2010年7月
Effect of concomitantly used fish oil and cholesterol on lipid metabolism.
J Nutr Biochem
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- ,
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- 巻
- 21
- 号
- 7
- 開始ページ
- 573
- 終了ページ
- 579
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.jnutbio.2009.02.013
- 出版者・発行元
- Elsevier
Although cholesterol plays various important roles in the body, when overconsumed, it causes atherosclerosis and results in ischemic heart disease. On the other hand, dietary fish oils contain n-3 fatty acids, such as eicosapentaenoic acid and docosahexaenoic acid, which prevent ischemic heart disease. This effect of n-3 fatty acids mainly results from the combined effects of inhibiting lipogenesis via a decrease of the mature form of sterol regulatory element-binding proteins (SREBPs) and stimulating fatty acid oxidation via peroxisome proliferator-activator receptor (PPAR) alpha activation in the liver. In this study, we examined the interactive effects on lipid metabolism of dietary 2% cholesterol (w/w) and 20% or 50% energy fish oil. In a safflower oil diet with 2% cholesterol, hepatic lipids accumulated. On the other hand, hepatic lipids did not accumulate in the fish oil diets with cholesterol. Furthermore, in the groups with fish oil energy ratios of 20%, the negative feedback control of cholesterol affected SREBP-2, and the actions of fish oil and cholesterol were equivalent, but this was not observed in the cases with fish oil energy ratios of 50%. The results of this
- リンク情報
- ID情報
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- DOI : 10.1016/j.jnutbio.2009.02.013
- ISSN : 1873-4847
- CiNii Articles ID : 120005518470
- CiNii Books ID : AA10748929
- PubMed ID : 19447021