Shin'ichi Ozaki

Profile Information

Affiliation: Yamaguchi University

Degree: Ph.D.（Chemistry）(Texas A&M University)
学士（理工学）(慶應義塾大学)

Researcher number: 40280581
J-GLOBAL ID: 201801008069529770
researchmap Member ID: 7000021813

Research Interests

Biological Chemistry

Research Areas

Life sciences / Bioorganic chemistry /

Research History

Sep, 1987 - Feb, 1989

University of Maryland (College Park)
Sep, 1989 - Dec, 1992

Texas A&M University (Department of Chemistry)
Jan, 1993 - Mar, 1995

Department of Pharmaceutical Chemistry, University of California (San Francisco, UCSF Medical Center)
Apr, 1995 - Apr, 1999

助手, 岡崎国立研究機構分子科学研究所
May, 1999 - Jul, 2002

Yamagata University

Papers

Biosynthesis of dillapiole/apiole in dill (Anethum graveolens): characterization of regioselective phenylpropene O-methyltransferase

Takao Koeduka, Bunta Watanabe, Konomi Shirahama, Masaru Nakayasu, Shiro Suzuki, Takumi Furuta, Hideyuki Suzuki, Kenji Matsui, Tomoyuki Kosaka, Shin ichi Ozaki

Plant Journal, 113(3) 562-575, Feb, 2023
Structural basis for substrate recognition in the Phytolacca americana glycosyltransferase PaGT3

Rakesh Maharjan, Yohta Fukuda, Taisuke Nakayama, Toru Nakayama, Hiroki Hamada, Shin-ichi Ozaki, Tsuyoshi Inoue

Acta Crystallographica Section D Structural Biology, 78(3) 379-389, Mar 1, 2022 Peer-reviewed
An Ambidextrous Polyphenol Glycosyltransferase PaGT2 from Phytolacca americana

Rakesh Maharjan, Yohta Fukuda, Naomichi Shimomura, Taisuke Nakayama, Yuta Okimoto, Koki Kawakami, Toru Nakayama, Hiroki Hamada, Tsuyoshi Inoue, Shin Ichi Ozaki

Biochemistry, 59(27) 2551-2561, Jul 14, 2020 Peer-reviewed
Crown-ether-mediated crystal structures of the glycosyltransferase PaGT3 from Phytolacca americana

Rakesh Maharjan, Yohta Fukuda, Taisuke Nakayama, Toru Nakayama, Hiroki Hamada, Shin Ichi Ozaki, Tsuyoshi Inoue

Acta Crystallographica Section D: Structural Biology, 76 521-530, Jun 1, 2020 Peer-reviewed
Synthesis of glycosides of resveratrol, pinostilbene, and piceatannol by bioconversion with Phytolacca americana

Kei Shimoda, Naoji Kubota, Daisuke Uesugi, Yuya Fujitaka, Shouta Doi, Hiroki Hamada, Atsuhito Kuboki, Yuya Kiriake, Takafumi Iwaki, Shin-ichi Ozaki

Natural Product Communications, 14(8) 1-3, Aug, 2019 Peer-reviewed
Application of Racemization Process to Dynamic Resolution of (RS)-Phenylephrine to (R)-Phenylephrine β-D-Glucoside by Nicotiana tabacum Glucosyltransferase

Fujitaka, Y, Uesugi, D, Hamada, H, Hamada, H, Shimoda, K, Yanagi, M, Inoue, M, Ozaki, S

Natural Product Communications, 13 1465-1466, 2018 Peer-reviewed
Application of racemization process to dynamic resolution of (RS)-phenylephrine to (R)-phenylephrine β-D-glucoside by nicotiana tabacum glucosyltransferase

Yuya Fujitaka, Daisuke Uesugi, Hatsuyuki Hamada, Hiroki Hamada, Kei Shimoda, Masayoshi Yanagi, Manami Inoue, Shin Ichi Ozaki

Natural Product Communications, 13 1465-1466, Jan 1, 2018
HmuS from Yersinia pseudotuberculosis is a non-canonical heme-degrading enzyme to acquire iron from heme.

Masato Onzuka, Yukari Sekine, Takeshi Uchida, Koichiro Ishimori, Shin-Ichi Ozaki

Biochimica et biophysica acta. General subjects, 1861(7) 1870-1878, Jul, 2017 Peer-reviewed
Synthesis, oxygen radical absorbance capacity, and tyrosinase inhibitory activity of glycosides of resveratrol, pterostilbene, and pinostilbene

Daisuke Uesugi, Hiroki Hamada, Kei Shimoda, Naoji Kubota, Shin-ichi Ozaki, Naoki Nagatani

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 81(2) 226-230, Feb, 2017 Peer-reviewed
The crystal structure of heme acquisition system A from Yersinia pseudotuberculosis (HasA(ypt)): Roles of the axial ligand Tyr75 and two distal arginines in heme binding

Masahiro Kanadani, Takehiro Sato, Tomoya Hino, Shingo Nagano, Shin-ichi Ozaki

JOURNAL OF INORGANIC BIOCHEMISTRY, 151 26-33, Oct, 2015 Peer-reviewed
Enzymatic Synthesis of Quercetin Monoglucopyranoside and Maltooligosaccharides

Ryo Yasukawa, Natsumi Moriwaki, Daisuke Uesugi, Fuya Kaneko, Hiroki Hamada, Shin-ichi Ozaki

NATURAL PRODUCT COMMUNICATIONS, 10(6) 949-950, Jun, 2015 Peer-reviewed
Spectroscopic studies on HasA from Yersinia pseudotuberculosis.

Shin-Ichi Ozaki, Takehiro Sato, Yukari Sekine, Catharina T Migita, Takeshi Uchida, Koichiro Ishimori

Journal of inorganic biochemistry, 138 31-38, Sep, 2014 Peer-reviewed
Synthesis of glycosides of resveratrol, pterostilbene, and piceatannol, and their anti-oxidant, anti-allergic, and neuroprotective activities

Daisuke Sato, Nobuyoshi Shimizu, Yoshiko Shimizu, Masaaki Akagi, Yuki Eshita, Shin-ichi Ozaki, Nobuyoshi Nakajima, Kohji Ishihara, Noriyoshi Masuoka, Hiroki Hamada …

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 78(7) 1123-1128, Jul, 2014 Peer-reviewed
Inhibition of Heme Uptake in Pseudomonas aeruginosa by its Hemophore (HasA(p)) Bound to Synthetic Metal Complexes

Chikako Shirataki, Osami Shoji, Mitsuyoshi Terada, Shin-ichi Ozaki, Hiroshi Sugimoto, Yoshitsugu Shiro, Yoshihito Watanabe

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 53(11) 2862-2866, Mar, 2014
Glucosylation of hydroxyflavones by glucosyltransferases from Phytolacca americana

Tomoya Iwakiri, Shogo Mase, Tomonori Murakami, Masahiro Matsumoto, Hiroki Hamada, Toru Nakayama, Shin-ichi Ozaki

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 90 61-65, Jun, 2013 Peer-reviewed
3P005 Crystal structure of a hemophore hasA secreted by Yersinia pseudotuberclosis shows a novel heme binding mode(01A. Protein: Structure,Poster)

Kanadani Masahiro, Muroki Toshiki, Ishimaru Yukie, Wada Saki, Sato Takehiro, Ozaki Shin-ichi, Hino Tomoya, Nagano Shingo

Seibutsu Butsuri, 53(1) S212, 2013
Synthesis of 3,5,3 ',4 '-Tetrahydroxy-trans-stilbene-4 '-O-beta-D-glucopyranoside by Glucosyltransferases from Phytolacca americana

Tomoya Iwakiri, Hiroya Imai, Hiroki Hamada, Toru Nakayama, Shin-ichi Ozaki

NATURAL PRODUCT COMMUNICATIONS, 8(1) 119-120, 2013 Peer-reviewed
P-15 The synthesis of saponines using glucose transferase derived from plant cells and study of it's functional activity(Poster Presentation)

Hamada Hiroki, Matsumoto Masahiro, Takemoto Mai, Shimoda Kei, Ozaki Shinichi, Nakayama Toru

Symposium on the Chemistry of Natural Products, symposium papers, (54) 309-314, Sep 1, 2012
Regioselective glucosidation of trans-resveratrol in Escherichia coli expressing glucosyltransferase from Phytolacca americana

Shin-ichi Ozaki, Hiroya Imai, Tomoya Iwakiri, Takehiro Sato, Kei Shimoda, Toru Nakayama, Hiroki Hamada

BIOTECHNOLOGY LETTERS, 34(3) 475-481, Mar, 2012
P-40 The synthesis of the high functional saponines using glucose transferase derived from plants cells(Poster Presentation)

Hamada Hiroki, Imai Hiroya, Kitagawa Megumi, Shimoda Kei, Ozaki Shinichi, Nakayama Toru

Symposium on the Chemistry of Natural Products, symposium papers, (53) 601-606, Sep 2, 2011

Misc.

The enzymatic study of hydroxylation, methylation and glycosylation of Phytolacca americana

濱田博喜, 上杉大介, 藤高侑也, 下田恵, 小崎紳一, 和氣駿之, 中山亨, 福田庸太, 井上豪

天然有機化合物討論会講演要旨集(Web), 60th, 2018
Formation and reaction of compound I in myoglobin

T Matsui, SI Ozaki, Y Watanabe

JOURNAL OF INORGANIC BIOCHEMISTRY, 74(1-4) 225-225, Apr, 1999
Reaction mechanisms of N-demethylation and sulfoxidation catalyzed by heme enzymes

Y Goto, T Matsui, SI Ozaki, Y Watanabe, S Fukuzumi, JP Dinnocenzo, JP Jones

JOURNAL OF INORGANIC BIOCHEMISTRY, 74(1-4) 146-146, Apr, 1999
Stereoselective oxygenation by myoglobin mutants.

S Ozaki, T Matsui, Y Watanabe

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 213 195-BIOT, Apr, 1997
CATALYTIC INTERMEDIATES OF POLYETHYLENE GLYCOLATED HORSERADISH PEROXIDASE IN BENZENE

OZAKI Shin-ichi, INADA Yuji, WATANABE Yoshihito

45 S68, Dec 1, 1996

Teaching Experience

Research Projects

マラリア原虫のアルテミシニン耐性においてフェレドキシンの変異が果たす役割の解明

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

木股洋子, 齊藤貴士, 小崎紳一
病原性細菌が嫌気的にヘムを開環分解して生存に必須の鉄を取り出す機構の解明

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

小崎紳一, 樋口恒彦, 木股洋子, 永野真吾
Heme transport and degradation by enteric pathogens

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Shin-ichi Ozaki
Mechanism of heme transfer and metabolism by pathogenic bacteria

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Shin-ichi Ozaki, Azakami Hiroyuki, Nagano Shingo, Migita Catharina T
Heme oxygenase strategy for circumventing environmental changes_fine tuning of activity

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

MIGITA Taiko, OZAKI Shinichi, MIGITA Kouto, SATO Michihiko, ZHANG Xuhong
Characterization of heme transport proteins from pathogenic bacteria

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2009 - 2011

OZAKI Shinichi, MIGITA Taiko
Regulation of Protein Functions by Hume and CBS Domain

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2005 - 2007

OZAKI Shin-ichi, MIGITA Taiko
ヘムによる酵素機能のスイッチング

科学研究費助成事業, 若手研究(B), 日本学術振興会, 2001 - 2002

小崎紳一
Molecular Design of Metalloproteins

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Priority Areas, Japan Society for the Promotion of Science, 1999 - 2002

WATANABE Yoshihito, OZAKI Shin-ichi, OGO Seiji, UENO Takafumi
モノオキシゲナーゼの構築-P450酸化活性種の蛋白モデルによる検証

科学研究費助成事業, 基盤研究(B), 日本学術振興会, 1999 - 2001

渡辺芳人, 上野隆史, 小江誠司, 小崎紳一
Rational Design of a Catalytic Site in Myoglobin

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1998 - 2000

OZAKI Shin-ichi, WATANABE Yoshihito
抗エイズ剤、リボソーム阻害酵素(GAP31)の構造と機能の考察

科学研究費助成事業, 奨励研究(A), 日本学術振興会, 1996 - 1996

小崎紳一
CHARACTERIZATION OF UNSTABLE INTERMEDIATES OF HEME ENZYMES BY UTILIZING ENZYMES AND THEIR HYBRIDES

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 1995 - 1996

WATANABE Yoshihito, SHIMADA Hideo, OZAKI Shin-ichi

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Research Areas

Research History

Papers

Misc.

Teaching Experience

Research Projects

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