論文

査読有り 本文へのリンクあり 国際誌
2020年12月

A detection method for latent circadian rhythm sleep-wake disorder

EBioMedicine
  • Makoto Akashi
  • ,
  • Reimi Sogawa
  • ,
  • Ritsuko Matsumura
  • ,
  • Atsuhiro Nishida
  • ,
  • Rino Nakamura
  • ,
  • Isao T. Tokuda
  • ,
  • Koichi Node

62
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.ebiom.2020.103080

© 2020 The Author(s) Background: Individuals with typical circadian rhythm sleep-wake disorders (CRSWDs) have a habitual sleep timing that is desynchronized from social time schedules. However, it is possible to willfully force synchronisation against circadian-driven sleepiness, which causes other sleep problems. This pathology is distinguishable from typical CRSWDs and is referred to here as latent CRSWD (LCRSWD). Conventional diagnostic methods for typical CRSWDs are insufficient for detecting LCRSWD because sufferers have an apparently normal habitual sleep timing. Methods: We first evaluated the reliability of circadian phase estimation based on clock gene expression using hair follicles collected at three time points without sleep interruption. Next, to identify detection criteria for LCRSWD, we compared circadian and sleep parameters according to estimated circadian phases, at the group and individual level, between subjects with low and high Pittsburgh Sleep Quality Index (PSQI) scores. To validate the reliability of identified detection criteria, we investigated whether the same subjects could be reproducibly identified at a later date and whether circadian amelioration resulted in sleep improvement. Findings: We successfully validated the reliability of circadian phase estimation at three time points and identified potential detection criteria for individuals with LCRSWD attributed to delayed circadian-driven sleepiness. In particular, a criterion based on the interval between the times of the estimated circadian phase of clock gene expression and getting out of bed on work or school days was promising. We also successfully confirmed the reproducibility of candidate screening and sleep improvement by circadian amelioration, supporting the reliability of the detection criteria. Interpretation: Although several limitations remain, our present study demonstrates a promising prototype of a detection method for LCRSWD attributed to delayed circadian-driven sleepiness. More extensive trials are needed to further validate this method. Funding: This study was supported mainly by JSPS, Japan.

リンク情報
DOI
https://doi.org/10.1016/j.ebiom.2020.103080
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33166792
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85095415524&origin=inward 本文へのリンクあり
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85095415524&origin=inward
ID情報
  • DOI : 10.1016/j.ebiom.2020.103080
  • eISSN : 2352-3964
  • PubMed ID : 33166792
  • SCOPUS ID : 85095415524

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