2015年6月
IL-33 Receptor ST2 Amplifies the Expansion of NK Cells and Enhances Host Defense during Mouse Cytomegalovirus Infection
JOURNAL OF IMMUNOLOGY
- ,
- ,
- 巻
- 194
- 号
- 12
- 開始ページ
- 5948
- 終了ページ
- 5952
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.4049/jimmunol.1500424
- 出版者・発行元
- AMER ASSOC IMMUNOLOGISTS
NK cells provide important host defense against viruses and can differentiate into self-renewing memory NK cells after infection, alloantigen stimulation, and cytokine stimulation. In this study, we investigated the role of the IL-33 receptor ST2 in the differentiation of NK cells during mouse CMV (MCMV) infection. Although ST2-deficient (Il1rl1(-/-)) Ly49H(+) NK cells develop normally and differentiate into memory cells after MCMV infection, naive and memory Il1rl1(-/-) Ly49H(+) NK cells exhibited profound defects in MCMV-specific expansion, resulting in impaired protection against MCMV challenge. Additionally, IL-33 enhanced m157 Ag-specific proliferation of Ly49H(+) NK cells in vitro. Thus, an IL-33/ST2 signaling axis in NK cells contributes to host defense against MCMV.
- リンク情報
- ID情報
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- DOI : 10.4049/jimmunol.1500424
- ISSN : 0022-1767
- eISSN : 1550-6606
- Web of Science ID : WOS:000355757800040