論文

査読有り
2014年12月

Three new terpenoids, sterebins O, P1, and P2, isolated from Stevia rebaudiana fermented by Saccharomyces cerevisiae

TETRAHEDRON LETTERS
  • Hitoshi Kamauchi
  • ,
  • Tatsuhiko Kon
  • ,
  • Kaoru Kinoshita
  • ,
  • Kunio Takahashi
  • ,
  • Kiyotaka Koyama

55
52
開始ページ
7203
終了ページ
7205
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.tetlet.2014.11.012
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

The diversity of natural compounds is extensive but not unlimited. We therefore studied the feasibility of fermenting plant extracts to increase the diversity of natural compounds for use as drug candidates. Three new terpenoids, sterebins O (1), P1 (2), and P2 (3), were isolated from an extract of Stevia rebaudiana fermented by Saccharomyces cerevisiae. The structures of these compounds were established using NMR, MS, and IR methods. The absolute configuration of 1 was determined by X-ray diffraction analysis, and that of 2 and 3 from the ECD spectrum of their benzoate derivatives. These three compounds were not observed in S. rebaudiana extracts by TLC, suggesting that the compounds were generated during the fermentation process. Compounds 1, 2, and 3 all inhibited melanogenesis in theophylline-stimulated B16 melanoma cells, with 1 exhibiting the lowest IC50 value (9.8 mu M). The results indicate that fermentation of plant extracts may provide a route for generating many useful compounds. (C) 2014 Elsevier Ltd. All rights reserved.

Web of Science ® 被引用回数 : 11

リンク情報
DOI
https://doi.org/10.1016/j.tetlet.2014.11.012
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000347602400011&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.tetlet.2014.11.012
  • ISSN : 0040-4039
  • Web of Science ID : WOS:000347602400011

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