論文

2013年9月

B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma without mediastinal disease: mimicking nodular sclerosis classical Hodgkin lymphoma

MEDICAL MOLECULAR MORPHOLOGY
  • Noriko Iwaki
  • ,
  • Yasuharu Sato
  • ,
  • Toshiro Kurokawa
  • ,
  • Yoshinobu Maeda
  • ,
  • Kyotaro Ohno
  • ,
  • Mai Takeuchi
  • ,
  • Katsuyoshi Takata
  • ,
  • Yorihisa Orita
  • ,
  • Shinji Nakao
  • ,
  • Tadashi Yoshino

46
3
開始ページ
172
終了ページ
176
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00795-013-0038-8
出版者・発行元
SPRINGER JAPAN KK

B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma (BCLu-DLBCL/CHL), also known as gray-zone lymphoma, has overlapping clinical and biological characteristics of both diffuse large B-cell lymphoma and classical Hodgkin lymphoma (CHL). These lymphomas are typically associated with mediastinal disease, and extranodal involvement is rare. In the present report, we describe a case of a 78-year-old woman with BCLu-DLBCL/CHL found to have extranodal lesions and no evidence of mediastinal disease. Although biopsy specimens were histologically similar to nodular sclerosis CHL, the tumor cells were positive for CD30 and mature B-cell markers, such as CD20, CD79a, PAX5, BOB.1, and OCT-2, but negative for CD15. Furthermore, the patient had extranodal lesions and an increased level of soluble IL-2 receptor. These findings are unusual in CHL. Therefore, we diagnosed the patient with BCLu-DLBCL/CHL. She received adriamycin, bleomycin, vincristine, and dacarbazine therapy and exhibited partial response. Some cases without mediastinal disease, such as our case, have been reported; however, these cases are rare and further studies are required.

リンク情報
DOI
https://doi.org/10.1007/s00795-013-0038-8
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000324274200007&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s00795-013-0038-8
  • ISSN : 1860-1480
  • Web of Science ID : WOS:000324274200007

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