論文

査読有り
2018年

Coumarins with anti-melanogenesis activities from a chemically engineered extract of a marine-derived fungus

Heterocycles
  • Hitoshi Kamauchi
  • ,
  • Kaoru Kinoshita
  • ,
  • Kiyotaka Koyama

96
2
開始ページ
273
終了ページ
285
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3987/COM-17-13854
出版者・発行元
Japan Institute of Heterocyclic Chemistry

Chemical investigation of new resources is critical for developing medicinal leads. Chemically engineered extracts, a technique for derivatization of natural extracts, was performed on crude extracts of marine-derived fungus Eurotium rubrum
the resulting reaction mixture exhibited enhanced tyrosinase inhibition. Coumarin derivatives (1-3) were isolated from this chemically engineered extract. The structures of 1-3 were established using NMR, MS, and IR methods, revealing coumarin structures with side chains biosynthesized by the acetate-malonate pathway. 1-3 showed tyrosinase inhibition (IC50 = 7.7, 13.3, and 9.5 μM, respectively) and anti-melanogenesis activity (IC50 = 6.6, 7.2, and 6.6 μM, respectively, against B16 melanoma cells).

リンク情報
DOI
https://doi.org/10.3987/COM-17-13854
ID情報
  • DOI : 10.3987/COM-17-13854
  • ISSN : 1881-0942
  • ISSN : 0385-5414
  • SCOPUS ID : 85042152951

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