論文

査読有り 招待有り
2016年8月

Concise Review: Stem Cells and Epithelial-Mesenchymal Transition in Cancer: Biological Implications and Therapeutic Targets

STEM CELLS
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回数 : 163
  • Ryo Sato
  • ,
  • Takashi Semba
  • ,
  • Hideyuki Saya
  • ,
  • Yoshimi Arima

34
8
開始ページ
1997
終了ページ
2007
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/stem.2406
出版者・発行元
WILEY

Cancer stem cells (CSCs) constitute a small subpopulation of cancer cells with stem-like properties that are able to self-renew, generate differentiated daughter cells, and give rise to heterogeneous tumor tissue. Tumor heterogeneity is a hallmark of cancer and underlies resistance to anticancer therapies and disease progression. The epithelial-mesenchymal transition (EMT) is a reversible phenomenon that is mediated by EMT-inducing transcription factors (EMT-TFs) and plays an important role in normal organ development, wound healing, and the invasiveness of cancer cells. Recent evidence showing that overexpression of several EMT-TFs is associated with stemness in cancer cells has suggested the existence of a link between EMT and CSCs. In this review, we focus on the roles of CSCs and EMT signaling in driving tumor heterogeneity. A better understanding of the dynamics of both CSCs and EMT-TFs in the generation of tumor heterogeneity may provide a basis for the development of new treatment options for cancer patients.

リンク情報
DOI
https://doi.org/10.1002/stem.2406
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000380767600001&DestApp=WOS_CPL
ID情報
  • DOI : 10.1002/stem.2406
  • ISSN : 1066-5099
  • eISSN : 1549-4918
  • Web of Science ID : WOS:000380767600001

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