2011年5月
Follicular variant of peripheral T-cell lymphoma mimicking follicular lymphoma: A case report with a review of the Literature
PATHOLOGY INTERNATIONAL
- 巻
- 61
- 号
- 5
- 開始ページ
- 326
- 終了ページ
- 330
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/j.1440-1827.2011.02656.x
- 出版者・発行元
- WILEY-BLACKWELL
Peripheral T-cell lymphoma (PTCL) with a follicular growth pattern is very rare. Herein, a case of follicular variant of PTCL in a 50-year-old man who complained of tonsillar and generalized lymph node swelling is reported. The resected tonsil revealed a vague nodular growth pattern of atypical cells, medium to large in size, with abundant pale cytoplasm. The lymphoma cells were CD3+ CD4+ CD5+ CD8- CD10+ CD56- CD57- BCL6+ PD-1+ CXCL13+ and were associated with a meshwork of CD21+ follicular dendritic cells. Molecular studies revealed clonal rearrangement of the T-cell receptor gamma chain gene but not of the immunoglobulin gene. Cytogenetic analysis disclosed a complex abnormality in 18 of 20 cells with the exclusion of t(5; 9). These findings suggest that the present case is a follicular variant of PTCL derived from follicular T-helper cells.
- リンク情報
- ID情報
-
- DOI : 10.1111/j.1440-1827.2011.02656.x
- ISSN : 1320-5463
- Web of Science ID : WOS:000289683200009