論文

査読有り
2015年1月

SPECIES DIFFERENCES IN ANDROGEN RECEPTOR EXPRESSION IN THE MEDIAL PREOPTIC AND ANTERIOR HYPOTHALAMIC AREAS OF ADULT MALE AND FEMALE RODENTS

NEUROSCIENCE
  • M. R. Jahan
  • ,
  • K. Kokubu
  • ,
  • Md. N. Islam
  • ,
  • C. Matsuo
  • ,
  • A. Yanai
  • ,
  • G. Wroblewski
  • ,
  • R. Fujinaga
  • ,
  • K. Shinoda

284
開始ページ
943
終了ページ
961
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.neuroscience.2014.11.003
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

The medial preoptic and anterior hypothalamic areas (MPO/AH) are important androgen targets regulating homeostasis, neuroendocrinology and circadian rhythm as well as instinctive and sociosexual behaviors. Although species differences between rats and mice have been pointed out in terms of morphology and physiology, detailed distributions of androgen receptor (AR) have never been compared between the two rodents. In the present study, AR distribution was examined immunohistochemically in serial sections of the MPO/AH and compared for adult rats and mice. Western blotting and immunohistochemistry clearly demonstrated that AR expression in the brain was stronger in mice than in rats and was stronger in males than in females. In addition, we found (1) an "obliquely elongated calbindin-ir cell island" in mice medial preoptic nucleus (MPN) expressed AR intensely, as well as the sexually dimorphic nucleus in the MPN (SDN-MPN) in rats, strongly supporting a "putative SDN-MPN" previously proposed in mice; (2) AR expression in the suprachiasmatic nucleus (SCN) was much more prominent in mice than in rats and differed in localization between the two species; (3) a mouse-specific AR-ir cell cluster was newly identified as the "tear drop nucleus (TDN)", with male-dominant sexual dimorphism; and (4) two rat-specific AR-ir cell clusters were also newly identified as the "rostral and caudal nebular islands", with male-dominant sexual dimorphism. The present results may provide basic morphological evidence underlying species differences in androgen-modified psychological, physiological and endocrinergic responses. Above all, the findings of the mouse-specific TDN and differing AR expression in the SCN might explain not only species difference in gonadal modification of circadian rhythm, but also distinct structural bases in the context of transduction of SCN oscillation. The current study could also serve as a caution that data on androgen-sensitive functions obtained from one species should not always be directly applied to others among rodents. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

Web of Science ® 被引用回数 : 13

リンク情報
DOI
https://doi.org/10.1016/j.neuroscience.2014.11.003
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25446364
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000346243100084&DestApp=WOS_CPL

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