Tsubasa Watanabe

Profile Information

Affiliation: Kyoto University

Degree: 博士(医学)(Mar, 2017, 京都大学)

J-GLOBAL ID: 201701014070122245
researchmap Member ID: 7000019577

Major Research Interests

Major Research Areas

Life sciences / Radiology /

Major Research History

Sep, 2023 - Present

Kyoto University
Oct, 2020 - Aug, 2023

Kyoto University
Apr, 2017 - Sep, 2020

Assistant Professor, Institute for Integrated Radiation and Nuclear Science, Kyoto University
Oct, 2017 - Sep, 2019

Post-doctoral researcher, Department of Radiation Oncology, Albert-Ludwigs-Universität Freiburg
Apr, 2014 - Mar, 2017

Research fellow (DC1), Japan Society for the Promotion of Science
Apr, 2011 - Mar, 2013

Therapeutic Radiology, Hospital, Kyoto University
Apr, 2009 - Mar, 2011

Hospital, Kyoto University

Major Education

Apr, 2013 - Mar, 2017

Graduate School of Medicine, Graduate School of Medicine, Kyoto University
Apr, 2003 - Mar, 2009

Department of Medical Science, Faculty of Medicine, Kyoto University

Major Committee Memberships

Dec, 2022 - Present

Managing Editor, Journal of Radiation Research
Dec, 2022 - Present

学術委員会, 日本放射線腫瘍学会
Dec, 2022 - Present

編集委員会, 日本放射線腫瘍学会
Jun, 2022 - Present

代議員, 日本放射線腫瘍学会
Apr, 2022 - Present

薬剤評価標準化対応委員会, 日本中性子捕捉療法学会
Jun, 2021 - Present

広報委員会, 日本中性子捕捉療法学会
2016 - Present

教育委員会, 日本中性子捕捉療法学会

Major Papers

Proposal of recommended experimental protocols for in vitro and in vivo evaluation methods of boron agents for neutron capture therapy.

Yoshihide Hattori, Tooru Andoh, Shinji Kawabata, Naonori Hu, Hiroyuki Michiue, Hiroyuki Nakamura, Takahiro Nomoto, Minoru Suzuki, Takushi Takata, Hiroki Tanaka …

Journal of radiation research, Sep 16, 2023
Pharmacokinetic Study of 14C-Radiolabeled p-Boronophenylalanine (BPA) in Sorbitol Solution and the Treatment Outcome of BPA-Based Boron Neutron Capture Therapy on a Tumor-Bearing Mouse Model.

Tsubasa Watanabe, Tomohiro Yoshikawa, Hiroki Tanaka, Yuko Kinashi, Genro Kashino, Shin-Ichiro Masunaga, Toshimitsu Hayashi, Koki Uehara, Koji Ono, Minoru Suzuki

European journal of drug metabolism and pharmacokinetics, 48(4) 443-453, Jul, 2023
Correlation between the expression of LAT1 in cancer cells and the potential efficacy of boron neutron capture therapy

Tsubasa Watanabe, Yu Sanada, Yoshihide Hattori, Minoru Suzuki

Journal of Radiation Research, 64(1) 91-98, Nov 14, 2022 Peer-reviewedLead authorCorresponding author
Anti-tumor effect of boron neutron capture therapy in pelvic human colorectal cancer in a mouse model.

Jun Arima, Kohei Taniguchi, Masashi Yamamoto, Tsubasa Watanabe, Yusuke Suzuki, Hiroki Hamamoto, Yosuke Inomata, Hideki Kashiwagi, Shinji Kawabata, Keitaro Tanaka …

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 154 113632-113632, Sep 2, 2022
The mutual relationship between the host immune system and radiotherapy: stimulating the action of immune cells by irradiation.

Tsubasa Watanabe, Genki Edward Sato, Michio Yoshimura, Minoru Suzuki, Takashi Mizowaki

International Journal of Clinical Oncology, 28(2) 201-208, May 12, 2022 Peer-reviewedInvitedLead authorCorresponding author
Deep Abscopal Response to Radiotherapy and anti-PD-1 in an Oligometastatic Melanoma Patient With Unfavorable Pretreatment Immune Signature

Tsubasa Watanabe, Elke Firat, Jutta Scholber, Simone Gaedicke, Corinne Heinrich, Ren Luo, Nicolas Ehrat, Gabriele Multhoff, Annette Schmitt-Graeff, Anca-Ligia Grosu …

Cancer Immunology Immunotherapy, 69 1823-1832, Apr, 2020 Peer-reviewedLead author
Cisplatin Facilitates Radiation-Induced Abscopal Effects in Conjunction with PD-1 Checkpoint Blockade Through CXCR3/CXCL10-Mediated T-cell Recruitment.

Ren Luo, Elke Firat, Simone Gaedicke, Elena Guffart, Tsubasa Watanabe, Gabriele Niedermann

Clinical cancer research : an official journal of the American Association for Cancer Research, 25(23) 7243-7255, Dec 1, 2019 Peer-reviewed
Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8+ T-Cell-Dependent Tumor Activity.

Tsubasa Watanabe, Simone Gaedicke, Elena Guffart, Elke Firat, Gabriele Niedermann

Clinical Cancer Research, 26 945-956, Nov 6, 2019 Peer-reviewedLead author
Comparison of the pharmacokinetics between L-BPA and L-FBPA using the same administration dose and protocol: a validation study for the theranostic approach using [18F]-L-FBPA positron emission tomography in boron neutron capture therapy.

Tsubasa Watanabe, Yoshihide Hattori, Youichiro Ohta, Miki Ishimura, Yosuke Nakagawa, Yu Sanada, Hiroki Tanaka, Satoshi Fukutani, Shin-Ichiro Masunaga, Masahiro Hiraoka …

BMC cancer, 16(1) 859-859, Nov 8, 2016 Peer-reviewedLead author
L-Phenylalanine preloading reduces the (10)B(n, α)(7)Li dose to the normal brain by inhibiting the uptake of boronophenylalanine in boron neutron capture therapy for brain tumours.

Tsubasa Watanabe, Hiroki Tanaka, Satoshi Fukutani, Minoru Suzuki, Masahiro Hiraoka, Koji Ono

Cancer letters, 370(1) 27-32, Jan 1, 2016 Peer-reviewedLead author
Pharmacokinetic model of myocardial Tc-99m-sestamibi washout

Tsubasa Watanabe, Hajime Monzen, Masatake Hara, Takashi Mizowaki, Masahiro Hiraoka

ANNALS OF NUCLEAR MEDICINE, 27(3) 279-284, Apr, 2013 Peer-reviewedLead author
Relationship Between Pancreatic Perfusion Parameters and Clinical Complications of Severe Acute Pancreatitis

Tsubasa Watanabe, Yoshihisa Tsuji, Naoki Takahashi, Tsukasa Yoshida, Masashi Tamaoki, Osamu Kikuchi, Yuji Watanabe, Yuzo Kodama, Hiroyoshi Isoda, Hiroshi Yamamoto …

PANCREAS, 42(1) 180-182, Jan, 2013 Peer-reviewedLead author
A case of long-term survival of metastatic desmoplastic small round cell tumor treated with multimodal therapy

Tsubasa Watanabe, Shin'ichi Miyamoto, Koji Kitagori, Takahiro Horimatsu, Shuko Morita, Yoko Mashimo, Yasumasa Ezoe, Manabu Muto, Tsutomu Chiba

ONCOLOGY LETTERS, 3(1) 30-34, Jan, 2012 Peer-reviewedLead author
Relationship Between Serum Angiopoietin-2 Level and Perfusion CT Parameters in Severe Acute Pancreatitis

Tsubasa Watanabe, Yoshihisa Tsuji, Yuzo Kodama, Hiroyoshi Isoda, Hiroshi Yamamoto, Tsutomu Chiba

AMERICAN JOURNAL OF GASTROENTEROLOGY, 106(10) 1859-1861, Oct, 2011 Peer-reviewedLead author

Major Misc.

Study of Optimal Irradiation Method for Superficial Tumors Using a Hydrogel Bolus in Cyclotron-based BNCT

SASAKI Akinori, TAKATA Takushi, TAMARI Yuki, WATANABE Tsubasa, HU Naonori, HU Naonori, KAWABATA Shinji, KUDO Yoshihiro, MITSUMOTO Toshinori, MATSUBAYASHI Nishiki …

日本放射線技術学会総会学術大会予稿集, 77th, 2021
良好なアブスコパル効果を認めた転移性悪性黒色腫患者の末梢血免疫反応の解析

渡邉翼, 渡邉翼, 吉村通央, 溝脇尚志, 鈴木実, NIEDERMANN Gabriele

日本癌治療学会学術集会(Web), 58th, 2020

Books and Other Publications

ベッドサイド泌尿器科学(改定第5版)

(Role: Joint author, 腫瘍放射線治療学(免疫療法との併用))

南江堂

Major Presentations

ホウ素中性子捕捉療法の治療効果改善のための基礎放射線生物研究

渡邉翼

3. 第61回日本癌治療学会学術集会, Oct, 2023 Invited
シングルセルRNAseq解析による腫瘍細胞のLAT1発現と細胞周期との関連解明

渡邉翼

第19回日本中性子捕捉療法学会, Jul 14, 2023
ホウ素中性子捕捉療法の課題と解決法の模索

渡邉翼

日本放射線影響学会第65回大会, Sep 15, 2022 Invited
モーニングセミナー: BNCTの生物学

渡邉翼

日本放射線腫瘍学会夏季セミナー, Aug 6, 2022 Invited
Educational Symposium「がん免疫治療における放射線照射の副次的効果」

渡邉翼

第19回日本臨床腫瘍学会学術集会, Feb 19, 2022 Invited
教育講演「いまさら聞けない化学放射線療法および免疫療法との併用について」

渡邉翼

日本医学物理学会教育セミナー2021, Dec 18, 2021 Invited
シンポジウム4 「高精度放射線治療における放射線生物学」「免疫療法時代における高精度放射線治療の役割」

渡邉翼

第34回高精度放射線外部照射部会学術大会, Mar 21, 2021 Invited
臓器別シンポジウム「免疫療法時代における局所療法の意義」- 「放射線照射と免疫療法併用における放射線治療の役割と可能性」

渡邉翼

第58回癌治療学会, Oct 22, 2020 Invited
放射線照射と免疫療法併用における腫瘍組織内代謝競合の役割

渡邉翼

日本放射線腫瘍学会第33回学術大会, Oct 1, 2020 Invited
IDO inhibition strongly enhances effects of combined hRT and PD1/PD-L1 checkpoint blockades

Tsubasa Watanabe, Gabriele Niedermann

ESTRO conference 38 (European Society for Radiotherapy & Oncology), Apr 27, 2019

Major Professional Memberships

Oct, 2019 - Present

日本ハイパーサーミア学会
Oct, 2013 - Present

国際中性子捕捉療法学会
Apr, 2013 - Present

日本中性子捕捉療法学会
Apr, 2011 - Present

Japan Society of Clinical Oncology
Apr, 2011 - Present

国際癌治療増感研究会
Apr, 2011 - Present

日本医学放射線学会
Jun, 2009 - Present

日本放射線腫瘍学会

Major Research Projects

免疫細胞のホウ素薬剤取込能を評価しホウ素中性子捕捉療法後の免疫への影響を解明する

文部科学省科学研究費助成事業(科研費), 基盤研究(C), Apr, 2023 - Mar, 2026
中性子捕捉ナイフシステムを用いた非腫瘍性難治性疾患の治療法確立

2021年度医学系研究助成(基礎), 武田科学振興財団, Nov, 2021 - Oct, 2022
癌微小環境を標的とした中性子捕捉療法の開発

第33回SGHがん研究助成, 公益財団法人SGH財団, Nov, 2021 - Oct, 2022
ホウ素中性子捕捉療法後に起こるX線照射後には認められない新規宿主免疫賦活機序を解明する

がんの予防及び診断と治療に関する基礎的研究に対する研究助成, 小林がん学術振興会, Apr, 2020 - Mar, 2021
悪性黒色腫に対するホウ素中性子捕捉療法後の宿主免疫賦活反応の解析

がん研究助成奨励金, 大阪対がん協会, Apr, 2020 - Mar, 2021
ホウ素中性子捕捉療法により誘導される新規宿主腫瘍免疫賦活効果の同定

科学研究費助成事業(科研費) 若手研究, 文部科学省, Apr, 2019 - Mar, 2021
ホウ素中性子捕捉療法の治療に用いるホウ素薬剤の腫瘍組織不均一性機序を解明する

科学研究費助成事業(科研費) 研究活動スタート支援, 文部科学省, Apr, 2017 - Mar, 2019
腫瘍透過ペプチド修飾ホウ素リポソームを用いたがん細胞選択的中性子捕捉剤の開発

特別研究員奨励費, 日本学術振興会, Apr, 2014 - Mar, 2017

Profile Information

Major Research Interests

Major Research Areas

Major Research History

Major Education

Major Committee Memberships

Major Papers

Major Misc.

Books and Other Publications

Major Presentations

Major Professional Memberships

Major Research Projects

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