論文

2011年6月1日

Role of guanylyl cyclase modulation in mouse cone phototransduction

The Journal of neuroscience : the official journal of the Society for Neuroscience
  • Sakurai, Keisuke
  • ,
  • Chen, Jeannie
  • ,
  • Kefalov, Vladimir J

31
22
開始ページ
7991
終了ページ
8000
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1523/JNEUROSCI.6650-10.2011

A negative phototransduction feedback in rods and cones is critical for the timely termination of their light responses and for extending their function to a wide range of light intensities. The calcium feedback mechanisms that modulate phototransduction in rods have been studied extensively. However, the corresponding modulation mechanisms that enable cones to terminate rapidly their light responses and to adapt in bright light, properties critical for our daytime vision, are still not understood. In cones, calcium feedback to guanylyl cyclase is potentially a key step in phototransduction modulation. The guanylyl cyclase activity is modulated by the calcium-binding guanylyl cyclase activating proteins (GCAP1 and GCAP2). Here, we used single-cell and transretinal recordings from mouse to determine how GCAPs modulate dark-adapted responses as well as light adaptation in mammalian cones. Deletion of GCAPs increased threefold the amplitude and dramatically prolonged the light responses in dark-adapted mouse cones. It also reduced the operating range of mouse cones in background illumination and severely impaired their light adaptation. Thus, GCAPs exert powerful modulation on the mam

リンク情報
DOI
https://doi.org/10.1523/JNEUROSCI.6650-10.2011
ID情報
  • DOI : 10.1523/JNEUROSCI.6650-10.2011
  • ISSN : 1529-2401

エクスポート
BibTeX RIS