論文

査読有り 国際誌
2019年7月

Albumin-bilirubin score indicates liver fibrosis staging and prognosis in patients with chronic hepatitis C.

Hepatology research : the official journal of the Japan Society of Hepatology
  • Koji Fujita
  • ,
  • Kyoko Oura
  • ,
  • Hirohito Yoneyama
  • ,
  • Tingting Shi
  • ,
  • Kei Takuma
  • ,
  • Mai Nakahara
  • ,
  • Tomoko Tadokoro
  • ,
  • Takako Nomura
  • ,
  • Asahiro Morishita
  • ,
  • Kunihiko Tsutsui
  • ,
  • Takashi Himoto
  • ,
  • Tsutomu Masaki

49
7
開始ページ
731
終了ページ
742
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/hepr.13333

AIM: Albumin-bilirubin (ALBI) grade was investigated to predict prognosis of patients with cirrhosis. It was defined using the ALBI score calculated based on serum total bilirubin and albumin, which represent liver function. The diagnostic accuracy for liver fibrosis staging in patients with chronic hepatitis using the ALBI score has not been investigated well. This study aimed to evaluate the diagnostic abilities of the ALBI score for liver fibrosis staging in chronic hepatitis and cirrhosis in Japanese patients with hepatitis C virus (HCV) infection. METHODS: Japanese patients with HCV infection who underwent liver biopsy examinations were enrolled in a retrospective study. Fibrosis staging and activity grading were assessed using the modified METAVIR score. The ALBI score was calculated according to the following equation: Log10 total bilirubin (μmol/L) × 0.66 + albumin (g/L) × (-0.085). RESULTS: A total of 382 patients were enrolled in this study. The ALBI score differentiated fibrosis stage 4 from 3 and stage 3 from 2 (P < 0.05). When an ALBI score of -2.125 was adopted as a cut-off value, the sensitivity and specificity were 73.2% and 87.1%, respectively, with a positive likelihood ratio of 5.67 to differentiate stage 4 from stages 1-3. Kaplan-Meier analysis showed that smaller ALBI scores at baseline correlated with better hepatocellular carcinoma (HCC)-free and overall survival (P < 0.05). CONCLUSIONS: The ALBI score indicates liver fibrosis staging in Japanese patients with HCV infection. Furthermore, smaller ALBI scores predict better HCC-free survival and overall survival. The ALBI score has the potential to expand its application from cirrhosis to chronic hepatitis.

リンク情報
DOI
https://doi.org/10.1111/hepr.13333
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30892804
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851801

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