論文

査読有り
2016年8月

Physical association between a novel plasma-membrane structure and centrosome orients cell division

ELIFE
  • Takefumi Negishi
  • ,
  • Naoyuki Miyazaki
  • ,
  • Kazuyoshi Murata
  • ,
  • Hitoyoshi Yasuo
  • ,
  • Naoto Ueno

5
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.7554/eLife.16550
出版者・発行元
ELIFE SCIENCES PUBLICATIONS LTD

In the last mitotic division of the epidermal lineage in the ascidian embryo, the cells divide stereotypically along the anterior-posterior axis. During interphase, we found that a unique membrane structure invaginates from the posterior to the centre of the cell, in a microtubule-dependent manner. The invagination projects toward centrioles on the apical side of the nucleus and associates with one of them. Further, a cilium forms on the posterior side of the cell and its basal body remains associated with the invagination. A laser ablation experiment suggests that the invagination is under tensile force and promotes the posterior positioning of the centrosome. Finally, we showed that the orientation of the invaginations is coupled with the polarized dynamics of centrosome movements and the orientation of cell division. Based on these findings, we propose a model whereby this novel membrane structure orchestrates centrosome positioning and thus the orientation of cell division axis.

Web of Science ® 被引用回数 : 11

リンク情報
DOI
https://doi.org/10.7554/eLife.16550
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27502556
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000380929500001&DestApp=WOS_CPL

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