2014年3月
An extended steepness model for leg-size determination based on Dachsous/Fat trans- dimer system
SCIENTIFIC REPORTS
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- 巻
- 4
- 号
- 開始ページ
- 4335
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/srep04335
- 出版者・発行元
- NATURE PUBLISHING GROUP
What determines organ size has been a long-standing biological question. Lawrence et al. (2008) proposed the steepness hypothesis suggesting that the protocadherin Dachsous/Fat (Ds/Ft) system may provide some measure of dimension to the cells in relation to the gradient. In this paper we extended the model as a means of interpreting experimental results in cricket leg regeneration. We assumed that (1) Ds/Ft trans-heterodimers or trans-homodimers are redistributed during cell division, and (2) growth would cease when a differential of the dimer across each cell decreases to a certain threshold. We applied our model to simulate the results obtained by leg regeneration experiments in a cricket model. The results were qualitatively consistent with the experimental data obtained for cricket legs by RNA interference methodology. Using our extended steepness model, we provided a molecular-based explanation for leg size determination even in intercalary regeneration and for organ size determination.
- リンク情報
- ID情報
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- DOI : 10.1038/srep04335
- ISSN : 2045-2322
- Web of Science ID : WOS:000332534800001