論文

国際誌
2020年11月24日

A Simple Prognostic Benefit Scoring System for Sarcoma Patients with Pulmonary Metastases: Sarcoma Lung Metastasis Score.

Annals of surgical oncology
  • Haruchika Yamamoto
  • ,
  • Hiromasa Yamamoto
  • ,
  • Junichi Soh
  • ,
  • Etsuji Suzuki
  • ,
  • Kei Namba
  • ,
  • Ken Suzawa
  • ,
  • Kentaroh Miyoshi
  • ,
  • Shinji Otani
  • ,
  • Mikio Okazaki
  • ,
  • Seiichiro Sugimoto
  • ,
  • Masaomi Yamane
  • ,
  • Takashi Yorifuji
  • ,
  • Katsuhito Takahashi
  • ,
  • Shinichi Toyooka

記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1245/s10434-020-09272-1

BACKGROUND: Pulmonary metastasectomy could be considered one of the treatment options for disease control in sarcoma patients with pulmonary metastases; however, there is little consensus regarding the suitable criteria for predicting the likely outcomes in these patients. The aim of this study was to establish a prognostic benefit scoring system based on preoperatively examined prognostic factors for sarcoma patients with pulmonary metastases. METHODS: This was a single-center, retrospective cohort study conducted in a cohort of 135 sarcoma patients who underwent a first pulmonary metastasectomy at Okayama University Hospital between January 2006 and December 2015. Based on the results of a multivariable logistic regression analysis performed to determine the factors influencing 3-year mortality, a Sarcoma Lung Metastasis Score was created and its correlation with 3-year survival was analyzed. RESULTS: The results of the multivariate analysis revealed significant differences in the disease-free interval (< 2 years vs. ≥ 2 years; odds ratio (OR) 4.22, 95% confidence interval (CI) 1.67-10.70), maximum tumor diameter (≥ 15 mm vs. < 15 mm; OR 3.86, 95% CI 1.75-8.52), and number of pulmonary metastases (≥ 6 vs. < 6; OR 2.65, 95% CI 1.06-6.620). The Sarcoma Lung Metastasis Score, which was defined as the total score of these three factors, reliably predicted 3-year survival (score: 0, 89.5%; 1, 63.2%; 2, 39.0%; 3, 10.5%). CONCLUSIONS: Our newly proposed simple Sarcoma Lung Metastasis Score appears to be a useful prognostic predictor for sarcoma patients with pulmonary metastases, in that it could be helpful for the selection of appropriate treatments for these patients.

リンク情報
DOI
https://doi.org/10.1245/s10434-020-09272-1
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33236252

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