Motoki Murata

Profile Information

Affiliation: Institute for Promotion of Science and Technology, Advanced Research Support Center, Ehime University
: 学術共同研究者, 九州大学大学院農学研究院生物機能科学部門

Degree: 農学

J-GLOBAL ID: 201801015335358622
researchmap Member ID: 7000022176

Research Interests

Research Areas

Research History

Apr, 2019 - Present

Kyushu University
Jan, 2018 - Present

Institute for Promotion of Science and Technology, Advanced Research Support Center, Ehime University
Apr, 2017 - Dec, 2017

学術研究員, 農学研究院, 九州大学大学院
Apr, 2014 - Mar, 2017

博士課程, 生物資源環境科学府生物産業創成専攻, 九州大学大学院
Apr, 2012 - Mar, 2014

修士課程, 生物資源環境科学府生命機能科学専攻, 九州大学大学院

Papers

(-)‑Epigallocatechin‑3‑O‑gallate upregulates the expression levels of miR‑6757‑3p, a suppressor of fibrosis‑related gene expression, in extracellular vesicles derived from human umbilical vein endothelial cells.

Motoki Murata, Yuki Marugame, Mai Morozumi, Kyosuke Murata, Motofumi Kumazoe, Yoshinori Fujimura, Hirofumi Tachibana

Biomedical reports, 18(3) 19-19, Mar, 2023
Quercetin up-regulates the expression of tumor-suppressive microRNAs in human cervical cancer.

Motoki Murata, Satomi Komatsu, Emi Miyamoto, Chihiro Oka, Ichian Lin, Motofumi Kumazoe, Shuya Yamashita, Yoshinori Fujimura, Hirofumi Tachibana

Bioscience of microbiota, food and health, 42(1) 87-93, 2023
Circulating miRNA profiles in mice plasma following flavonoid intake

Motoki Murata, Yuki Marugame, Shuhei Yamada, Ichian Lin, Shuya Yamashita, Yoshinori Fujimura, Hirofumi Tachibana

Molecular Biology Reports, 49(11) 10399-10407, Sep 13, 2022 Peer-reviewedLead author
Japanese soup stocks (katsuo-dashi and kombu-dashi) modulate food factor sensing-related gene expression in mice

Motoki Murata, Kai Nakayama, Ryo Kitamura, Megumi Goto, Mai Morozumi, Takanori Yoshimoto, Yuki Marugame, Ren Yoshitomi, Shuya Yamashita, Yoshinori Fujimura, Hirofumi Tachibana

International Journal of Gastronomy and Food Science, 29 100573-100573, Sep, 2022 Peer-reviewedLead author
Soy isoflavone metabolite equol inhibits cancer cell proliferation in a PAP associated domain containing 5-dependent and an estrogen receptor-independent manner.

Shuya Yamashita, Ichian Lin, Chihiro Oka, Motofumi Kumazoe, Satomi Komatsu, Motoki Murata, Shoko Kamachi, Hirofumi Tachibana

The Journal of nutritional biochemistry, 100 108910-108910, Nov 18, 2021 Peer-reviewed
EGCG down-regulates MuRF1 expression through 67-kDa laminin receptor and the receptor signaling is amplified by eriodictyol.

Motoki Murata, Yuki Shimizu, Yuki Marugame, Ayaka Nezu, Konatsu Fujino, Shuhei Yamada, Motofumi Kumazoe, Yoshinori Fujimura, Hirofumi Tachibana

Journal of natural medicines, 74(4) 673-679, May 29, 2020 Peer-reviewedLead author
Cancer cell selective probe by mimicking EGCG.

Motofumi Kumazoe, Shun Hiroi, Yousuke Tanimoto, Jyunichi Miyakawa, Maasa Yamanouchi, Yumi Suemasu, Ren Yoshitomi, Motoki Murata, Yoshinori Fujimura, Takashi Takahashi, Hiroshi Tanaka, Hirofumi Tachibana

Biochemical and biophysical research communications, 525(4) 974-981, May 14, 2020 Peer-reviewed
Long-term dietary supplementation with the green tea cultivar Sunrouge prevents age-related cognitive decline in the senescence-accelerated mouse Prone8.

Masafumi Wasai, Haruna Nonaka, Motoki Murata, Ryo Kitamura, Yuka Sato, Hirofumi Tachibana

Bioscience, biotechnology, and biochemistry, 83(2) 339-347, Feb, 2019 Peer-reviewed
Postprandial glycaemia-lowering effect of a green tea cultivar Sunrouge and cultivar-specific metabolic profiling for determining bioactivity-related ingredients.

Masafumi Wasai, Yoshinori Fujimura, Haruna Nonaka, Ryo Kitamura, Motoki Murata, Hirofumi Tachibana

Scientific reports, 8(1) 16041-16041, Oct 30, 2018 Peer-reviewed
Saturated fatty acid attenuates anti-obesity effect of green tea.

Shuya Yamashita, Asami Hirashima, I-Chian Lin, Jaehoon Bae, Kanami Nakahara, Motoki Murata, Shuhei Yamada, Motofumi Kumazoe, Ren Yoshitomi, Mai Kadomatsu, Yuka Sato, Ayaka Nezu, Ai Hikida, Konatsu Fujino, Kyosuke Murata, Mari Maeda-Yamamoto, Hirofumi Tachibana

Scientific reports, 8(1) 10023-10023, Jul, 2018 Peer-reviewed
FOXO3 is essential for CD44 expression in pancreatic cancer cells

M. Kumazoe, M. Takai, J. Bae, S. Hiroi, Y. Huang, K. Takamatsu, Y. Won, M. Yamashita, S. Hidaka, S. Yamashita, S. Yamada, M. Murata, S. Tsukamoto, H. Tachibana

ONCOGENE, 36(19) 2643-2654, May, 2017 Peer-reviewed
Green Tea Polyphenol Epigallocatechin-3-gallate Suppresses Toll-like Receptor 4 Expression via Up-regulation of E3 Ubiquitin-protein Ligase RNF216

Motofumi Kumazoe, Yuki Nakamura, Mai Yamashita, Takashi Suzuki, Kanako Takamatsu, Yuhui Huang, Jaehoon Bae, Shuya Yamashita, Motoki Murata, Shuhei Yamada, Yuki Shinoda, Wataru Yamaguchi, Yui Toyoda, Hirofumi Tachibana

JOURNAL OF BIOLOGICAL CHEMISTRY, 292(10) 4077-4088, Mar, 2017 Peer-reviewed
Delphinidin Prevents Muscle Atrophy and Upregulates miR-23a Expression

Motoki Murata, Haruna Nonaka, Satomi Komatsu, Megumi Goto, Mai Morozumi, Shuhei Yamada, I-Chian Lin, Shuya Yamashita, Hirofumi Tachibana

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 65(1) 45-50, Jan, 2017 Peer-reviewedLead author
Delphinidin prevents disuse muscle atrophy and reduces stress-related gene expression

Motoki Murata, Reia Kosaka, Kana Kurihara, Shuya Yamashita, Hirofumi Tachibana

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 80(8) 1636-1640, Aug, 2016 Peer-reviewedLead author
Equol suppresses inflammatory response and bone erosion due to rheumatoid arthritis in mice

I-Chian Lin, Shuya Yamashita, Motoki Murata, Motofumi Kumazoe, Hirofumi Tachibana

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 32 101-106, Jun, 2016 Peer-reviewed
gamma-Tocotrienol upregulates aryl hydrocarbon receptor expression and enhances the anticancer effect of baicalein

Shuya Yamashita, Kiwako Baba, Akiko Makio, Motofumi Kumazoe, Yuhui Huang, I-Chian Lin, Jaehoon Bae, Motoki Murata, Shuhei Yamada, Hirofumi Tachibana

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 473(4) 801-807, May, 2016 Peer-reviewed
Green tea polyphenol epigallocatechin-O-gallate induces cell death by acid sphingomyelinase activation in chronic myeloid leukemia cells

Yuhui Huang, Motofumi Kumazoe, Jaehoon Bae, Shuhei Yamada, Miica Takai, Shiori Hidaka, Shuya Yamashita, Yoonhee Kim, Yeongseon Won, Motoki Murata, Shuntaro Tsukamoto, Hirofumi Tachibana

ONCOLOGY REPORTS, 34(3) 1162-1168, Sep, 2015 Peer-reviewed
1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose increases a population of T regulatory cells and inhibits IgE production in ovalbumin-sensitized mice

Yoon Hee Kim, Xue Yang, Shuya Yamashita, Motofumi Kumazoe, Yuhui Huang, Kanami Nakahara, Yeong Seon Won, Motoki Murata, I-Chian Lin, Hirofumi Tachibana

INTERNATIONAL IMMUNOPHARMACOLOGY, 26(1) 30-36, May, 2015 Peer-reviewed
Metabolic Profiling-based Data-mining for an Effective Chemical Combination to Induce Apoptosis of Cancer Cells

Motofumi Kumazoe, Yoshinori Fujimura, Shiori Hidaka, Yoonhee Kim, Kanako Murayama, Mika Takai, Yuhui Huang, Shuya Yamashita, Motoki Murata, Daisuke Miura, Hiroyuki Wariishi, Mari Maeda-Yamamoto, Hirofumi Tachibana

Scientific Reports, 5 9474, 2015 Peer-reviewed
67-kDa Laminin Receptor-dependent Protein Phosphatase 2A (PP2A) Activation Elicits Melanoma-specific Antitumor Activity Overcoming Drug Resistance

Shuntaro Tsukamoto, Yuhui Huang, Daisuke Umeda, Shuhei Yamada, Shuya Yamashita, Motofumi Kumazoe, Yoonhee Kim, Motoki Murata, Koji Yamada, Hirofumi Tachibana

JOURNAL OF BIOLOGICAL CHEMISTRY, 289(47) 32671-32681, Nov, 2014 Peer-reviewed

Misc.

デルフィニジンの骨格筋線維型変換作用

高橋里奈, 村田希, 村田希, 丸亀裕貴, 藤村由紀, 立花宏文

日本栄養・食糧学会大会講演要旨集, 76th, 2022
The effects of green tea polyphenol EGCG are mediated by extracellular vesicles derived from hepatocytes

宮脇早希, 村田希, 村田希, 丸亀裕貴, 藤村由紀, 立花宏文

日本農芸化学会大会講演要旨集(Web), 2022, 2022
Delphinidin exerts anti-inflammatory effects through extracellular vesicles

竹内陽奈子, 村田希, 村田希, 丸亀裕貴, 藤村由紀, 立花宏文

日本農芸化学会大会講演要旨集(Web), 2022, 2022
腸管上皮細胞由来の細胞外小胞におけるDelphinidinの筋萎縮予防miR-23aの発現上昇作用

丸亀裕貴, 村田希, 村田希, 後藤萌, 藤村由紀, 立花宏文

日本栄養・食糧学会大会講演要旨集, 74th, 2020
緑茶カテキンEGCGの筋萎縮抑制作用メカニズム解明ならびにエリオジクチオールによる増強

村田希, 村田希, 丸亀裕貴, 清水友貴, 熊添基文, 藤村由紀, 立花宏文

日本栄養・食糧学会大会講演要旨集, 74th, 2020
IL-4 receptor alpha in non-lipid rafts is the target molecule of strictinin in inhibiting STAT6 activation

Yoon Hee Kim, Yu Ninomiya, Shuya Yamashita, Motofumi Kumazoe, Yuhui Huang, Kanami Nakahara, Yeong Seon Won, Motoki Murata, Yoshinori Fujimura, Koji Yamada, Hirofumi Tachibana

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 450(1) 824-830, Jul, 2014

Professional Memberships

Research Projects

食品因子デルフィニジンによる運動機能改善効果

科学研究費助成事業若手研究, 日本学術振興会, Apr, 2022 - Mar, 2025

村田希
食機能実行分子とその機能的相互作用の統合的理解

科学研究費助成事業基盤研究(S), 日本学術振興会, Aug, 2020 - Mar, 2025

立花宏文, 藤村由紀, 村田希, 山崎正夫, 西平順
食品因子デルフィニジンによるマイクロRNA発現調節作用機構の解明

科学研究費助成事業若手研究, 日本学術振興会, Apr, 2019 - Mar, 2022

村田希
Elucidation of molecular mechanism for Delphinidin by using a genetic screen

Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity start-up, Japan Society for the Promotion of Science, Aug, 2017 - Mar, 2019

Murata Motoki, Tachibana Hirofumi
Research on food interaction through food factor-sensing

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2017

Yamashita Shuya, TACHIBANA Hirofumi, KUMAZOE Motofumi, NAKAHARA Kanami, WON Yeong Seon, MURATA Motoki, LIN I-Chian

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Research Interests

Research Areas

Research History

Papers

Misc.

Professional Memberships

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