2010年
Immunoglobulin G4 (IgG4)-positive or –negative ocular adnexal benign lymphoid lesions in relation to systemic involvement.
Journal of Clinical and Experimental Hematopathology
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 50
- 号
- 2
- 開始ページ
- 129
- 終了ページ
- 142
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.3960/jslrt.50.129
- 出版者・発行元
- The Japanese Society for Lymphoreticular Tissue Research
The purpose of this study is to determine the relationship of ocular adnexal benign or reactive lymphoid hyperplasia, including orbital pseudotumor, with immunoglobulin G4 (IgG4)-related diseases. Medical charts of 9 consecutive patients with ocular adnexal benign lymphoid lesions, seen in the Department of Ophthalmology, Okayama University Hospital, were reviewed, and pathological sections were restained immunohistochemically for IgG4-, IgG-, and CD138-positive plasma cells. The diagnosis of IgG4-positive lesions was based on 10 or more IgG4-positive plasma cells in a high-power field and greater than 40% ratios of IgG4-positive plasma cells/CD138-positive plasma cells and IgG4-positive plasma cells/IgG-positive plasma cells. IgG4-positive lesions were determined as absent in 5 patients (4 with bilateral lacrimal/orbital lesions and one with a unilateral conjunctival lesion), none of whom showed systemic manifestations. In contrast, IgG4-positive lesions were present in 4 patients (3 with bilateral lacrimal/orbital lesions and one with a unilateral lacrimal/orbital lesion), who showed systemic manifestations : one with Hashimoto thyroiditis, one with IgG4-positive bilateral interstitial lung disease and hepatic inflammatory pseudotumor, one with bilateral interstitial lung disease, and one with systemic lymphadenopathy and antiphospholipid syndrome. In conclusion, IgG4-positive ocular adnexal benign lymphoid lesions might be used as a benchmark for the probable presence of other systemic lymphoid lesions.
- リンク情報
- ID情報
-
- DOI : 10.3960/jslrt.50.129
- ISSN : 1346-4280
- CiNii Articles ID : 10027647972
- CiNii Books ID : AA11556796