2018年5月18日
Facile Construction of Tetrahydropyrrolizines by Iron-Catalyzed Double Cyclization of Alkene-Tethered Oxime Esters with 1,2-Disubstituted Alkenes
Organic Letters
- ,
- ,
- ,
- 巻
- 20
- 号
- 10
- 開始ページ
- 3044
- 終了ページ
- 3048
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/acs.orglett.8b01073
- 出版者・発行元
- American Chemical Society
The iron-catalyzed cycloaddition reaction of alkene-tethered oxime esters with 1,2-disubstituted alkenes afforded tetrahydropyrrolizines, the structural motif often seen in bicyclic alkaloids. The reaction proceeds through consecutive cycloaddition reactions. These include, first, intramolecular cyclization, followed by intermolecular cyclization with a 1,2-disubstituted alkene in a regioselective manner where an imine moiety first generated plays a pivotal role.
- ID情報
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- DOI : 10.1021/acs.orglett.8b01073
- ISSN : 1523-7052
- ISSN : 1523-7060
- ORCIDのPut Code : 45002412
- SCOPUS ID : 85047312908