Yoko Suto
  • ,
  • Yoko Honma
  • ,
  • Hidemi Sasaki
  • ,
  • Ken Miyagawa
  • ,
  • Yusuke Ushida
  • ,
  • Hiroyuki Ueda
  • ,
  • Atsushi Hozawa

記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41440-020-00536-7

Recently, the sodium (Na)/potassium (K) ratio was reported to be associated with blood pressure (BP). A Na/K ratio self-monitoring device using spot urine was established recently. Here, we assessed whether the urinary Na/K ratio change measured using the Na/K device was associated with BP change in a health checkup setting. We targeted 12,890 participants who attended the health checkup in Tome City, Miyagi between 2017 and 2018. Tome City introduced urinary Na/K ratio measurements during health checkups since 2017. For each year, we compared the baseline characteristics according to the urinary Na/K ratio and BP level. We assessed the relationship between change in urinary Na/K ratio and BP change using multiple regression analyses adjusted for age, sex, and change in body mass index (BMI) and alcohol intake. The average urinary Na/K ratio was significantly lower in 2018 than in 2017 (5.4 ± 3.0 to 4.9 ± 2.2, P < 0.01). The systolic BP of the participants in 2018 (130.9 ± 17.4 mmHg) was lower than that in 2017 (132.1 ± 17.9 mmHg). Moreover, the change in systolic BP and diastolic BP was positively associated with the change in urinary Na/K ratio. In conclusion, the association of the change in urinary Na/K ratio with hypertension and changes in systolic and diastolic BP can be explained by a change in alcohol intake, BMI, and urinary Na/K ratio. Therefore, measuring the urinary Na/K ratio in community settings is a potential population approach for counteracting hypertension.

リンク情報
DOI
https://doi.org/10.1038/s41440-020-00536-7
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32801312

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