Nabekura Tsukasa

J-GLOBAL         Last updated: Oct 3, 2019 at 03:03
 
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Name
Nabekura Tsukasa
E-mail
nabekura.tsukasa.feu.tsukuba.ac.jp
URL
http://immuno-tsukuba.com/index.html
Affiliation
University of Tsukuba
Section
Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA)
Job title
Assistant Professor
Degree
Ph.D.(University of Tsukuba)
Other affiliation
University of California, San Francisco
Research funding number
80550095

Research Areas

 
 

Academic & Professional Experience

 
Apr 2018
   
 
Assistant Professor, Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba
 
Mar 2014
 - 
Mar 2018
International Tenure-track Assistant Professor, Life Science Center of Tsukuba Advanced Research Alliance (TARA), University of Tsukuba
 
Nov 2014
 - 
Oct 2016
Specialist, Department of Microbiology and Immunology, Lewis L. Lanier lab, University of California, San Francisco
 
Nov 2011
 - 
Oct 2014
Postdoctoral Scholar, Department of Microbiology and Immunology, Lewis L. Lanier lab, University of California, San Francisco
 
Apr 2008
 - 
Oct 2011
Postdoctoral fellow, Graduate School of Comprehensive Human Sciences, University of Tsukuba
 

Education

 
Apr 2005
 - 
Mar 2008
Doctoral Program in Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukub
 

Committee Memberships

 
Apr 2018
 - 
Mar 2019
The 7th Retreat of Univ. of Tsukuba and Tokyo Univ. of Science  Program committee member
 
Apr 2019
 - 
Mar 2022
The Japanese Society for Immunology  Councilor
 
Apr 2017
 - 
Mar 2018
the 6th Retreat of Univ. of Tsukuba and Tokyo Univ. of Science  Management Secretariat
 
Apr 2017
 - 
Mar 2018
The Japanese Society for Immunology  Cooperation Committee Member
 

Awards & Honors

 
Nov 2018
Young Investigator Award in University of Tsukuba
 
Feb 2018
BEST FACULTY MEMBER in University of Tsukuba, University of Tsukuba
 
Dec 2017
The Japanese Society of Immunology Young Investigator Award
 
May 2013
AAI Trainee Abstract Award of IMMUNOLOGY 2013 Annual Meeting, The American Association of Immunologists, American Association of Immunologists
 
Nov 2012
Postdoctoral Fellowship for Research Abroad of the Japan Society for the Promotion of Science (JSPS), Japan Society for the Promotion of Science
 

Published Papers

 
Yoshida, Hideyuki; Lareau, Caleb A; Ramirez, Ricardo N; Rose, Samuel A; Maier, Barbara; Wroblewska, Aleksandra; Desland, Fiona; Chudnovskiy, Aleksey; Mortha, Arthur; Dominguez, Claudia; Tellier, Julie; Kim, Edy; Dwyer, Dan; Shinton, Susan; Nabekura, Tsukasa; Qi, YiLin; Yu, Bingfei; Robinette, Michelle; Kim, Ki-Wook; Wagers, Amy; Rhoads, Andrew; Nutt, Stephen L; Brown, Brian D; Mostafavi, Sara; Buenrostro, Jason D; Benoist, Christophe;
Cell   176(4) 897-912.e20   2019   [Refereed]
A complete chart of cis-regulatory elements and their dynamic activity is necessary to understand the transcriptional basis of differentiation and function of an organ system. We generated matched epigenome and transcriptome measurements in 86 pri...
Nabekura, Tsukasa;Chen, Zhiying;Schroeder, Casey;Park, Taeju;Vivier, Eric;Lanier, Lewis L.;Liu, Dongfang
AMER ASSOC IMMUNOLOGISTS   200(10) 3420-3428   2018   [Refereed]
Natural killer cells are critical in the immune response to infection and malignancy. Prior studies have demonstrated that Crk family proteins can influence cell apoptosis, proliferation, and cell transformation. In this study, we investigated the...
Nabekura, Tsukasa; Gotthardt, Dagmar; Niizuma, Kouta; Trsan, Tihana; Jenus, Tina; Jonjic, Stipan; Lanier, Lewis L
JOURNAL OF IMMUNOLOGY   199(5) 1567-1571   Sep 2017   [Refereed]
NK cells play a critical role in host defense against viruses. In this study, we investigated the role of NKG2D in the expansion of NK cells after mouse CMV (MCMV) infection. Wild-type and NKG2D-deficient (Klrk1(-/-) ) Ly49H(+) NK cells proliferat...
Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets
Robinette ML, Fuchs A, Cortez VS, Lee JS, Wang Y, Durum SK, Gilfillan S,;Shaw L, Yu B, Goldrath A, Mostafavi S, Regev A, Kim EY, Dwyer DF, Brenner MB, Austen KF, Rhoads A, Moodley D, Yoshida H;Mathis D, Benoist C;Nabekura, Tsukasa;Lam V, Lanier LL, Brown B, Merad M, Cremasco V, Turley S, Monach P, Dustin ML, Li Y;Shinton SA, Hardy RR, Shay T, Qi Y, Sylvia K, Kang J, Fairfax K, Randolph GJ, Robinette ML, Fuchs A, Colonna M
Natuire Immunology   16 306   2015   [Refereed]
The recognized diversity of innate lymphoid cells (ILCs) is rapidly expanding. Three ILC classes have emerged, ILC1, ILC2 and ILC3, with ILC1 and ILC3 including several subsets. The classification of some subsets is unclear, and it remains controv...
Expression profiling of constitutive mast cells reveals a unique identity within the immune system
Dwyer DF, Barrett NA, Austen KF, Kim EY, Brenner MB, Shaw L, Yu B;Goldrath A, Mostafavi S, Regev A, Rhoades A, Moodley D, Yoshida H, Mathis D, Benoist C;Nabekura, Tsukasa;Lam V, Lanier LL, Brown B, Merad M, Cremasco V, Turley S, Monach P, Dustin ML, Li Y, Shinton SA, Hardy RR, Shay T,;Qi Y, Sylvia K, Kang J, Fairfax K, Randolph GJ, Robinette ML, Fuchs A, Colonna M.
Nature Immunology   17 878   2016   [Refereed]
Mast cells are evolutionarily ancient sentinel cells. Like basophils, mast cells express the high-affinity receptor for immunoglobulin E (IgE) and have been linked to host defense and diverse immune-system-mediated diseases. To better characterize...

Books etc

 
An immunotherapy approach with dendritic cells genetically modified to express the tumor-associated antigen, HER2
Nabekura,Tsukasa
Mar 2008   

Conference Activities & Talks

 
Tracking the Fate of Antigen-specific Versus Cytokine-activated Natural Killer Cells after Cytomegalovirus Infection
Nabekura, Tsukasa
The 3rd International Conference of Innate Lymphoid Cel   Nov 2018   
Tracking the fate of antigen-specific versus cytokine-activated natural killer cells after cytomegalovirus infection [Invited]
Nabekura, Tsukasa
RIKEN Center for Integrative Medical Sciences (IMS) – Japanese Society of Immunology (JSI) International Symposium on Immunology 2018   Jun 2018   
活性化受容体NKG2D はマウスサイトメガロウイルス感染時のナチュラルキラー細胞の増殖を促進するが、NKG2D シグナル単独では増殖に不十分である
鍋倉, 宰
第6回筑波大学・東京理科大学合同リトリート   17 Mar 2018   
Tracking the fate of antigen-specific versus cytokine-activated natural killer cells after cytomegalovirus infection
Nabekura, Tsukasa
The 46th Annual Meeting of the Japanese Society of Immunology   Dec 2017   
共刺激分子DNAM-1はサイトメガロウイルス感染時に於ける記憶ナチュラルキラー分化に必要である
鍋倉 宰;金谷 穣;渋谷 彰;Guo, Fu;Gascoigne, Nicholas R.J;Lanier, Lewis L
第9回血液疾患・免疫療法学会学術集会   30 Sep 2017   

Research Grants & Projects

 
Identification of a master regulator of the differentiation of memory natural killer cells
Japan Society for the Promotion of Science: Grant-in-Aid for Young Scientists(A)
Project Year: Apr 2017 - Mar 2020

Patents

 
UC Case No: 2017-134, Research Tool Disclosure (invention) : NKp46-CreERT2 transgenic mice
Nabekura, Tsukasa;Lanier, L Lewis
Research Tool Disclosure (invention)
特許第6124261号 : 活性調節剤、これを含有する医薬品、および抗CD300a抗体
渋谷, 彰;小田 ちぐさ;田原 聡子;鍋倉 宰;カンカーナム ガマゲ サナトゥ ウダヤンガ;三木 春香;飯野 秀一
特願2012-245814 : セリアック病に関連する、CD300a遺伝子欠損マウスおよびCD300a発現細胞の活性調節剤の使用、ならびにCD300a発現細胞の活性調節剤を含有する医薬品
渋谷,彰;小田 ちぐさ;鍋倉 宰
WO/2013/077186 : Activity modulator, medical agent comprising same, use of CD300a gene-deficient mouse, and anti-CD330a antibody
鍋倉,宰

Others

 
Aug 2017
Menneki Fushigi Mirai 2017 (organized by Kenji Ishiwata, the Japanese Society for Immunology) at Tokyo, Japan.
May 2008
Menneki Hushigi Mirai 2008 (organized by Masayuki Miyasaka, the Japanese Society for Immunology) at Tokyo, Japan
Apr 2008
Menneki Town Meeting Tsukuba (organized by Akira Shibuya, the Japanese Society for Immunology) at Ibaraki, Japan.