論文

査読有り
2020年2月12日

Non-small-cell Lung Cancer with Severe Skin Manifestations Related to Radiation Recall Dermatitis after Atezolizumab Treatment: A Case Report.

Internal medicine (Tokyo, Japan)
  • Kei Nakashima
  • Koichi Saruwatari
  • Ryo Sato
  • Kosuke Imamura
  • Ikko Kajihara
  • Satoshi Fukusima
  • Tetsuo Saito
  • Shiho Ishizuka
  • Daisuke Tamanoi
  • Takayuki Jodai
  • Shohei Hamada
  • Yusuke Tomita
  • Sho Saeki
  • Hidenori Ichiyasu
  • Natsuo Oya
  • Hironobu Ihn
  • Takuro Sakagami
  • 全て表示

記述言語
英語
掲載種別
DOI
10.2169/internalmedicine.3937-19

Radiation recall dermatitis (RRD) is an inflammatory reaction that occurs at previously irradiated skin regions after drug administration. We herein report a patient with non-small-cell lung cancer treated previously with thoracic radiotherapy who developed severe RRD induced by atezolizumab (anti-programmed death 1 ligand 1 [PD-L1] antibody). Immunohistochemistry of the skin biopsy showed dermatitis with infiltration of CD8+ lymphocytes, suggesting that atezolizumab might provoke an immune-related inflammatory reaction at previously irradiated skin regions. When administering anti-PD-L1 antibody to patients who have undergone radiotherapy previously, physicians should carefully monitor the irradiated skin for the potential occurrence of RRD.

リンク情報
DOI
https://doi.org/10.2169/internalmedicine.3937-19
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32051381
ID情報
  • DOI : 10.2169/internalmedicine.3937-19
  • PubMed ID : 32051381

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