2016
Spatzle-Processing Enzyme-independent Activation of the Toll Pathway in Drosophila Innate Immunity
CELL STRUCTURE AND FUNCTION
- ,
- Volume
- 41
- Number
- 1
- First page
- 55
- Last page
- 60
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1247/csf.16002
- Publisher
- JAPAN SOC CELL BIOLOGY
The Toll pathway regulates innate immunity in insects and vertebrates. The Drosophila Toll receptor is activated by a processed form of a ligand, Spatzle. Spatzle-processing enzyme (SPE) is the only enzyme identified to date that functions in converting Spatzle to an active form during the immune response. In the present study, Toll activation induced by immune challenge was almost suppressed in spatzle mutant larvae and adults, whereas it was present in SPE mutant larvae challenged with Micrococcus luteus and adults challenged with Bacillus subtilis. Our data suggest that an unidentified protease besides SPE processes Spatzle under conditions of microbial challenge.
- Link information
- ID information
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- DOI : 10.1247/csf.16002
- ISSN : 0386-7196
- eISSN : 1347-3700
- Web of Science ID : WOS:000375801300002