2015年9月
Independent Association Between Improvement of Nonalcoholic Fatty Liver Disease and Reduced Incidence of Type 2 Diabetes
DIABETES CARE
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- 巻
- 38
- 号
- 9
- 開始ページ
- 1673
- 終了ページ
- 1679
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.2337/dc15-0140
- 出版者・発行元
- AMER DIABETES ASSOC
OBJECTIVE
Only a few studies have evaluated the long-term effects of nonalcoholic fatty liver disease (NAFLD) on type 2 diabetes mellitus (T2DM), and none have examined whether NAFLD improvement reduces T2DM incidence. We investigated the association between NAFLD improvement and T2DM incidence.
RESEARCH DESIGN AND METHODS
Between 2000 and 2012, 4,604 participants who underwent a health check twice with > 10 years between were enrolled. Exclusion criteriawere positive hepatitis B surface antigen, positive hepatitis C antibody, ethanol intake > 20 g/day, and diabetes. The 3,074 eligible participants were divided into an NAFLD group (n = 728) and a non-NAFLD group (n = 2,346) according to ultrasonography-detected fatty liver. The NAFLD group was categorized into an improved group (n = 110) and a sustained NAFLD group (n = 618) based on fatty liver disappearance at the second visit. Incident T2DM odds ratios (ORs) were estimated by logistic regression models adjusted for age, sex, BMI, impaired fasting glucose, family history of diabetes, dyslipidemia, hypertension, and physical exercise.
RESULTS
T2DM occurred in 117 participants (16.1%) in the NAFLD group and 72 (3.1%) in the non-NAFLD group. NAFLD at baseline was associated with T2DM incidence (multivariate OR 2.37 [95% CI 1.60-3.52]). T2DM occurred in 7 participants (6.4%) in the improved group and in 110 (17.8%) in the sustained NAFLD group. NAFLD improvement was associated with reduced T2DM incidence (multivariate OR 0.27 [95% CI 0.12-0.61]).
CONCLUSIONS
NAFLD improvement is associated with T2DM incidence reduction.
Only a few studies have evaluated the long-term effects of nonalcoholic fatty liver disease (NAFLD) on type 2 diabetes mellitus (T2DM), and none have examined whether NAFLD improvement reduces T2DM incidence. We investigated the association between NAFLD improvement and T2DM incidence.
RESEARCH DESIGN AND METHODS
Between 2000 and 2012, 4,604 participants who underwent a health check twice with > 10 years between were enrolled. Exclusion criteriawere positive hepatitis B surface antigen, positive hepatitis C antibody, ethanol intake > 20 g/day, and diabetes. The 3,074 eligible participants were divided into an NAFLD group (n = 728) and a non-NAFLD group (n = 2,346) according to ultrasonography-detected fatty liver. The NAFLD group was categorized into an improved group (n = 110) and a sustained NAFLD group (n = 618) based on fatty liver disappearance at the second visit. Incident T2DM odds ratios (ORs) were estimated by logistic regression models adjusted for age, sex, BMI, impaired fasting glucose, family history of diabetes, dyslipidemia, hypertension, and physical exercise.
RESULTS
T2DM occurred in 117 participants (16.1%) in the NAFLD group and 72 (3.1%) in the non-NAFLD group. NAFLD at baseline was associated with T2DM incidence (multivariate OR 2.37 [95% CI 1.60-3.52]). T2DM occurred in 7 participants (6.4%) in the improved group and in 110 (17.8%) in the sustained NAFLD group. NAFLD improvement was associated with reduced T2DM incidence (multivariate OR 0.27 [95% CI 0.12-0.61]).
CONCLUSIONS
NAFLD improvement is associated with T2DM incidence reduction.
- リンク情報
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- DOI
- https://doi.org/10.2337/dc15-0140
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/26156527
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000363416500021&DestApp=WOS_CPL
- URL
- http://orcid.org/0000-0002-9034-4370
- ID情報
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- DOI : 10.2337/dc15-0140
- ISSN : 0149-5992
- eISSN : 1935-5548
- ORCIDのPut Code : 25707926
- PubMed ID : 26156527
- Web of Science ID : WOS:000363416500021