論文

査読有り
2015年9月

Independent Association Between Improvement of Nonalcoholic Fatty Liver Disease and Reduced Incidence of Type 2 Diabetes

DIABETES CARE
  • Hajime Yamazaki
  • ,
  • Toru Tsuboya
  • ,
  • Kunihiko Tsuji
  • ,
  • Mitsuru Dohke
  • ,
  • Hiroyuki Maguchi

38
9
開始ページ
1673
終了ページ
1679
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.2337/dc15-0140
出版者・発行元
AMER DIABETES ASSOC

OBJECTIVE
Only a few studies have evaluated the long-term effects of nonalcoholic fatty liver disease (NAFLD) on type 2 diabetes mellitus (T2DM), and none have examined whether NAFLD improvement reduces T2DM incidence. We investigated the association between NAFLD improvement and T2DM incidence.
RESEARCH DESIGN AND METHODS
Between 2000 and 2012, 4,604 participants who underwent a health check twice with > 10 years between were enrolled. Exclusion criteriawere positive hepatitis B surface antigen, positive hepatitis C antibody, ethanol intake > 20 g/day, and diabetes. The 3,074 eligible participants were divided into an NAFLD group (n = 728) and a non-NAFLD group (n = 2,346) according to ultrasonography-detected fatty liver. The NAFLD group was categorized into an improved group (n = 110) and a sustained NAFLD group (n = 618) based on fatty liver disappearance at the second visit. Incident T2DM odds ratios (ORs) were estimated by logistic regression models adjusted for age, sex, BMI, impaired fasting glucose, family history of diabetes, dyslipidemia, hypertension, and physical exercise.
RESULTS
T2DM occurred in 117 participants (16.1%) in the NAFLD group and 72 (3.1%) in the non-NAFLD group. NAFLD at baseline was associated with T2DM incidence (multivariate OR 2.37 [95% CI 1.60-3.52]). T2DM occurred in 7 participants (6.4%) in the improved group and in 110 (17.8%) in the sustained NAFLD group. NAFLD improvement was associated with reduced T2DM incidence (multivariate OR 0.27 [95% CI 0.12-0.61]).
CONCLUSIONS
NAFLD improvement is associated with T2DM incidence reduction.

リンク情報
DOI
https://doi.org/10.2337/dc15-0140
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26156527
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000363416500021&DestApp=WOS_CPL
URL
http://orcid.org/0000-0002-9034-4370
ID情報
  • DOI : 10.2337/dc15-0140
  • ISSN : 0149-5992
  • eISSN : 1935-5548
  • ORCIDのPut Code : 25707926
  • PubMed ID : 26156527
  • Web of Science ID : WOS:000363416500021

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