2015年3月30日
Cytokeratin-positive fibroblastic reticular cell tumor with follicular dendritic cell features : A case report and review of the literature
American Journal of Surgical Pathology
- 巻
- 39
- 号
- 4
- 開始ページ
- 573
- 終了ページ
- 580
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1097/PAS.0000000000000362
- 出版者・発行元
- Lippincott Williams and Wilkins
Fibroblastic reticular cell (FRC) neoplasms, which are one of the histiocyte tumor types, are very rare. Here we report a cytokeratin (CK)-positive FRC neoplasm having features of follicular dendritic cells in a 54-year-old woman with right axillary lymph node swelling. The resected lymph node showed multiple nodular aggregations simulating and replacing normal follicles. The tumor cells had a uniform, large and oval to polygonal shape, abundant cytoplasm, and various sizes of nuclei with central eosinophilic nucleoli and coarse nuclear chromatin. They were positive for CK AE1/AE3+CAM5.2, CK7, tenascin C, l-caldesomone, and CD21, weakly positive for S100, and negative for CD1a. Ultrastructurally, the tumor cells had long interdigitating microvillus-like cell processes and oval to elongated vesicular nuclei. In addition, the intercellular spaces contained accumulations of collagen, and some tumor cells had desmosomal-like junctions. These findings suggest that the present case is a CK-positive FRC tumor with follicular dendritic cell features.
- リンク情報
- ID情報
-
- DOI : 10.1097/PAS.0000000000000362
- ISSN : 1532-0979
- ISSN : 0147-5185
- PubMed ID : 25768257
- SCOPUS ID : 84925860909