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The diversity of natural compounds is extensive but not unlimited. Fermentation of rhizomes of Atractylodes lancea by marine fungus (Cladosporium cladosporioides) enhanced the diversity of natural compounds. From the fermented rhizomes of A. lancea, two new spirovetivane-type sesquiterpenoids, 2-oxo-12-hydroxy-hinesol (1) and 2-oxo-15-hydroxy-hinesol (2); a new guaiane-type sesquiterpenoid atractylol A (3); and three new eudesmane-type sesquiterpenoids, 14-hydroxy-isopterocarpolone (4), 3 alpha-hydroxy-pterocarpol (5), and (11R)-2, 11, 12-trihydroxy-beta-selinene (6), were isolated along with known sesquiterpenoids (7-10). The structures of these compounds were established using NMR, MS, and IR methods. These compounds (1-6) were not observed in A. lancea extracts by TLC and HPLC analysis, suggesting that these compounds were generated during the fermentation process. (C) 2015 Elsevier Ltd. All rights reserved.
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- DOI : 10.1016/j.tet.2015.02.041
- ISSN : 0040-4020
- Web of Science ID : WOS:000352747900002