2018年1月1日
Dehydropropylpantothenamide isolated by a co-culture of Nocardia tenerifensis IFM 10554T in the presence of animal cells
Journal of Natural Medicines
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- 巻
- 72
- 号
- 1
- 開始ページ
- 280
- 終了ページ
- 289
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s11418-017-1161-y
© 2017, The Japanese Society of Pharmacognosy and Springer Japan KK, part of Springer Nature. A new amide, named dehydropropylpantothenamide (1), was obtained by a co-culture of Nocardia tenerifensis IFM 10554T in the presence of the mouse macrophage-like cell line J774.1 in modified Czapek-Dox (mCD) medium. Compound 1 was synthesized from d-pantothenic acid calcium salt in 6 steps. The absolute configuration of natural compound 1 was determined by comparisons of the optical rotation and CD spectra of synthetic 1. In the present study, a new method for producing secondary metabolites was demonstrated using a “co-culture” in which the genus Nocardia was cultured in the presence of an animal cell line.
- リンク情報
- ID情報
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- DOI : 10.1007/s11418-017-1161-y
- ISSN : 1340-3443
- eISSN : 1861-0293
- PubMed ID : 29209902
- SCOPUS ID : 85037657559