MISC

2014年7月

IL-4 receptor α in non-lipid rafts is the target molecule of strictinin in inhibiting STAT6 activation

Biochemical and Biophysical Research Communications
  • Yoon Hee Kim
  • ,
  • Yu Ninomiya
  • ,
  • Shuya Yamashita
  • ,
  • Motofumi Kumazoe
  • ,
  • Yuhui Huang
  • ,
  • Kanami Nakahara
  • ,
  • Yeong Seon Won
  • ,
  • Motoki Murata
  • ,
  • Yoshinori Fujimura
  • ,
  • Koji Yamada
  • ,
  • Hirofumi Tachibana
  • ,
  • Hirofumi Tachibana
  • ,
  • Hirofumi Tachibana

450
1
開始ページ
824
終了ページ
830
記述言語
英語
掲載種別
DOI
10.1016/j.bbrc.2014.06.069

Strictinin has been shown to suppress interleukin (IL)-4-induced signal transducer and activator of transcription (STAT)-6 phosphorylation, which is a critical event for IgE class switching. However, it is unclear how strictinin inhibits STAT6 activation. Strictinin inhibited STAT6 phosphorylation by suppressing IL-4 receptor α (IL-4Rα) activation. Strictinin was bound to the cell surface and only localized in non-lipid raft fraction of the cells where IL-4Rα was also located. In addition, strictinin directly bound to IL-4Rα and inhibited binding of IL-4 to IL-4Rα. These results suggest that IL-4Rα locating in non-lipid raft region is a target molecule for strictinin in inhibiting STAT6 activation. © 2014 Elsevier Inc. All rights reserved.

Web of Science ® 被引用回数 : 6

リンク情報
DOI
https://doi.org/10.1016/j.bbrc.2014.06.069
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24960198
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000343641000136&DestApp=WOS_CPL
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84904753186&origin=inward

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