2020年1月
Synthesis of optically active (R)- And (S)-β-arginine from pyroglutamic acid
Heterocycles
- ,
- ,
- ,
- 巻
- 101
- 号
- 1
- 開始ページ
- 165
- 終了ページ
- 176
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3987/COM-19-S(F)6
© 2020 The Japan Institute of Heterocyclic Chemistry – The first synthesis of optically active β-arginine was achieved starting from commercially available pyroglutamic acid. The new synthetic protocol is characterized by the use of nitrile as a carboxylic acid surrogate which could be transformed to the corresponding 2-acyl-1,3-bis(1,1-dimethylethyl)imidodi-carbonic acid ester (active amide) via Pt-catalyzed hydration under the mild conditions. The active amide was converted to β-arginine and Boc-β-Arg-Val-OMe in good yield.
- リンク情報
- ID情報
-
- DOI : 10.3987/COM-19-S(F)6
- ISSN : 0385-5414
- eISSN : 1881-0942
- SCOPUS ID : 85078546837