KOWADA Toshiyuki

J-GLOBAL         Last updated: Mar 26, 2019 at 10:23
 
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Name
KOWADA Toshiyuki
E-mail
toshiyuki.kowada.d5tohoku.ac.jp
URL
http://db.tohoku.ac.jp/whois/e_detail/430c8345304596570f3a888c2f43f012.html
Affiliation
Tohoku University
Section
Institute of Multidisciplinary Research for Advanced Materials Division of Organic- and Bio-materials Research Cell Functional Molecular Chemistry
Job title
Assistant Professor
Degree
博士(工学)(Kyoto University)
ORCID ID
R-2716-2016

Research Areas

 
 

Academic & Professional Experience

 
Nov 2016
 - 
Today
Assistant Professor, Institute of Multidisciplinary Research for Advanced Materials, Tohoku University
 
Oct 2014
 - 
Oct 2016
Postdoctoral Fellow, School of medicine, Stanford University, USA
 
Apr 2011
 - 
Sep 2014
Specially appointed assistant professor, WPI Immunology Frontier Research Center, Osaka University, Japan
 
Apr 2010
 - 
Mar 2011
Specially appointed researcher, WPI Immunology Frontier Research Center, Osaka University, Japan
 

Education

 
Apr 2005
 - 
Mar 2010
Department of Energy and Hydrocarbon Chemistry, Graduate School, Division of Engineering, Kyoto University
 
Apr 2001
 - 
Mar 2005
Division of Industrial Chemistry, Faculty of Engineering, Kyoto University
 

Awards & Honors

 
Mar 2014
The Naito Foundation Grant for Studying Overseas, 内藤科学技術振興財団
 
Jun 2013
The 8th Annual Meeting of Japanese Society for Chemical Biology, Poster Presentation Award, 日本ケミカルバイオロジー学会
 

Published Papers

 
Light-wavelength-based Quantitative Control of Dihydrofolate Reductase Activity Using Photochromic Isostere of Inhibitor
Takato Mashita, Toshiyuki Kowada, Hiroto Takahashi, Toshitaka Matsui, Shin Mizukami
ChemBioChem      Jan 2019   [Refereed]
Hiroki Maeda, Toshiyuki Kowada, Junichi Kikuta, Masayuki Furuya, Mai Shirazaki, Shin Mizukami, Masaru Ishii, Kazuya Kikuchi
Nat. Chem. Biol.   12(8) 579-585   Aug 2016   [Refereed]
Toshiyuki Kowada, Hiroki Maeda, Kazuya Kikuchi
Chem. Soc. Rev.   44(14) 4953-4972   2015   [Refereed]
Junichi Kikuta, Yoh Wada, Toshiyuki Kowada, Ze Wang, Ge-Hong Sun-Wada, Issei Nishiyama, Shin Mizukami, Nobuhiko Maiya, Hisataka Yasuda, Atsushi Kumanogoh, Kazuya Kikuchi, Ronald N. Germain, Masaru Ishii
J. Clin. Invest.   123(2) 866-873   Feb 2013   [Refereed]
Koji Miki, Tsuyoshi Matsushita, Yuki Inoue, Yoshinori Senda, Toshiyuki Kowada, Kouichi Ohe
Chem. Commun.   49(80) 9092-9094   2013   [Refereed]
Toshiyuki Kowada, Junichi Kikuta, Atsuko Kubo, Masaru Ishii, Hiroki Maeda, Shin Mizukami, Kazuya Kikuchi
J. Am. Chem. Soc.   133(44) 17772-17776   Nov 2011   [Refereed]
Toshiyuki Kowada, Shuhei Yamaguchi, Hiroki Fujinaga, Kouichi Ohe
Tetrahedron   67(17) 3105-3110   Apr 2011   [Refereed]
Koji Miki, Michiyasu Fujita, Yuki Inoue, Yoshinori Senda, Toshiyuki Kowada, Kouichi Ohe
J. Org. Chem.   75(10) 3537-3540   May 2010   [Refereed]
Toshiyuki Kowada, Kouichi Ohe
Bull. Korean Chem. Soc.   31(3) 577-581   Mar 2010   [Refereed]
Toshiyuki Kowada, Toshihisa Toshihisa, Kouichi Ohe
J. Org. Chem.   75(3) 906-913   Feb 2010   [Refereed]
Toshiyuki Kowada, Shuhei Yamaguchi, Kouichi Ohe
Org. Lett.   12(2) 296-299   Jan 2010   [Refereed]
Koji Miki, Yoshinori Senda, Toshiyuki Kowada, Kouichi Ohe
Synlett   (12) 1937-1940   Jul 2009   [Refereed]
Toshiyuki Kowada, Yoshio Matsuyama, Kouichi Ohe
Synlett   (12) 1902-1906   Jul 2008   [Refereed]

Misc

 
pH 感受性蛍光プローブを用いた破骨細胞活性の生体イメージング
Toshiyuki Kowada, Hiroki Maeda, Kazuya Kikuchi
Chemical Biology   9(1) 3-6   2016
二光子励起顕微鏡で捉える硬い骨の中の生命現象
Toshiyuki KOWADA
Chemistry & Chemical Industry   67(8) 698-698   Aug 2014

Books etc

 
実験医学増刊「生きてるものは全部観る!イメージングの選び方・使い方100+」
Toshiyuki Kowada, Shin Mizukami (Part:Joint Work, 第9章「57. タンパク質ラベル化技術―HaloTag, SNAP-tag, tetracysteine tag」)
Yodosha   Dec 2018   
Optical Probes in Biology, Edited by Jin Zhang, Sohum Mehta, Carsten Schultz
Toshiyuki KOWADA, Hiroki MAEDA, Kazuya KIKUCHI (Part:Joint Work, Chapter 13 “Chemical probes for fluorescence imaging in living mice”)
CRC Press   2015   ISBN:9781466510111
実験医学別冊「in vivo イメージング実験プロトコール 原理と導入のポイントから 2光子顕微鏡の応用まで」
KOWADA Toshiyuki, KIKUCHI Kazuya (Part:Joint Work, 基本編 ―原理と機器選択― 5 in vivoイメージングに適した化学プローブの選択)
Yodosha Company Limited   Dec 2012   ISBN:978-4-7581-0185-1

Conference Activities & Talks

 
Development of fluorescent probe for visualization and quantitative analysis of zinc ion in intracellular organelles
Toshiyuki Kowada, Tomomi Watanabe, Toshitaka Matsui, Shin Mizukami
The 2nd Symposium for World Leading Research Centers   17 Feb 2019   
Quantitative analysis of free zinc ion concentration in living cells using novel targetable fluorescent probe
Tomomi Watanabe, Toshiyuki Kowada, Rong Liu, Toshitaka Matsui, Shin Mizukami
15th International Symposium on Applied Bioinorganic Chemistry   4 Jun 2019   
Development of methotrexate derivatives for reversible photo-control of binding to protein
Takato Mashita, Toshiyuki Kowada, Hiroto Takahashi, Toshitaka Matsui, Shin Mizukami
日本化学会第99春季年会   18 Mar 2019   
Fluorescent probes for quantitative measurement of local pH in cells
Risa Ito, Toshiyuki Kowada, Toshitaka Matsui, Shin Mizukami
第12回バイオ関連化学シンポジウム   9 Sep 2018   
Photo-regulation of protein dimerization using protein labeling system
Toshiyuki Kowada, Keisuke Arai, Akimasa Yoshimura, Toshitaka Matsui, Kazuya Kikuchi, Shin Mizukami
The 99th CSJ Annual Meeting   18 Mar 2019   
Development of fluorescent probe for visualizing intracellular Mg2+ dynamics
Keisuke Wakabayashi, Toshiyuki Kowada, Shin Mizukami
Tohoku University's Chemistry Summer School 2018   27 Aug 2018   
Visualization of zinc ion in intracellular organelles
Tomomi Watanabe, Toshiyuki Kowada, Toshitaka Matsui, Shin Mizukami
The 99th CSJ Annual Meeting   16 Mar 2019   
Development of fluorescent probes for real-time and quantitative measurement of local pH changes in cell
Risa Ito, Toshiyuki Kowada, Shin Mizukami
Tohoku University's Chemistry Summer School 2018   27 Aug 2018   
Development of fluorescent probes for visualization of zinc ion in intracellular organelles
Tomomi Watanabe, Toshiyuki Kowada, Toshitaka Matsui, Shin Mizukami
Tohoku University's Chemistry Summer School 2018   27 Aug 2018   
細胞内オルガネラにおける亜鉛イオン検出を可能とする小分子蛍光プローブの開発
小和田 俊行
第6回アライアンス若手研究交流会   1 Nov 2018   
Development of self-assembling peptide for controlling aggregation state by light
Yuri Hashimoto, Toshiyuki Kowada, Shin Mizukami
Tohoku University's Chemistry Summer School 2018   27 Aug 2018   
Photo-switchable Dihydrofolate Reductase (DHFR) Inhibitor
Takato Mashita, Toshiyuki Kowada, Hiroto Takahashi, Toshitaka Matsui, Shin Mizukami
Tohoku University's Chemistry Summer School 2018   27 Aug 2018   
Development of a protein ligand capable of photoreversible binding and dissociation
Takato Mashita, Toshiyuki Kowada, Hiroto Takahashi, Toshitaka Matsui, Shin Mizukami
第12回バイオ関連化学シンポジウム   10 Sep 2018   
Creation of light-switchable protein degradation system
小和田 俊行
新学術領域「化学コミュニケーションのフロンティア」第3回公開シンポジウム   27 Jun 2018   
Visualization of zinc ion dynamics in intracellular organelles
渡邊 朝美, 小和田 俊行, 松井 敏高, 水上 進
第28回金属の関与する生体関連反応シンポジウム(SRM2018)   29 Jun 2018   
Development of functional small-molecule fluorescent probes for analysis of biological functions [Invited]
小和田俊行
平成30年度東日本分析化学若手交流会   6 Jul 2018   
Live-cell fluorescence imaging of zinc ions using localizable small-molecule probe
Toshiyuki Kowada, Tomomi Watanabe, Toshitaka Matsui, Shin Mizukami
5th CWRU-Tohoku Joint Workshop   2 Aug 2018   
Development of Reversibly Photoresponsive Drug
間下 貴斗, 小和田 俊行, 高橋 泰人, 松井 敏高, 水上 進
第29回 万有仙台シンポジウム   9 Jun 2018   
Synthesis and functional assessment of a photoresponsive compound for bioanalytical applications
Takato Mashita, Toshiyuki Kowada, Hiroto Takahashi, Toshitaka Matsui, Shin Mizukami
日本化学会第98春季年会   22 Mar 2018   
Synthesis and functional assessment of a photoresponsive compound for bioanalytical applications
Takato Mashita, Toshiyuki Kowada, Hiroto Takahashi, Toshitaka Matsui, Shin Mizukami
日本化学会第98春季年会   20 Mar 2018   
Real-time intravital imaging of pH-variation associated with osteoclast activity using small- molecule fluorescent probe [Invited]
Toshiyuki Kowada
The 21st International Symposium on Institute for Integrated Cell-Material Sciences   3 Jun 2016   

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology (MEXT): Grant-in-Aid for Scientific Research
Project Year: Apr 2018 - Mar 2020    Investigator(s): KOWADA Toshiyuki
Development of chemical tools for photocontrol of protein-protein interaction
Japan Society for the Promotion of Science: Grant-in-Aid for Scientific Research
Project Year: Apr 2017 - Mar 2020    Investigator(s): KOWADA Toshiyuki
Development of fluorescent probes for visualizing low-pH environment and their application in intravital imaging
Japan Society for the Promotion of Science: Grant-in-Aid for Scientific Research
Project Year: Apr 2012 - Mar 2014    Investigator(s): KOWADA Toshiyuki