論文

国際誌
2020年4月

GABA-Induced GnRH Release Triggers Chordate Metamorphosis

Current biology : CB
  • Hozumi, Akiko
  • Matsunobu, Shohei
  • Mita, Kaoru
  • Treen, Nicholas
  • Sugihara, Takaho
  • Horie, Takeo
  • Sakuma, Tetsushi
  • Yamamoto, Takashi
  • Shiraishi, Akira
  • Hamada, Mayuko
  • Satoh, Noriyuki
  • Sakurai, Keisuke
  • Satake, Honoo
  • Sasakura, Yasunori
  • 全て表示

30
8
開始ページ
1555-1561.e4
終了ページ
1561
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.cub.2020.02.003
出版者・発行元
CELL PRESS

Metamorphosis, a widespread life history strategy in metazoans, allows dispersal and use of different ecological niches through a dramatic body change from a larval stage [1, 2]. Despite its conservation and importance, the molecular mechanisms underlying its initiation and progression have been characterized in only a few animal models. In this study, through pharmacological and gene functional analyses, we identified neurotransmitters responsible for metamorphosis of the ascidian Ciona. Ciona metamorphosis converts swimming tadpole larvae into vase-like, sessile adults. Here, we show that the neurotransmitter GABA is a key regulator of metamorphosis. We found that gonadotropin-releasing hormone (GnRH) is a downstream neuropeptide of GABA. Although GABA is generally thought of as an inhibitory neurotransmitter, we found that it positively regulates secretion of GnRH through the metabotropic GABA receptor during Ciona metamorphosis. GnRH is necessary for reproductive maturation in vertebrates, and GABA is an important excitatory regulator of GnRH in the hypothalamus during puberty [3, 4]. Our findings reveal another role of the GABA-GnRH axis in the regulation of post-embryonic dev

リンク情報
DOI
https://doi.org/10.1016/j.cub.2020.02.003
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32220316
ID情報
  • DOI : 10.1016/j.cub.2020.02.003
  • ISSN : 1879-0445
  • PubMed ID : 32220316

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