論文

査読有り
2018年5月25日

Isoindolinones, Phthalides, and a Naphthoquinone from the Fruiting Body of Daldinia concentrica

Journal of Natural Products
  • Hitoshi Kamauchi
  • ,
  • Yuki Shiraishi
  • ,
  • Akiyo Kojima
  • ,
  • Naoki Kawazoe
  • ,
  • Kaoru Kinoshita
  • ,
  • Kiyotaka Koyama

81
5
開始ページ
1290
終了ページ
1294
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1021/acs.jnatprod.7b00976
出版者・発行元
American Chemical Society

A chemical investigation of the ascomycetes of Daldinia concentrica was performed using silica gel column chromatography, ODS column chromatography, and preparative HPLC. Two new isoindolinone compounds, daldinans B (1) and C (2), two new phthalide compounds, daldinolides A (3) and B (4), and a new naphthoquinone, daldiquinone (5), were isolated together with two known compounds (6 and 7). The structures of 1, 2, and 5 were established using NMR, MS, and IR methods, and the structures of 3 and 4 were determined by derivatization from known compounds (6 and 7). 5 exhibited antiangiogenesis activity against HUVECs (IC50 = 7.5 μM).

リンク情報
DOI
https://doi.org/10.1021/acs.jnatprod.7b00976
ID情報
  • DOI : 10.1021/acs.jnatprod.7b00976
  • ISSN : 1520-6025
  • ISSN : 0163-3864
  • SCOPUS ID : 85047521722

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