論文

査読有り
2016年10月

Conditional changes enhanced production of bioactive metabolites of marine derived fungus Eurotium rubrum

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  • Hitoshi Kamauchi
  • ,
  • Kaoru Kinoshita
  • ,
  • Takashi Sugita
  • ,
  • Kiyotaka Koyama

26
20
開始ページ
4911
終了ページ
4914
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.bmcl.2016.09.017
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

Metabolites of marine derived fungus Eurotium rubrum MPUC136 differed between cultivation on wheat medium and Czapek-Dox agar medium. Melanin synthesis inhibitory activity of crude extract of culture on wheat medium showed stronger activity than that of crude extract of culture on Czapek-Dox agar medium. A new diketopiperazine compound isoechinulin D (1) and eight reported diketopiperazines (2-9) were isolated from the crude extract of wheat medium. The structure of 1 was established using NMR, MS and IR methods. 2-5 inhibited melanogenesis using B16 melanoma cells (IC50 = 68, 2.4, 83, 9.1 mu M each). Structure-Activity-Relationships of diketopiperazines (1-10) indicated the importance of the prenyl groups at C-2, C-5 and C-7, the vinyl group at C-12 to C-25 and the sp(2) carbons at C-8 and C-9. Isolated compounds (1-9) were not or slightly observed from the extracts of Czapek-Dox agar medium by HPLC analysis, suggesting that different cultivation processes could affect metabolism and enhance bioactivities. (C) 2016 Elsevier Ltd. All rights reserved.

Web of Science ® 被引用回数 : 10

リンク情報
DOI
https://doi.org/10.1016/j.bmcl.2016.09.017
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000385498500012&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.bmcl.2016.09.017
  • ISSN : 0960-894X
  • eISSN : 1464-3405
  • Web of Science ID : WOS:000385498500012

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