2014年4月
Pharmacological Characterization of Standard Analgesics on Oxaliplatin-Induced Acute Cold Hypersensitivity in Mice
JOURNAL OF PHARMACOLOGICAL SCIENCES
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 124
- 号
- 4
- 開始ページ
- 514
- 終了ページ
- 517
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1254/jphs.13249SC
- 出版者・発行元
- JAPANESE PHARMACOLOGICAL SOC
Oxaliplatin, a platinum-based chemotherapeutic agent, causes an acute peripheral neuropathy triggered by cold in almost all patients during or within hours after its infusion. We recently reported that a single administration of oxaliplatin induced cold hypersensitivity 2 h after the administration in mice. In this study, we examined whether standard analgesics relieve the oxaliplatin-induced acute cold hypersensitivity. Gabapentin, tramadol, mexiletine, and calcium gluconate significantly inhibited and morphine and milnacipran decreased the acute cold hypersensitivity, while diclofenac and amitriptyline had no effects. These results suggest that gabapentin, tramadol, mexiletine, and calcium gluconate are effective against oxaliplatin-induced acute peripheral neuropathy.
- リンク情報
- ID情報
-
- DOI : 10.1254/jphs.13249SC
- ISSN : 1347-8613
- eISSN : 1347-8648
- PubMed ID : 24671055
- Web of Science ID : WOS:000336344100013