玉川 洋

消化器外科の研究を中心に英文筆頭12編、英文共著42編、邦文筆頭13編、邦文共著68編の論文を発表しています。特にepigeneticsの研究分野では、神奈川県立がんセンターにおいて、主に大腸がんと肝転移巣におけるヒストン修飾の発現を発見し、2013年6月に同分野で横浜市立大学より医学博士の学位を取得しています。

現在は横浜市立大学附属病院で消化器がんに対する鏡視下手術を指導し、臨床データの解析を中心に研究活動を行っています。

 

主な業績

 

1.　Sandwich technique via right ventricle incision to repair postinfarction ventricular septal defect.

Isoda S, Imoto K, Uchida K, Hashiyama N, Yanagi H, Tamagawa H, Takanashi Y.　

J Card Surg. 2004 Mar-Apr;19(2):149-50.

 

2.　Changes in vitamin D after gastrectomy.

Rino Y, Yamamoto Y, Wada N, Yukawa N, Murakami H, Tamagawa H, Yamada T, Ohshima T, Masuda M, Imada T.　

Gastric Cancer. 2007;10(4):228-33. Epub 2007 Dec 25.

 

3.　Relationship between RegIV gene expression to outcomes in colorectal cancer.　

Numata M, Oshima T, Yoshihara K, Watanabe T, Tsuchida K, Tamagawa H, Yamamoto N, Shiozawa M, Morinaga S, Akaike M, Kunisaki C, Rino Y, Tanaka K, Masuda M, Imada T. 

J Surg Oncol. 2011 Aug 1;104(2):205-9. doi: 10.1002/jso.21906. Epub 2011 Mar

 

4.　Immunohistochemical Analysis of Human Equilibrative Nucleoside Transporter-1 (hENT1) Predicts Survival in Resected Pancreatic Cancer Patients Treated with Adjuvant Gemcitabine Monotherapy. 

Morinaga S, Nakamura Y, Watanabe T, Mikayama H, Tamagawa H, Yamamoto N, Shiozawa M, Akaike M, Ohkawa S, Kameda Y, Miyagi Y. 

Ann Surg Oncol. 2011 Sep 13.

 

5.  A case of adenomyomatous hyperplasia of the extrahepatic bile duct.

Numata M, Morinaga S, Watanabe T, Tamagawa H, Yamamoto N, Shiozawa M, Kameda Y, Ohkawa S, Rino Y, Akaike M, Masuda M. 

Case Rep Gastroenterol. 2011 May;5(2):457-62.

 

6.　☆The Expression of the Phosphatase Regenerating Liver 3 Gene is Associated with Outcome in Patients with Colorectal Cancer. 

Tamagawa H, Oshima T, Yoshihara K, Watanabe T, Numata M, Yamamoto N, Tuschida K, Shiozawa M, Morinaga S, Akaike M, Masuda M, Imada T.

Hepatogastroenterology. 2012 Mar 20;59(119).

 

7.　〇☆The global histone modification pattern correlates with overall survival in metachronous liver metastasis of colorectal cancer. 

Tamagawa H, Oshima T, Shiozawa M, Morinaga S, Nakamura Y, Yoshihara M, Sakuma Y, Kameda Y, Akaike M, Masuda M, Imada T, Miyagi Y.

Oncol Rep. 2012 Mar;27(3):637-42.

 

8.　☆Comparison of the chemosensitivity of the primary lesion and a pancreatic metastasis of colon cancer: a case report. 

Tamagawa H, Miyagi Y, Numata M, Yamamoto N, Shiozawa M, Morinaga S, Sekiyama A, Sekiguchi H, Sakuma Y, Kameda Y, Akaike M, Masuda M, Imada T.

Anticancer Res. 2012 Apr;32(4):1457-61.

 

9.　◎☆Global histone modification of H3K27 correlates with the outcomes in patients with metachronous liver metastasis of colorectal cancer.

Tamagawa H, Oshima T, Numata M, Yamamoto N, Shiozawa M, Morinaga S, Nakamura Y, Yoshihara M, Sakuma Y, Kameda Y, Akaike M, Yukawa N, Rino Y, Masuda M, Miyagi Y.

Eur J Surg Oncol. 2013 Jun;39(6):655-61.

 

10.　Using NU-KNIT® for hemostasis around recurrent laryngeal nerve during transthoracic esophagectomy with lymphadenectomy for esophageal cancer.

Rino Y, Yukawa N, Sato T, Yamamoto N, Tamagawa H, Hasegawa S, Oshima T, Yoshikawa T, Masuda M, Imada T.　

BMC Res Notes. 2014 Mar 6;7:127.

 

11.　Visualization of blood supply route to the reconstructed stomach by indocyanine green fluorescence imaging during esophagectomy.

Rino Y, Yukawa N, Sato T, Yamamoto N, Tamagawa H, Hasegawa S, Oshima T, Yoshikawa T, Masuda M, Imada T. 　

BMC Med Imaging. 2014 May 22;14:18.

 

12.　Vitamin E deficiency begins within 6 months after gastrectomy for gastric cancer.

Rino Y, Yukawa N, Sato T, Yamamoto N, Tamagawa H, Hasegawa S, Hayashi T, Atsumi Y, Oshima T, Yoshikawa T, Masuda M, Imada T.　

World J Surg. 2014 Aug;38(8):2065-9.

 

13.　Safety of Laparoscopic Surgery for Colorectal Cancer in Patients with Severe Comorbidities. 

Sawazaki S, Numata M, Morita J, Maezawa Y, Amano S, Aoyama T, Tamagawa H, Sato T, Oshima T, Mushiake H, Yukawa N, Shiozawa M, Rino Y, Masuda M. 

Anticancer Res. 2018 Jun;38(6):3767-3772.

 

14. ☆Preoperative evaluation of skeletal muscle mass in the risk assessment for the short-term outcome of elderly colorectal cancer patients undergoing colectomy.

Tamagawa H, Aoyama T, Iguchi K, Fujikawa H, Sawazaki S, Sato T, Musiake H, Oshima T, Yukawa N, Rino Y, Masuda M.

Mol Clin Oncol. 2018 Jun;8(6):779-784.

 

15. The Lymph Node Ratio Is an Independent Prognostic Factor in Pancreatic Cancer Patients Who Receive Curative Resection Followed by Adjuvant Chemotherapy.

Aoyama T, Yamamoto N, Kamiya M, Murakawa M, Tamagawa H, Sawazaki S, Numata M, Shiozawa M, Kobayashi S, Ueno M, Morimoto M, Yukawa N, Oshima T, Yoshikawa T, Rino Y, Masuda M, Morinaga S. 

Anticancer Res. 2018 Aug;38(8):4877-4882.

 

16.　☆Relationship of the tight junction protein claudin-4 gene to outcomes in patients with colorectal cancer

Hiroshi Tamagawa, Takashi Oshima, Toru Aoyama, Kazue Yoshihara, Masakatsu Numata, Tsutomu Sato, Norio Yukawa, Hiroyuki Mushiake, Manabu Shiozawa, Chikara Kunisaki, Munetaka Masuda, Yasushi Rino

Annals of Cancer Research and Therapy. 2018 Sep;26(2):82-88

 

17.　The Lymph Node Ratio Is an Independent Prognostic Factor in　Pancreatic Cancer Patients Who Receive Curative Resection Followed by Adjuvant Chemotherapy. 

Aoyama T, Yamamoto N, Kamiya M, Murakawa M, Tamagawa H, Sawazaki S, Numata M, Shiozawa M, Kobayashi S, Ueno M, Morimoto M, Yukawa N, Oshima T, Yoshikawa T, Rino Y, Masuda M, Morinaga S.

Anticancer Res. 2018 Aug;38(8):4877-4882　

 

18. A Comparison of the Body Composition Changes Between Laparoscopy-assisted and Open Total Gastrectomy for Gastric Cancer.

Aoyama T, Yoshikawa T, Maezawa Y, Kano K, Hara K, Sato T, Hayashi T, Yamada T, Cho H, Ogata T, Tamagawa H, Yukawa N, Rino Y, Masuda M, Oshima T.

In Vivo. 2018 Nov-Dec;32(6):1513-1518　　

 

19. Comparison of Weight and Body Composition After Gastrectomy Between Elderly and Non-elderly Patients With Gastric Cancer.

Aoyama T, Maezawa Y, Yoshikawa T, Segami K, Kano K, Hayashi T, Yamada T, Numata M, Goda M, Tamagawa H, Sato T, Yukawa N, Rino Y, Masuda M, Ogata T, Cho H, Oshima T.

In Vivo. 2019 Jan-Feb;33(1):221-227　　(10/17)mplications After Gastrectomy on Body Weight and Body Composition Changes in Patients With Gastric Cancer. (II.8)

Aoyama T, Yoshikawa T, Maezawa Y, Segami K, Kano K, Numata M, Yamada T, Tamagawa H, Fujikawa H, Komori K, Hayashi T, Sato T, Yukawa N, Rino Y, Masuda M, Ogata T, Cho H, Oshima T.

Anticancer Res. 2019 Feb;39(2):1073-1078 (8/18)

 

23. The impact of SPARC expression on the survival of pancreatic ductal adenocarcinoma patients after curative resection.

Murakawa M, Aoyama T, Miyagi Y, Kobayashi S, Ueno M, Morimoto M, Numata M, Yamamoto N, Tamagawa H, Yukawa N, Rino Y, Masuda M, Morinaga S.

J Cancer. 2019 Jan 1;10(3):627-633 

 

24. Postoperative Level of C-Reactive Protein Is a Prognosticator After Esophageal Cancer Surgery With Perioperative Steroid Therapy and Enhanced Recovery After Surgery Care.

Kano K, Aoyama T, Maezawa Y, Hayashi T, Yamada T, Tamagawa H, Sato T, Cho H, Yoshikawa T, Rino Y, Masuda M, Oshima T, Ogata T.

In Vivo. 2019 Mar-Apr;33(2):587-594　

 

25.  Influence of Postoperative Pneumonia on Esophageal Cancer Survival and Recurrence. (II.8)

Tamagawa A, Aoyama T, Tamagawa H, Ju M, Komori K, Maezawa Y, Kano K, Kazama K, Murakawa M, Atsumi Y, Sawazaki S, Hara K, Numata M, Sato T, Yukawa N, Masuda M, Rino Y.

Anticancer Res. 2019 May;39(5):2671-2678　

 

26. The postoperative lean body mass loss at one month leads to a poor survival in patients with locally advanced gastric cancer.

Aoyama T, Yoshikawa T, Maezawa Y, Kano K, Numata M, Hara K, Komori K, Yamada T, Hayashi T, Sato T, Tamagawa H, Yukawa N, Rino Y, Masuda M, Ogata T, Cho H, Oshima T.

J Cancer. 2019 May 28;10(11):2450-2456　

 

27. Beppu's Nomogram Score Is an Independent Prognostic Factor for Colorectal Liver Metastasis Receiving Perioperative Chemotherapy and/or Targeted Therapy.

Higuchi A, Aoyama T, Kazama K, Murakawa M, Atsumi Y, Katayama Y, Numata K, Sawazaki S, Numata M, Sato S, Sugano N, Tamagawa H, Mushiake H, Oshima T, Yukawa N, Morinaga S, Rino Y, Masuda M, Shiozawa M.

In Vivo. 2019 Jul-Aug;33(4):1301-1306　

 

28. A seven-step dissection technique for robotic total mesorectal excision of rectal cancer.

Numata M, Sawazaki S, Kazama K, Aoyama T, Tamagawa H, Sato T, Mushiake H, Yukawa N, Shiozawa M, Masuda M, Rino Y.

Tech Coloproctol. 2019 Sep;23(9):913-918　

 

29. Impact of the Age-adjusted Charlson comorbidity index on the short- and long-term outcomes of patients undergoing curative gastrectomy for gastric cancer.

Maezawa Y, Aoyama T, Kano K, Tamagawa H, Numata M, Hara K, Murakawa M, Yamada T, Sato T, Ogata T, Oshima T, Yukawa N, Yoshikawa T, Masuda M, Rino Y.

J Cancer. 2019 Aug 29;10(22):5527-5535　

 

30. Clinical Significance of KIAA1199 as a Novel Target for Gastric Cancer Drug Therapy. 

Oneyama M, Sakamoto N, Oue N, Kimura Y, Hiroshima Y, Hashimoto I, Hara K, Maezawa Y, Kano K, Aoyama T, Fujikawa H, Yamada T, Tamagawa H, Yamamoto N, Ogata T, Cho H, Ito H, Yukawa N, Shiozawa M, Yoshikawa T, Morinaga S, Rino Y, Masuda M, Miyagi Y, Yasui W, Oshima T.

Anticancer Res. 2019 Dec;39(12):6567-6573　

 

31. The Oral Health Assessment Tool score is an independent risk factor for postoperative pneumonia after esophagectomy for esophageal cancer

Ayako Tamagawa, Toru Aoyama, Hiroshi Tamagawa, Kentaro Hara, Yosuke Atsumi, Kazuki Kano, Masaaki Murakawa, Keisuke Kazama, Yukio Maezawa, Masakatsu Numata, Norio Yukawa, Munetaka Masuda, Yasushi Rino

Annals of Cancer Research and Therapy. 2019 Dec;27(2):31-36　

 

32. ☆Therapeutic results of Denver Percutaneous Peritoneo-venous Shunt in Cancer patients with Malignant Ascites

H. Tamagawa, T. Aoyama, H. Inoue, H. Fujikawa, S. Sawazaki, M. Numata,

T. Sato, T. Oshima, N. Yukawa, M. Morimoto, M. Ueno, Y. Rino, M. Masuda

J Cancer Res Ther.2019 Des;4, IP:163.58.150.124　

 

33. The Short- and Long-term Outcomes of Esophagectomy for Esophageal Cancer in Patients Older than 75 Years. 

Aoyama T, Hara K, Kazama K, Atsumi Y, Tamagawa H, Tamagawa A, Machida D, Komori K, Maezawa Y, Kano K, Hashimoto I, Oshima T, Murakawa M, Numata M, Yukawa N, Masuda M, Rino Y

Anticancer Res. 2020 Feb;40(2):1087-1093 

 

34. Clinical Influence of Anastomotic Leakage on Esophageal Cancer Survival and Recurrence. 

Aoyama T, Kazama K, Atsumi Y, Tamagawa H, Tamagawa A, Komori K, Machida D, Maezawa Y, Kano K, Hara K, Murakawa M, Numata M, Oshima T, Yukawa N, Masuda M, Rino Y

Anticancer Res. 2020 Jan;40(1):443-449

 

35. ☆The Impact of Intraoperative Blood Loss on the Long-term Prognosis after Curative Resection for Borrmann Type IV Gastric Cancer: A Retrospective Multicenter Study. 

Tamagawa H, Aoyama T, Kano K, Numata M, Atsumi Y, Hara K, Kazama K, Koumori K, Murakawa M, Hashimoto I, Maezawa Y, Yamada T, Yukawa N, Yoshikawa T, Masuda M, Oshima T, Rino Y.

Anticancer Res. 2020 Jan;40(1):405-412 

 

36. Impact of the ESM-1 Gene Expression on Outcomes in Stage II/III Gastric Cancer Patients Who Received Adjuvant S-1 Chemotherapy.

Kano K, Sakamaki K, Oue N, Kimura Y, Hashimoto I, Hara K, Maezawa Y, Aoyama T, Fujikawa H, Hiroshima Y, Yamada T, Tamagawa H, Yamamoto N, Ogata T, Cho H, Ito H, Shiozawa M, Yukawa N, Yoshikawa T, Morinaga S, Rino Y, Yasui W, Masuda M, Miyagi Y, Oshima T 

In Vivo. 2020 Jan-Feb;34(1):461-467

 

37. Clinical Implication of Pre-Operative C-reactive Protein-Albumin Ratio as a Prognostic Factor of Patients with Pancreatic Ductal Adenocarcinoma: A Single-institutional Retrospective Study.

Murakawa M, Yamamoto N, Kamioka Y, Kamiya M, Kobayashi S, Ueno M, Morimoto M, Atsumi Y, Aoyama T, Tamagawa H, Yukawa N, Rino Y, Masuda M, Morinaga S

In Vivo. 2020 Jan-Feb;34(1):347-353 

 

38. Postoperative D-dimer elevation affects tumor recurrence and the long-term survival in gastric cancer patients who undergo gastrectomy. 

Hara K, Aoyama T, Hayashi T, Nakazono M, Nagasawa S, Shimoda Y, Kumazu Y, Numata M, Yamada T, Tamagawa H, Shiozawa M, Morinaga S, Yukawa N, Rino Y, Masuda M, Ogata T, Oshima T

Int J Clin Oncol. 2019 Dec 21  

 

39. The Prognostic Value of the Perioperative Systemic Inflammation Score for Patients with Advanced Gastric Cancer. 

Hara K, Aoyama T, Yamada T, Nakazono M, Nagasawa S, Shimoda Y, Kumazu Y, Numata M, Hayashi T, Tamagawa H, Shiozawa M, Morinaga S, Yukawa N, Rino Y, Masuda M, Ogata T, Oshima T.　 

Anticancer Res. 2020 Mar;40(3):1503-1512

 

40. Short-term Outcomes Following Robotic-assisted Laparoscopic Surgery for Technically Demanding Rectal Cancer. 

Numata M, Kazama K, Onodera A, Hara K, Atsumi Y, Okamoto H, Aoyama T, Tamagawa H, Godai T, Saeki H, Yukawa N, Shiozawa M, Rino Y, Masuda M.

Anticancer Res. 2020 Apr;40(4):2337-2342

 

41. Postoperative Bleeding After Esophagectomy for Esophageal Cancer in Patients Receiving Antiplatelet and Anticoagulation Treatment. 

Aoyama T, Atsumi Y, Hara K, Kazama K, Tamagawa H, Tamagawa A, Komori K, Maezawa Y, Kano K, Hashimoto I, Oshima T, Murakawa M, Numata M, Yukawa N, Masuda M, Rino Y. 

Anticancer Res. 2020 Apr;40(4):2359-2364.

 

42. ☆Influence of the Preoperative C-Reactive Protein-to-Albumin Ratio on Survival and Recurrence in Patients With Esophageal Cancer. 

Tamagawa H, Aoyama T, Tamagawa A, Komori K, Maezawa Y, Kano K, Murakawa M, Atsumi Y, Hara K, Kazama K, Numata M, Oshima T, Yukawa N, Masuda M, Rino Y.

Anticancer Res. 2020 Apr;40(4):2365-2371.

 

43. ☆The Impact of Intraoperative Blood Loss on the Survival of Patients With Stage II/III Pancreatic Cancer.

Tamagawa H, Aoyama T, Yamamoto N, Kamiya M, Murakawa M, Atsumi Y, Numata M, Kazama K, Hara K, Yukawa N, Rino Y, Masuda M, Morinaga S. 

In Vivo. 2020 May-Jun;34(3):1469-1474

 

44. The Clinical Significance of Lymphovascular Invasion in Gastric Cancer.

Fujikawa H, Koumori K, Watanabe H, Kano K, Shimoda Y, Aoyama T, Yamada T, Hiroshi T, Yamamoto N, Cho H, Shiozawa M, Yoshikawa T, Morinaga S, Rino Y, Masuda M, Ogata T, Oshima T. 

In Vivo. 2020 May-Jun;34(3):1533-1539

 

45. Association Between Lymph Node Ratio and Survival in Patients with Pathological Stage II/III Gastric Cancer. 

Kano K, Yamada T, Yamamoto K, Komori K, Watanabe H, Hara K, Shimoda Y, Maezawa Y, Fujikawa H, Aoyama T, Tamagawa H, Yamamoto N, Cho H, Shiozawa M, Yukawa N, Yoshikawa T, Morinaga S, Rino Y, Masuda M, Ogata T, Oshima T.

Ann Surg Oncol. 2020 May 18. doi: 10.1245/s10434-020-08616-1. Online ahead of print.

 

46. Risk Factors for Postoperative Pneumonia After Esophagectomy for Esophageal Cancer

Ayako Tamagawa, Toru Aoyama, Hiroshi Tamagawa, Miwa Ju, Masakatsu Numata, Norio Yukawa, Munetaka Masuda, Yasushi Rino.

Indian Journal of Surgery. 2020 Jan 27

 

47. The Number of Harvested LNs Is an Independent Prognostic Factor in Lymph Node Metastasis-negative Patients Who Received Curative Esophagectomy.

Aoyama T, Atsumi Y, Kawahara S, Tamagawa H, Tamagawa A, Maezawa Y, Kano K, Murakawa M, Kazama K, Numata M, Oshima T, Yukawa N, Masuda M, Rino Y. 

In Vivo. 2020 Jul-Aug;34(4):2021-2027

 

48. Laparoscopic vs. Open Surgery for Stage II/III Colon Cancer Patients With Body Mass Index >25 kg/m2.

Kazama K, Numata M, Aoyama T, Onodeara A, Hara K, Atsumi Y, Tamagawa H, Godai T, Saeki H, Saugusa Y, Okamoto H, Shiozawa M, Oshima T, Yukawa N, Masuda M, Rino Y.

In Vivo. 2020 Jul-Aug;34(4):2079-2085

 

49. The Lymph Node Ratio Is an Independent Prognostic Factor in Esophageal Cancer Patients Who Receive Curative Surgery.

Yukawa N, Aoyama T, Tamagawa H, Tamagawa A, Atsumi Y, Kawahara S, Maezawa Y, Kano K, Murakawa M, Kazama K, Numata M, Oshima T, Masuda M, Rino Y. 

In Vivo. 2020 Jul-Aug;34(4):2087-2093

 

50. The clinical effect of Kampo medicine in multimodal treatment for Gastrointestinal Cancer in Japan.

Aoyama T, Tamagawa H. 

J Cancer. 2020 Jul 11;11(18):5390-5394

 

51. The Short- and Long-term Outcomes of Gastrectomy in Elderly Patients With Gastric Cancer.

Komori K, Kano K, Aoyama T, Hashimoto I, Hara K, Murakawa M, Atsumi Y, Maezawa Y, Kazama K, Numata M, Tamagawa H, Yukawa N, Oshima T, Masuda M, Rino Y. 

In Vivo. 2020 Sep-Oct;34(5):2697-2703

 

52. The Clinical Impact of the Age-adjusted Charlson Comorbidity Index on Esophageal Cancer Patients Who Receive Curative Treatment.

Aoyama T, Atsumi Y, Kawahara S, Tamagawa H, Tamagawa A, Ozawa Y, Maezawa Y, Kano K, Murakawa M, Kazama K, Segami K, Hara K, Numata M, Oshima T, Yukawa N, Masuda M, Rino Y. (4/17)

In Vivo. 2020 Sep-Oct;34(5):2783-2790. 

 

53. ☆ A Comparison of Open and Laparoscopic-assisted Colectomy for Obstructive Colon Cancer.

Tamagawa H, Aoyama T, Numata M, Kazama K, Maezawa Y, Atsumi Y, Hara K, Kawahara S, Kano K, Yukawa N, Saeki H, Godai T, Rino Y, Masuda M. (1/14)

In Vivo. 2020 Sep-Oct;34(5):2797-2801. 

 

54. ☆ The Comparison of Outcomes between Video-assisted Thoracscopic and Open Surgery for Esophageal Cancer

Hiroshi Tamagawa, Masakatsu Numata, Toru Aoyama, Ayako Tamagawa, Keisuke Komori, Yukio Maezawa, Kazuki Kano, Keisuke Kazama, Masaaki Murakawa, Yosuke Atsumi, Kentaro Hara , Shinnosuke Kawahara , Takanobu Yamada , Takashi Ogata , Takashi Ohshima , Norio Yukawa, Munetaka Masuda, Yasushi Rino

Ann. Cancer Res. Ther. 2020 Vol. 28, No. 2,97-101