論文

査読有り 国際誌
2021年5月

A case of a giant congenital melanocytic nevus treated by curettage with the application of cultured epidermal autografts before 6 months of age

Plastic and Reconstructive Surgery Global Open
  • Fujito H
  • ,
  • Yamanaka H
  • ,
  • Tsuge I
  • ,
  • Katsube M
  • ,
  • Sakamoto M
  • ,
  • Fujimoto M
  • ,
  • Morimoto N

9
5
開始ページ
e3600
終了ページ
記述言語
英語
掲載種別
DOI
10.1097/GOX.0000000000003600

Curettage is common in the treatment of a giant congenital melanocytic nevus (GCMN) in infants and should generally be performed before 6 months of age. Post-curettage retarded epithelialization often interferes with the ability to perform multiple operations within a short interval, and thus, it is difficult to treat large lesions in the neonatal period. We herein report a case of a GCMN comprising 20% of the total body surface area, which required multi-stage curettage, in which a cultured epithelial autograft was used to promote epithelialization of the post-curettage wound. The patient was a 1-month-old boy with a GCMN in his head, neck, chest, back, buttock, left upper arm, and a few satellite lesions. A four-stage operation was performed between 3 and 6 months of age; the cultured epithelial autograft took well after each operation, and complete epithelialization was observed at postoperative days 20, 23, 27, and 12, respectively. Seven months after the last surgery, hypertrophic scar formation was only observed in a small area of the left upper arm without axillary contracture. The color of the treated area improved, except for slight partial re-pigmentation. A skin biopsy was obtained from the re-pigmented area. The results demonstrated that nevus cells remained in the basal layer of the epidermis, hair follicles, and deep layer of the remaining dermis, suggesting that the recurrent nevus cells in the regenerated epidermis migrated from hair follicles. We conclude that the combination of curettage and the application of a cultured epithelial autograft is a promising option for GCMN treatment.

リンク情報
DOI
https://doi.org/10.1097/GOX.0000000000003600
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34881152
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647890
ID情報
  • DOI : 10.1097/GOX.0000000000003600
  • PubMed ID : 34881152
  • PubMed Central 記事ID : PMC8647890

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