論文

査読有り 国際誌
2019年1月

Complement Component 3 as a Surrogate Hallmark for Metabolic Abnormalities in Patients with Chronic Hepatitis C.

Annals of clinical and laboratory science
  • Takashi Himoto
  • ,
  • Eiichiro Hirakawa
  • ,
  • Koji Fujita
  • ,
  • Teppei Sakamoto
  • ,
  • Takako Nomura
  • ,
  • Asahiro Morishita
  • ,
  • Hirohito Yoneyama
  • ,
  • Reiji Haba
  • ,
  • Tsutomu Masaki

49
1
開始ページ
79
終了ページ
88
記述言語
英語
掲載種別
研究論文(学術雑誌)

OBJECTIVE: We investigated the correlation between serum complement component 3 (C3) levels and metabolic and histological abnormalities in patients with chronic hepatitis C (CH-C). METHODS: Obesity and insulin resistance were estimated by calculating body mass index (BMI) and the values of the homeostasis model for assessment of insulin resistance (HOMA-IR), respectively. Severity of hepatic steatosis and fibrosis were evaluated by New Inuyama Classification and the classification proposed by Brunt and colleagues, respectively. The degree of hepatic C3 expression was examined, using an immunohistochemical procedure. RESULTS: Serum C3 levels were significantly correlated with BMI, HOMA-IR value, and serum triglyceride levels in CH-C patients. Histological analysis revealed that serum C3 levels were significantly elevated in proportion to the severity of hepatic steatosis in such patients. The serum C3 level tended to increase as the severity of hepatic fibrosis progressed. However, the degree of C3 expression in hepatocytes was not associated with serum C3 level among those patients. CONCLUSIONS: These results suggest that the elevation of serum C3 levels may reflect obesity, insulin resistance, and/or hepatic steatosis in patients with CH-C, and that the increase in the synthesis of C3 may derive from the activation of cells other than hepatocytes in those patients.

リンク情報
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30814081

エクスポート
BibTeX RIS