Hitoshi Kamauchi - My portal

Profile Information

Affiliation: Assistant Professor, Faculty of Pharmaceutical Sciences Department of Pharmaceutical Technochemistry, Josai University

Degree: 博士 (薬科学)(Mar, 2018, 明治薬科大学)

Researcher number: 40825402
J-GLOBAL ID: 201801016234637918
researchmap Member ID: 7000024463

Research Interests

Natural product science

Research Areas

Research History

Apr, 2022 - Present

Faculty of Pharmaceutical Sciences Department of Pharmaceutical, Josai University
Apr, 2018 - Mar, 2022

Research Assistant, Faculty of Pharmaceutical Sciences Department of Pharmaceutical Technochemistry, Josai University
Apr, 2011 - Mar, 2013

Faculty of Pharmacy, Meiji Pharmaceutical University

Education

Apr, 2015 - Mar, 2018

Graduate School, Division of Pharmaceutical Sciences, Meiji Pharmaceutical University
Apr, 2013 - Mar, 2015

Graduate School, Division of Pharmaceutical Sciences, Meiji Pharmaceutical University
Apr, 2006 - Mar, 2010

Faculty of Pharmaceutical Science, Meiji Pharmaceutical University

Awards

Mar, 2023

長井記念若手薬学研究者賞, 日本薬学会

鎌内等
2016

平成28年度長井記念薬学研究奨励支援, 日本薬学会

鎌内等

Papers

Synthesis and Biological Evaluation of 2-Azolylmethylene-3-(2H)-benzofuranone Derivatives as Potent Monoamine Oxidases Inhibitors

Koichi Takao, Yuka Kubota, Kota Kurosaki, Hitoshi Kamauchi, Yoshihiro Uesawa, Yoshiaki Sugita

Chemical and Pharmaceutical Bulletin, 72(1) 109-120, Jan 23, 2024 Peer-reviewed
A Tricyclic Aromatic Polyketide Isolated from the Marine-Derived Fungus Curvularia aeria

Hitoshi Kamauchi, Mayu Tanaka, Mitsuaki Suzuki, Miho Furukawa, Atsushi Ikeda, Chihiro Sasho, Yuka Kiba, Masashi Kitamura, Koichi Takao, Yoshiaki Sugita

Chemical and Pharmaceutical Bulletin, 72(1) 98-101, Jan 18, 2024 Peer-reviewedLead authorCorresponding author
Synthesis of 2,8-Dioxabicyclo[3.3.1]nonane Derivatives and Their Neuroprotective Activities

Hitoshi Kamauchi, Masafumi Takanashi, Mitsuaki Suzuki, Kouki Izumi, Koichi Takao, Yoshiaki Sugita

Chemical and Pharmaceutical Bulletin, 72(1) 56-60, Jan 1, 2024 Peer-reviewedLead authorCorresponding author
Inhibition of furin-like enzymatic activities and SARS-CoV-2 infection by osthole and phenolic compounds with aryl side chains.

Yuka Kiba, Takashi Tanikawa, Tsuyoshi Hayashi, Hitoshi Kamauchi, Taishi Seki, Ryuichiro Suzuki, Masashi Kitamura

Biomedicine & pharmacotherapy, 169 115940-115940, Nov 25, 2023
Total Synthesis and Monoamine Oxidase Inhibitory Activities of (±)-Entonalactam A and Its Derivatives

Hitoshi Kamauchi, Momoka Hirata, Koichi Takao, Yoshiaki Sugita

ACS Omega, 7(45) 41804-41814, Nov 15, 2022 Peer-reviewedLead authorCorresponding author
Antifungal activity of dehydrocurvularin for Candida spp. through the inhibition of adhesion to human adenocarcinoma cells

Hitoshi Kamauchi, Miho Furukawa, Yuka Kiba, Masashi Kitamura, Kanako Usui, Masanori Katakura, Koichi Takao, Yoshiaki Sugita

The Journal of Antibiotics, 75 530-533, Sep, 2022 Peer-reviewedLead authorCorresponding author
A benzaldehyde derivative obtained from Hypoxylon truncatum NBRC 32353 treated with hygromycin B

Hitoshi Kamauchi, Mitsuaki Suzuki, Koichi Takao, Yoshiaki Sugita

The Journal of Antibiotics, 75 1-8, Jan, 2022 Peer-reviewedLead authorCorresponding author
Inhibition of BACE1 and Amyloid‑β Aggregation by Meroterpenoids from the Mushroom Albatrellus yasudae

Youki Masuda, Koji Fujihara, Satoshi Hayashi, Hiroaki Sasaki, Yoshihiro Kino, Hitoshi Kamauchi, Masahiro Noji, Jun-ichi Satoh, Toshikatsu Takanami, Kaoru Kinoshita …

Journal of Natural Products, 84 1748-1754, Jun 8, 2021 Peer-reviewed
Synthesis and biological evaluation of 3-styrylchromone derivatives as selective monoamine oxidase B inhibitors

Koichi Takao, Yuri Takemura, Junko Nagai, Hitoshi Kamauchi, Kaori Hoshi, Ryo Mabashi, Yoshihiro Uesawa, Yoshiaki Sugita

Bioorganic and Medicinal Chemistry, 42 116255-116255, Jun 5, 2021 Peer-reviewed
Synthesis and antifungal activity of polycyclic pyridone derivatives with anti-hyphal and biofilm formation activity against Candida albicans

Hitoshi Kamauchi, Yu Kimura, Mikoto Ushiwatari, Mitsuaki Suzuki, Taishi Seki, Koichi Takao, Yoshiaki Sugita

Bioorganic & Medicinal Chemistry Letters, 37(1) 127845-127845, Apr, 2021 Peer-reviewedLead authorCorresponding author
Synthesis and pharmacological evaluation of childinin E and several derivatives as anti-hyphal formation inhibitors against Candida albicans

Hitoshi Kamauchi, Momoka Hirata, Koichi Takao, Yoshiaki Sugita

Tetrahedron Letters, 61(49) 152588-152588, Dec, 2020 Peer-reviewedLead authorCorresponding author
Syntheses and Evaluation of 2- or 3-(N-Cyclicamino)chromone Derivatives as Monoamine Oxidase Inhibitors

Koichi Takao, Tsukasa Sakatsume, Hitoshi Kamauchi, Yoshiaki Sugita

Chemical and Pharmaceutical Bulletin, 68(11) 1082-1089, Nov 1, 2020 Peer-reviewed
Antifungal Compound Against Azole－Resistant Candida albicans from a Marine-Derived Fungus, Paraboeremia selaginellae

Eri Yamaguchi, Kazuha Okabe, Hitoshi Kamauchi, Sanae Kurakado, Takashi Sugita, Kaoru Kinoshita, Kiyotaka Koyama

HETEROCYCLES, 100(4) 65-652, Apr, 2020 Peer-reviewed
Synthesis of natural product-like polyprenylated phenols and quinones: Evaluation of their neuroprotective activities

Hitoshi Kamauchi, Takumi Oda, Kanayo Horiuchi, Koichi Takao, Yoshiaki Sugita

Bioorganic and Medicinal Chemistry, 28(1) 115156-115156, Jan, 2020 Peer-reviewedLead authorCorresponding author
2-Styrylchromone derivatives as potent and selective monoamine oxidase B inhibitors.

Koichi Takao, Saki Endo, Junko Nagai, Hitoshi Kamauchi, Yuri Takemura, Yoshihiro Uesawa, Yoshiaki Sugita

Bioorganic chemistry, 92 103285-103285, Nov, 2019 Peer-reviewed
A New γ-Butenolide Glycoside from The Root of Styphonolobium Japonicum

Takahiro Utsumi, Ryuichiro Suzuki, Hitoshi Kamauchi, Sae Misawa, Masashi Kitamura, Yoshiaki Sugita, Yoshiaki Shirataki

HETEROCYCLES, 98(9) 1251-1257, Oct 1, 2019 Peer-reviewed
Design, synthesis and evaluation of 2-(indolylmethylidene)-2,3-dihydro-1-benzofuran-3-one and 2-(indolyl)-4H-chromen-4-one derivatives as novel monoamine oxidases inhibitors

Takao, K., U, S., Kamauchi, H., Sugita, Y.

Bioorganic Chemistry, 87 594-600, Mar 16, 2019 Peer-reviewed
Synthesis and biological evaluation of pyrano[4,3-b][1]benzopyranone derivatives as monoamine oxidase and cholinesterase inhibitors

Takao, K., Kubota, Y., Kamauchi, H., Sugita, Y.

Bioorganic Chemistry, 83 432-437, 2019 Peer-reviewed
Coumarins with an unprecedented tetracyclic skeleton and coumarin dimers from chemically engineered extracts of a marine-derived fungus

Hitoshi Kamauchi, Masahiro Noji, Kaoru Kinoshita, Toshikatsu Takanami, Kiyotaka Koyama

Tetrahedron, 74(23) 2846-2856, Jun 7, 2018 Peer-reviewedLead author
Isoindolinones, Phthalides, and a Naphthoquinone from the Fruiting Body of Daldinia concentrica

Hitoshi Kamauchi, Yuki Shiraishi, Akiyo Kojima, Naoki Kawazoe, Kaoru Kinoshita, Kiyotaka Koyama

Journal of Natural Products, 81(5) 1290-1294, May 25, 2018 Peer-reviewedLead author

Misc.

Discovery of Medicinal Seeds from Chemically Engineered Extracts

Journal of Synthetic Organic Chemistry, Japan, 77(9) 895-903, Sep 1, 2019 Peer-reviewedInvitedLead authorCorresponding author
エンドファイト; 特殊環境が生み出す可能性

鎌内等

ファルマシア, 49(4) 333-333, Apr, 2013 Peer-reviewedInvitedLead author

Presentations

クロサイワイタケ科キノコ由来イソインドリノン化合物の合成

鎌内等, 杉田義昭

第65回天然有機化合物討論会, Sep, 2023
菌糸-バイオフィルム形成阻害をターゲットとした真菌由来天然物の誘導体合成

鎌内等, 木村由, 牛渡美琴, 關大志, 鈴木光明, 平田桃香, 高尾浩一, 杉田義昭

第63回天然有機化合物討論会, Sep, 2021
芳香族-テルペノイド天然物の誘導体合成と神経保護作用の評価

鎌内等, 小田拓未, 堀内加奈世, 高尾浩一, 杉田義昭

第61回天然有機化合物討論会, Sep, 2019

Professional Memberships

Research Projects

天然由来化合物を基盤とした菌糸形成阻害による「予防的」抗真菌薬の開発

科学研究費助成事業, 若手研究, 日本学術振興会, Apr, 2020 - Mar, 2023

鎌内等